Results 51 to 60 of about 29,965 (259)

Urinary and Fecal Excretion of Dimethylamine in Rats

Food Hygiene and Safety Science (Shokuhin Eiseigaku Zasshi), 1982
A study was undertaken to determine the intake and excretion balance of dimethylamine (DMA) in rats prior to work on the metabolism of DMA. Rats were maintained in a metabolic cage individually, and the intake and urinary and fecal excretions of DMA were determined.
Hajimu ISHIWATA, Ryoichi IWATA, Akio TANIMURA   +2 more
openaire   +3 more sources

Bifidobacterium Pseudolongum‐Derived Inosine Mitigates Polystyrene Nanoplastics‐Induced Hepatic Injury by Inhibiting the Polarization of M1 Macrophages

Advanced Science, EarlyView.
Probiotic B.p colonization elevated gut‐derived inosine level in the liver, while elevated inosine activated A2AR and subsequently blocked NPs‐induced polarization of M1 macrophages by repressing the miR155/SOCS1/NF‐κB pathway. This reduced the release of inflammatory cytokines and thereby, mitigated NPs‐induced hepatic injury.
Kaikai Zhang, Yuchuan Chen, Jiayuan Wan, Jianzheng Yang, Lijian Chen, Qingyuan Li, Anding Zhou, Nian Zhou, Jiuyang Ding, Qi Wang, Jian Sun   +10 more
wiley   +1 more source

Acute sterol o-acyltransferase 2 (SOAT2) knockdown rapidly mobilizes hepatic cholesterol for fecal excretion.

PLoS ONE, 2014
The primary risk factor for atherosclerotic cardiovascular disease is LDL cholesterol, which can be reduced by increasing cholesterol excretion from the body.
Stephanie M Marshall, Anthony D Gromovsky, Kathryn L Kelley, Matthew A Davis, Martha D Wilson, Richard G Lee, Rosanne M Crooke, Mark J Graham, Lawrence L Rudel, J Mark Brown, Ryan E Temel   +10 more
doaj   +1 more source

Lactation is Associated with Accelerated Postpartum Pelvic Floor Muscle Recovery in a Pregnant Simulated Birth Injury Model

Advanced Science, EarlyView.
ABSTRACT Healthy pelvic floor muscles (PFMs) are essential for proper pelvic floor function. The biggest risk factor for PFM dysfunction is injury sustained during vaginal childbirth, yet the factors that facilitate or impair PFM recovery from birth injury remain unknown.
Bianca L. Peña, Khushi M. Diwakar, Hillary K. Tran, Selena Cao, Celeste E. Lintz, Laila N. Hayes, Marianna Alperin, Karen L. Christman   +7 more
wiley   +1 more source

Urinary and Fecal Coproporphyrin Excretion in Rats. III. Excretion of Injected Coproporphyrin.

Experimental Biology and Medicine, 1953
Summary and Conclusions1. Studies have been made of the urinary and fecal excretion of coproporphyrins I and III administered intravenously to rats. In the normal animal, no increase in urinary excretion occurred; approximately one-half of the injected material was excreted in the feces. 2.
F W, HOFFBAUER, C J, WATSON, S, SCHWARTZ
openaire   +2 more sources

SuFEx‐Enabled Reprogramming of Flavonoids for Selective α‐Glucosidase Covalent Inhibition

Advanced Science, EarlyView.
Selective inhibition of intestinal α‐glucosidase remains limited by poor enzyme specificity and off‐target metabolic effects. Here, SuFEx click chemistry is used to reprogram natural flavonoids into covalent inhibitors with enhanced α‐glucosidase selectivity and controlled reactivity. This strategy enables effective regulation of carbohydrate digestion
Fengyu Guo, Liwei Zhang, Minlong Wang, Yanjin Du, Tianyu Zhang, Hao Chen, Jiazeng Sun, Yang Yu, Zude He, Jie An, Xiaoxu Zhang, Weilin Lin, Fazheng Ren, Pengjie Wang, Ping Liu   +14 more
wiley   +1 more source

Comparative Study on Excretive Characterization of Main Components in Herb Pair Notoginseng-Safflower and Single Herbs by LC–MS/MS

Pharmaceutics, 2018
The herbal medicine combination of notoginseng-safflower has been commonly used clinically for the prevention and treatment of cardiovascular diseases.
Ying-Yuan Lu, Jin-Yang Song, Yan Li, Yu-Qing Meng, Ming-Bo Zhao, Yong Jiang, Peng-Fei Tu, Xiao-Yu Guo   +7 more
doaj   +1 more source

AI‐Designed Cyclic Peptides Enable Controllable Modulation of the CD28 Immune Checkpoint

Advanced Science, EarlyView.
AI‐designed cyclic peptides enable controllable modulation of the CD28 immune checkpoint through reversible disruption of CD28‐CD80/CD86 interactions. The lead peptide, CIP‐3, suppresses T‐cell activation without intrinsic agonist activity, demonstrates dose‐dependent efficacy in a murine colitis model, and attenuates inflammatory cytokine production ...
Katarzyna Kuncewicz, Saurabh Upadhyay, Renjie Zhu, Hongliang Duan, Moustafa T. Gabr   +4 more
wiley   +1 more source

Liver X receptor-mediated activation of reverse cholesterol transport from macrophages to feces in vivo requires ABCG5/G8

Journal of Lipid Research, 2008
Liver X receptor (LXR) agonists increase both total fecal sterol excretion and macrophage-specific reverse cholesterol transport (RCT) in vivo. In this study, we assessed the effects of ABCG5/G8 deficiency as well as those of LXR agonist-induction of RCT
Laura Calpe-Berdiel, Noemí Rotllan, Catherine Fiévet, Rosa Roig, Francisco Blanco-Vaca, Joan Carles Escolà-Gil   +5 more
doaj   +1 more source

Increasing Effect of Nori on the Fecal Excretion of Dioxin by Rats

Bioscience, Biotechnology, and Biochemistry, 2002
The effects of nori (Porphyra yezoensis), a kind of red alga, on the gastrointestinal absorption and reabsorption of 17 types of dioxin were investigated in male Wistar rats. The rats were fed with 4 g of the control diet or 4 g of the nori diet containing a standard dioxin solution (233 ngTEQ/kg of body weight) for five consecutive days.
MORITA, Kunimasa, TOBIISHI, Kazuhiro
openaire   +2 more sources