Results 131 to 140 of about 2,058,652 (297)

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

Feature Importance Ranking Using Interval-Valued Methods and Aggregation Functions for Machine Learning Applications

Applied Sciences
Feature selection is one of the key stages in the process of creating machine learning models and conducting data analysis. This paper presents the results of research related to the implementation of a new algorithm for feature selection and ranking ...
Aleksander Wojtowicz, Wiesław Paja, Urszula Bentkowska   +2 more
doaj   +1 more source

Feature Signature Discovery for Autism Detection: An Automated Machine Learning Based Feature Ranking Framework. [PDF]

Comput Intell Neurosci, 2023
Jacob SG, Sulaiman MMBA, Bennet B.
europepmc   +1 more source

Feature ranking using IG on Inside 1 DARPA 2000 dataset.

, 2016
Feature ranking using IG on Inside 1 DARPA 2000 dataset.
Maheyzah Md Siraj (3366005), Huwaida Tagelsir Elshoush (3366011), Fatin Elhaj (3366008), Anazida Zainal (782459), Taqwa Ahmed Alhaj (3366002)   +4 more
core   +1 more source

Characterization of therapeutic antibodies targeting lymphatic and vascular resistance factor for the treatment of hypervascularized and highly metastatic cancers

Molecular Oncology, EarlyView.
LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David, Arthur Karaulic, Audrey Bennetot, Clémence Fournier, Quentin Odet, Arthur Gouraud, Isabelle Bourget, Cédric Gaggioli, Sandy Giuliano, Frédéric Luciano, Olivier Léger, Zaki Sellam, Gilles Pagès   +12 more
wiley   +1 more source

Attribute Relevance Score: A Novel Measure for Identifying Attribute Importance

Algorithms
This study introduces a novel measure for evaluating attribute relevance, specifically designed to accurately identify attributes that are intrinsically related to a phenomenon, while being sensitive to the asymmetry of those relationships and noise ...
Pablo Neirz, Hector Allende, Carolina Saavedra   +2 more
doaj   +1 more source

Reprogramming tumor cells with LCOR mRNA nanotherapy to enhance immunotherapy

Molecular Oncology, EarlyView.
LCOR (Ligand‐dependent corepressor) mRNA encapsulated in polymeric nanoparticles restores LCOR activity in tumor cells, constraining aggressive tumor cell states and increasing tumor immunogenicity. This reprogramming makes tumor cells more vulnerable to T‐cell attack and enhances their response to immune‐checkpoint immunotherapy.
Gabriel Serra‐Mir, Elena Haro‐Martínez, Sandra Blasco‐Benito, Chiara Cannatà, José Ángel Palomeque, Anna López‐Plana, Maria Sanz‐Flores, Marc Sabartés, Cristina Fornaguera, Toni Celià‐Terrassa   +9 more
wiley   +1 more source

Two phase feature-ranking for new soil dataset for Coxiella burnetii persistence and classification using machine learning models. [PDF]

Sci Rep, 2023
Ahmad F, Ghani Khan MU, Tahir A, Tipu MY, Rabbani M, Shabbir MZ.   +5 more
europepmc   +1 more source

Feature ranking using IG on Inside 2 DARPA 2000 dataset.

, 2016
Feature ranking using IG on Inside 2 DARPA 2000 dataset.
Maheyzah Md Siraj (3366005), Huwaida Tagelsir Elshoush (3366011), Fatin Elhaj (3366008), Anazida Zainal (782459), Taqwa Ahmed Alhaj (3366002)   +4 more
core   +1 more source

Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy

Molecular Oncology, EarlyView.
We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley   +1 more source