Results 71 to 80 of about 445,926 (335)

Multitasking Smart Intestinal Capsule Robot: A Cutting‐Edge Platform for Sampling, Diagnosis, and Therapy

Advanced Robotics Research, EarlyView.
Gut microbiota and biomarkers are linked to diseases like neurological disorders and metabolic syndromes. Ingestible capsule robots enable minimally invasive gut health assessment. This article proposes a promising direction for the advancement of capsule robots, integrating in situ sampling, real‐time diagnostics, and personalized therapy.
Xizong Chen, Libing Huang, Lei Ren, Miao Wang   +3 more
wiley   +1 more source

Human metabolism and elimination of the anthocyanin, cyanidin-3-glucoside: a 13C-tracer study [PDF]

, 2013
BACKGROUND: Evidence suggests that the consumption of anthocyanin-rich foods beneficially affects cardiovascular health; however, the absorption, distribution, metabolism, and elimination (ADME) of anthocyanin-rich foods are relatively unknown. OBJECTIVE:
Aedín Cassidy, Cassidy, Charles Czank, Colin D Kay, Das, Das, de Pascual-Teresa, Del Bò, Del Rio, Douglas J Morrison, Felgines, Felgines, Felgines, Garcia-Alonso, González-Barrio, Haycock, Hooper, Ichiyanagi, Kay, Kay, Kay, Manach, Mazza, McCullough, Milbury, Mink, Miyazawa, Morrison, Morrison, Morrison, Mullen, Neveu, Nigel P Botting, Nurmi, Paul A Kroon, Qingzhi Zhang, Shreeve, Slater, Tom Preston, Tsuda, Ueno, Vitaglione, Wallace, Walle, Williamson, Williamson, Woodward, Wu, Zhang, Zhang, Zhang   +50 more
core   +1 more source

Dual‐Functional Ingestible Passive Capsules for High‐Throughput Intestinal Sampling with Sealed Containment and Targeted Drug Delivery

Advanced Robotics Research, EarlyView.
To address challenges in high‐throughput intestinal sampling with sealed containment and target drug delivery, we developed a dual‐functional ingestible passive capsule with a dual‐triggered control system based on pH‐response and mechanical actuation.
Libing Huang, Houyu Ling, Xizong Chen, Yufei Duan, Yu Liu, Shuntian Cai, Yandan Ren, Wenlong Li, Lei Ren, Miao Wang   +9 more
wiley   +1 more source

Sources of error in the isotopic cholesterol balance method in African green monkeys consuming a cholesterol-free diet

Journal of Lipid Research, 1980
Six African green monkeys were labeled intravenously with [1,2-(3)H]cholesterol while consuming a cholesterol-free liquid formula diet. The plasma cholesterol specific activity was compared with the specific activity of the biliary cholesterol and bile ...
G R Henderson, R W St Clair
doaj   +1 more source

Midbrain PAG Astrocytes Modulate Mouse Defensive and Panic‐Like Behaviors

Advanced Science, EarlyView.
Astrocytes in the midbrain periaqueductal gray (PAG) dynamically encode threat intensity and shape defensive action selection in mice. Real‐time Ca2+ imaging reveals robust astrocytic activation during predator odor and CO2 exposure. Aberrant astrocytic Ca2+ overactivation disrupts goal‐directed escape, biases behavior toward freezing, and induces ...
Ellane Barcelon, Kyungchul Noh, Minkyu Hwang, Yoon‐Jung Kim, Unjin Lee, Yeon Joo Ryu, Je‐Kyung Ryu, Sang Beom Jun, Se‐Young Choi, Woo‐Hyun Cho, Sung Joong Lee   +10 more
wiley   +1 more source

Hepatic accumulation of intestinal cholesterol is decreased and fecal cholesterol excretion is increased in mice fed a high-fat diet supplemented with milk phospholipids

Nutrition & Metabolism, 2010
Background Milk phospholipids (PLs) reduce liver lipid levels when given as a dietary supplement to mice fed a high-fat diet. We have speculated that this might be due to reduced intestinal cholesterol uptake.
Weir Jacquelyn M, Tandy Sally, Chung Rosanna WS, Wat Elaine, Kamili Alvin, Meikle Peter J, Cohn Jeffrey S   +6 more
doaj   +1 more source

Urinary and Fecal Excretion of Orally Administered Mg28.

Experimental Biology and Medicine, 1958
SummaryA tracer dose of Mg28 (10 to 25 μc contained in 3 to 10 meq of magnesium) was administered orally to 26 subjects, and serial specimens of blood, urine and feces were assayed for radioactivity. Urinary excretion within 72 hours accounted for less than 10% of total dose of Mg28; the maximal excretion (6.3%) occurred during the first 24-hour period.
J K, AIKAWA, E L, RHOADES, G S, GORDON
openaire   +2 more sources

Gut Microbiota‐Derived Anandamide Mediates the Therapeutic Effects of Urolithin A on Alcohol‐Induced Cognitive and Social Dysfunction via CB1R‐DRD2‐RAP1 Signaling Axis

Advanced Science, EarlyView.
This study reveals that Urolithin A (UA) counteracts alcohol‐induced cognitive and social dysfunction (AICSD) via a gut microbiome‐dependent mechanism. UA‐enriched Bacteroids sartorii and Parabacteroids distasonis elevate anandamide (AEA), which activates the CB1R‐DRD2‐Rap1 signaling cascade to drive synaptic repair and reduce neuroinflammation ...
Hongbo Zhang, Zibin Li, Yao Xiao, Ji Bian, Caian He, Chao Liu, Lan Gong, Lin Han, Zhigang Liu, Min Wang   +9 more
wiley   +1 more source

Liver X receptor-mediated activation of reverse cholesterol transport from macrophages to feces in vivo requires ABCG5/G8

Journal of Lipid Research, 2008
Liver X receptor (LXR) agonists increase both total fecal sterol excretion and macrophage-specific reverse cholesterol transport (RCT) in vivo. In this study, we assessed the effects of ABCG5/G8 deficiency as well as those of LXR agonist-induction of RCT
Laura Calpe-Berdiel, Noemí Rotllan, Catherine Fiévet, Rosa Roig, Francisco Blanco-Vaca, Joan Carles Escolà-Gil   +5 more
doaj   +1 more source

Probiotic E. coli treatment mediates antimicrobial human β-defensin synthesis and fecal excretion in humans

Mucosal Immunology, 2009
Inducible epithelial human β-defensins (hBD) play an important role in intestinal barrier function. In vitro studies showed that clinically effective probiotics induce antimicrobial hBD-2. Here, we aimed to assess the in vivo effect in healthy volunteers
M. Moendel, B. Schroeder, K. Zimmermann, H. Huber, S. Nuding, J. Beisner, K. Fellermann, Eduard F. Stange, J. Wehkamp, J. Wehkamp   +9 more
semanticscholar   +1 more source