Results 151 to 160 of about 133,052 (292)

DNA methyltransferase inhibitors in hematological malignancies and solid tumors

open access: yesInternational Journal of Cancer, Volume 158, Issue 2, Page 433-461, 15 January 2026.
Abstract Epigenetic modifications such as DNA methylation play a fundamental role in oncogenesis and the progression of neoplasms neoplasias. DNA methyltransferase inhibitors (DNMTi) constitute a family of therapeutic agents that impede the methylation at the 5‐position on cytosine nucleotides, thereby modulating the epigenetic regulation of tumor ...
Valentin Wenger   +3 more
wiley   +1 more source

Characteristics of pediatric patients with febrile convulsions admitted to a tertiary care hospital in Riyadh, Saudi Arabia. [PDF]

open access: yesJ Family Community Med
Abuhaimed AA   +6 more
europepmc   +1 more source

K‐means clustering‐based analysis of quantitative ultrafast DCE‐MRI for predicting breast cancer response to neoadjuvant chemotherapy

open access: yesJournal of Applied Clinical Medical Physics, Volume 27, Issue 1, January 2026.
Abstract Purpose Achieving a pathologic complete response (pCR) following neoadjuvant chemotherapy (NAC) is strongly associated with improved survival. This study investigates whether bilateral asymmetry of quantitative perfusion parameters in normal parenchyma from ultrafast dynamic contrast‐enhanced MRI (DCE‐MRI), measured using k‐means clustering ...
Zhen Ren   +9 more
wiley   +1 more source

Fever Inspiration: Precision Engineering for Safe and Systemic Immunotherapy

open access: yesAdvanced Science, Volume 13, Issue 1, 5 January 2026.
This review examines engineered fever therapy (EFT) as a novel cancer treatment, harnessing fever's immunomodulatory effects to enhance systemic immune responses. It explores molecular mechanisms, advances in nanotechnology‐driven thermal immunotherapy, and a bioengineered framework for precise, safe fever induction. The paper evaluates EFT's potential
Yang Li   +5 more
wiley   +1 more source

Investigation into the Pancreatic Pathogenesis of SFTSV across Multiple Levels

open access: yesAdvanced Science, Volume 13, Issue 1, 5 January 2026.
A retrospective analysis revealed that 17.6% of severe fever with thrombocytopenia syndrome (SFTS) patients met the diagnostic criteria for clinically confirmed pancreatitis. Using human pancreatic organoids and murine models demonstrated that SFTSV exhibits a specific pancreatic tropism, leading to cell death and initiating a strong inflammatory ...
Xiaohan Liu   +10 more
wiley   +1 more source

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