Results 61 to 70 of about 23,044 (252)
Annals of Neurology, EarlyView.Objective Pathogenic variants in GNAO1 cause a spectrum of epilepsy, movement disorders, and developmental impairment. Clinical heterogeneity complicates prognosis and therapeutic development. We present the first longitudinal natural history study of GNAO1‐related disorders (GNAO1‐RD) to delineate phenotypic trajectories. Methods Sixty‐six individuals
Jana Domínguez‐Carral +52 more
wiley +1 more source
From Interferon Signature to the Clinical Landscape: Type I Interferonopathies
Arthritis &Rheumatology, Accepted Article.Background Type I interferonopathies are heterogeneous diseases driven by dysregulated IFN‐I signaling. Diagnosis is challenging due to clinical/molecular variability and the need for IFN‐I quantification. Objective To characterize the clinical, immunological, genetic, molecular profiles of patients with suspected enhanced IFN‐I signaling, and assess ...
Ismail Yaz +13 more
wiley +1 more source
British Journal of Clinical Pharmacology, EarlyView.Aim This study aimed to compare how Norwegian healthcare professionals (HCPs) and consumers reported the same adverse event (AE) following immunization with vaccines against COVID‐19 during the COVID‐19 pandemic. Specifically, we aimed to compare the extent to which HCPs and consumers reported information relevant for assessing the causal relationship ...
Tommy Emil Dzus +4 more
wiley +1 more source
“The Most Difficult Conversations We Have”: Resident Experiences With Pediatric Neuroprognostication
Annals of the Child Neurology Society, EarlyView.ABSTRACT Objective Pediatric neuroprognostication is often complicated by uncertainty and embedded in high‐stakes medical decisions. For child neurology residents, participation in neuroprognostication can represent key learning experiences but also comes with emotional and ethical challenges, which poses a risk of moral distress.
Grant L. Lin +7 more
wiley +1 more source
Intensive Induction in AML in the Era of Venetoclax: A Standing Count for “7 + 3”?
American Journal of Hematology, EarlyView.
Sudhir Tauro, Ayalew Tefferi
wiley +1 more source
Clinical Pharmacology &Therapeutics, EarlyView.Demonstrating pharmacological effects in early‐phase oncology clinical trials remains challenging, largely due to the lack of robust pharmacodynamic markers. Lipopolysaccharide (LPS) is used as an immune challenge agent in healthy participants to study drugs for autoimmune conditions.
Igor Radanović +11 more
wiley +1 more source
EcoEnergy, EarlyView.This review systematically examines how different transition metal compounds—such as binary and multinary metal oxides, halides, sulfides, and salts—exhibit thermochromism based on the d‐electron configurations of their transition metal cations. It focuses on three main mechanisms of thermochromism: phase transition, charge transfer, and bandgap change.
Jie Wang +5 more
wiley +1 more source
Epileptic Disorders, EarlyView.Abstract Objective Febrile seizures (FS) are the most common seizures in childhood, yet identifying children at risk of developing epilepsy after the first FS remains challenging. We aimed to evaluate the prognostic potential of machine learning (ML) algorithms applied to post‐febrile seizure electroencephalography (EEG) recordings.
Boran Şekeroğlu +7 more
wiley +1 more source
Periodontology 2000, EarlyView., 2023 Abstract This narrative review celebrates Europe's contribution to the current knowledge on systemically administered antimicrobials in periodontal treatment. Periodontitis is the most frequent chronic noncommunicable human disease. It is caused by dysbiotic bacterial biofilms and is commonly treated with subgingival instrumentation.
David Herrera +4 more
wiley +1 more source