Results 131 to 140 of about 1,151,147 (311)

Phosphoinositides and inositol phosphates as molecular glues

FEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry, Alexander J. Cutright, Mong Na Claire Loi, Jessica Martin, Joseph W. Gilligan, Jakub N. Kubina, Michael J. Arambula, Susanna Tanada Palmu, Daniella Zhou, Raymond D. Blind   +9 more
wiley   +1 more source

Large-Margin Multiple Kernel Learning for Discriminative Features Selection and Representation Learning

, 2019
Hosseini B, Hammer B. Large-Margin Multiple Kernel Learning for Discriminative Features Selection and Representation Learning. Presented at the The 2019 International Joint Conference on Neural Networks (IJCNN), Budapest.Multiple kernel learning (MKL ...
Hammer, Barbara ; https://orcid.org/, Hosseini, Babak ; https://orcid.org/, Barbara Hammer, Babak Hosseini   +3 more
core   +1 more source

PARK(ing) time–How park deficiency affects the biological clock in a Drosophila model of Parkinson's disease

FEBS Letters, EarlyView.
Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara, Kinga Skoczek, Elzbieta Pyza, Milena Damulewicz   +3 more
wiley   +1 more source

Keratoconus Severity Classification Using Features Selection and Machine Learning Algorithms. [PDF]

Comput Math Methods Med, 2021
Aatila M, Lachgar M, Hamid H, Kartit A.
europepmc   +1 more source

Visual features selection [PDF]

, 2013
The state-of-the-art algorithms for large visual content recognition and content based similarity search today use the Bag of Features" (BoF) or Bag of Words (BoW) approach. The idea, borrowed from text retrieval, enables the use of inverted files. A very well known issue with the BoF approach is that the query images, as well as the stored data, are ...
Giuseppe A, Falchi F, Gennaro C
openaire   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Lung Radiomics Features Selection for COPD Stage Classification Based on Auto-Metric Graph Neural Network. [PDF]

Diagnostics (Basel), 2022
Yang Y, Wang S, Zeng N, Duan W, Chen Z, Liu Y, Li W, Guo Y, Chen H, Li X, Chen R, Kang Y.   +11 more
europepmc   +1 more source

α‐Synuclein aggregation landscape from phase separation to neurotoxic intermediates

FEBS Letters, EarlyView.
Alpha‐synuclein aggregation in Parkinson's disease involves a complex landscape of transient intermediates, including oligomers, fibrils and liquid–liquid phase separation (LLPS). A view is emerging in which LLPS maturation into solid‐like condensates may contribute to the formation of neurotoxic species.
Silvia Arino, Giuliana Fusco, Alfonso De Simone   +2 more
wiley   +1 more source

An optimized features selection approach based on Manta Ray Foraging Optimization (MRFO) method for parasite malaria classification. [PDF]

Front Public Health, 2022
Amin J, Sharif M, Mallah GA, Fernandes SL.   +3 more
europepmc   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source