Results 131 to 140 of about 1,515 (213)

Population pharmacokinetics and dose–response relationships of mitoxantrone in children with acute myeloid leukaemia

British Journal of Clinical Pharmacology, Volume 92, Issue 6, Page 1760-1770, June 2026.
Background Information on mitoxantrone pharmacokinetics in children is lacking and reduced dosing regimens applied to infants are supported by limited scientific rationale. The current study characterized mitoxantrone pharmacokinetics in a childhood acute myeloid leukaemia patient population and provides a data‐informed assessment of dosing.
Andrew M. Brandon, Hinke Huisman‐Siebinga, Shelby Barnett, Paul Wetherell, Pamela Kearns, Brenda Gibson, Nicholas Heaney, Owen Smith, André Baruchel, Arnaud Petit, Andrew Moore, Kayode Ogungbenro, Alwin D. R. Huitema, Gareth J. Veal   +13 more
wiley   +1 more source

Acalabrutinib Versus Venetoclax Plus Obinutuzumab in Treatment‐Naive Chronic Lymphocytic Leukemia: A Real‐World Propensity Score‐Matched Study

Cancer Medicine, Volume 15, Issue 6, June 2026.
In a real‐world matched cohort study of treatment‐naïve TP53 wild‐type CLL patients, venetoclax plus obinutuzumab demonstrated significantly longer time to next treatment and improved 4‐year overall survival compared to first‐line acalabrutinib. Despite higher rates of cytopenias and infections, the venetoclax‐based regimen showed superior efficacy ...
Po‐Wei Liao, Bor‐Sheng Ko, Yu‐Chen Su, Wei‐Ting Chao, Chieh‐Lin Jerry Teng   +4 more
wiley   +1 more source

Pancytopenia With Hypocellular Bone Marrow Revealing Extrahepatic Portal Venous Obstruction and Cavernous Transformation in a Child: A Case Report of a Diagnostic Challenge

Clinical Case Reports, Volume 14, Issue 6, June 2026.
ABSTRACT Extrahepatic portal venous obstruction (EHPVO) is a leading cause of prehepatic portal hypertension in children, particularly in developing countries. While upper gastrointestinal bleeding is the most common presentation, EHPVO may rarely manifest predominantly with hematological abnormalities due to hypersplenism, posing a diagnostic ...
Swekchha Adhikari, Aakash Pandit, Melisha Koirala, Biplav Lamichhane, Ram Khadka, Aashish Panta, Shuvra Rimal   +6 more
wiley   +1 more source

The effect of remote nursing (Telenursing) training on anxiety of mothers with children suffering from febrile convulsions [PDF]

Payesh
Objective(s): Convulsions caused by fever in children and parents not knowing about the nature of this disease cause severe anxiety and inappropriate performance in parents.
MohammadReza Jani, Ali ArabAhmadi, Ali Dashtgard, Mahla Salarfard, Rahman Panahi, Asma Nikkhah Beydokhti   +5 more
doaj  

Global disparities in the recognition, diagnosis, and management of seizures or epilepsy of autoimmune etiology

Epilepsia Open, Volume 11, Issue 3, Page 922-934, June 2026.
Abstract Objective Despite advancements in “autoimmune epilepsy,” more accurately referred to herein as seizures or epilepsy of autoimmune etiology, significant variability exists in its recognition, diagnosis, and management internationally. This study assessed clinicians' understanding, access to diagnostic tools, and treatment practices across ...
Emily Guarasci, Robyn Whitney, Adrian Budhram, Maryam Nabavi Nouri   +3 more
wiley   +1 more source

Incidence and outcomes of childhood status epilepticus in Kano, northern Nigeria

Epilepsia Open, Volume 11, Issue 3, Page 973-982, June 2026.
Abstract Objective Convulsive status epilepticus (CSE) is a major neurological emergency in childhood, but population‐based data from low‐ and middle‐income countries remain limited. We estimated the incidence, mortality, neurological outcomes, and predictors of adverse outcomes among children with CSE in Kano, northern Nigeria.
Umar A. Sabo, Halima Kabir, Aminu T. Abdullahi, Halima Adamu, Auwal S. Salihu, Abba M. Abdullahi, Aminu Wada, Zubairu Iliyasu, Jamilu Zakari, Safiya Gambo, Binta W. Jibir, Muktar H. Aliyu, Usman J. Wudil, Donna J. Ingles, Heather L. Prigmore, Bryan E. Shepherd, Angela R. Paolucci, Edwin Trevathan   +17 more
wiley   +1 more source

Anemia and Its Associated Factors Among Children Aged 6–23 Months in Nine Sub‐Saharan African Countries: A Multilevel Proportional Odds Model Using the Latest Demographic and Health Survey (DHS) Data

Health Science Reports, Volume 9, Issue 6, June 2026.
ABSTRACT Background Anemia remains highly prevalent among children aged 6–23 months in sub‐Saharan Africa. Previous estimates relied on outdated World Health Organization (WHO) hemoglobin cutoffs, which may have overestimated the burden. This study assessed anemia prevalence and associated factors using the updated 2024 WHO thresholds in nine sub ...
Temesgen Gebeyehu Wondmeneh
wiley   +1 more source

Significance and Usefulness of High‐Resolution 24‐h Electrocardiographic Parameters in Patients With Coronavirus Disease 2019 After Admission: A Prospective Cohort Study

Journal of Arrhythmia, Volume 42, Issue 3, June 2026.
In patients with coronavirus disease 2019 (COVID‐19) without an obvious cardiac disease, ambulatory electrocardiographic markers can be useful in assessing the risk of severe disease. Particularly, simultaneous positivity of late potential (LP) and T wave alternans (TWA) in patients with COVID‐19 was a poorer prognostic factor than LP or TWA alone ...
Motohiro Kimata, Kenichi Hashimoto, Naomi Harada, Yusuke Kawamura, Yoshifumi Kimizuka, Mayuko Kaneko, Nobuaki Kiriu, Yasumasa Sekine, Natsumi Iwabuchi, Tetsuro Kiyozumi, Susumu Matsukuma, Yuji Tanaka, Nobutaka Hirooka   +12 more
wiley   +1 more source

[intermittent Prophylaxis In Febrile Convulsions With Oral Diazepam].

, 2015
Intermittent prophylaxis with oral diazepam is presented as an optional treatment for febrile seizures. This proposition is justified by the severe side effects of the currently used chronic anticonvulsant drug therapy in febrile seizures (phenobarbital ...
Guerreiro, M M, Silva, E A, Scotoni, A E, Costa, M, Sabino, S H, Bellomo, M A   +5 more
core  

Clinical and Genetic Characterization of Inherited NPRL3 Splice Variants in Two Patients With Epilepsy

Molecular Genetics &Genomic Medicine, Volume 14, Issue 6, June 2026.
This study identifies two novel inherited NPRL3 splice variants in Chinese pediatric patients with focal epilepsy, revealing significant genetic heterogeneity, incomplete penetrance, and phenotypic variability that underscores the importance of tailored antiepileptic management.
Shouxing Wang, Jihua Wu, Conglei Song, Yuanzhi He, Zhongli Zhao, Bin Yang   +5 more
wiley   +1 more source