Results 1 to 10 of about 309,624 (120)

Pharmacokinetics, Tissue Distribution and Excretion of Demethyleneberberine, a Metabolite of Berberine, in Rats and Mice

Molecules, 2023
Demethyleneberberine is an active component extracted from the Chinese herbal drug Cortex Phellodendri. It is also a metabolite of berberine in animals and humans.
Jingqi Li, Qi Zhang, Yutong Chen, Chengyu Lu, Yongbin Tong   +4 more
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Pharmacokinetics, bioavailability, and excretion of ponazuril in piglets

Frontiers in Veterinary Science, 2022
Ponazuril is a triazine anticoccidial drug which is the main metabolite of toltrazuril in animals, it has excellent activity against many protozoa, including Cystoisospora suis, and has broad application prospects in the control of swine coccidiosis.
Wenxiang Wang, Yuqiao Ma, Yunxiao Zhang, Jingjing Nie, Daxing Hu, Weicong Yang, Yue Shen, Xinglong Cui, Huanzhong Ding, Li Li, Xianhui Huang   +10 more
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Pharmacokinetics, absorption, distribution, metabolism and excretion of the MEK inhibitor zapnometinib in rats

Frontiers in Pharmacology, 2022
Zapnometinib is a MEK inhibitor currently under clinical development for the treatment of COVID-19 and influenza. Zapnometinib has both antiviral and immunomodulatory effects. Information concerning the absorption, distribution, metabolism, and excretion
Yvonne Füll, Yvonne Füll, Christian Wallasch, Ashley Hilton, Oliver Planz, Oliver Planz   +5 more
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Regulation Mechanisms of Expression and Function of Organic Cation Transporter 1

Frontiers in Pharmacology, 2021
The organic cation transporter 1 (OCT1) belongs together with OCT2 and OCT3 to the solute carrier family 22 (SLC22). OCTs are involved in the movement of organic cations through the plasma membrane.
Giuliano Ciarimboli
doaj   +1 more source

PHARMACOKINETIC PROPERTIES OF A NEW KAPPA-OPIOID ANALGESIC RU-1205 COMPOUND AT A SINGLE PERORAL ADMINISTRATION

Фармация и фармакология (Пятигорск), 2021
The aim of the study is the investigation of the pharmacokinetic properties of the RU-1205 compound, with previously identified kappa-agonistic and analgesic effects, at a single oral administration, as well as comparison of the relationship between its ...
A. A. Spasov, L. A. Smirnova, O. Yu. Grechko, N. V. Eliseeva, Yu. V. Lifanova, A. I. Rashchenko, O. N. Zhukovskaya, A. S. Morkovnik, V. A. Anisimova   +8 more
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Pharmacokinetics, Tissue Distribution and Excretion of Paeonol and Its Major Metabolites in Rats Provide a Further Insight Into Paeonol Effectiveness

Frontiers in Pharmacology, 2020
Paeonol is a major bioactive ingredient in Moutan Cortex (the root barks of Paeonia suffruticosa Andrews) and exhibited a wide range of bioactivities such as anti-inflammation, anti-oxidation, hypoglycemic effect, analgesic, and others.
Xintong Hu, Xintong Hu, Liqin Ding, Shijie Cao, Lina Cheng, Lina Cheng, Kun Wang, Kun Wang, Chenxi Guang, Chenxi Guang, Wei Li, Wei Li, Kazuo Koike, Feng Qiu, Feng Qiu   +14 more
doaj   +1 more source

Pharmacokinetics and Excretion Study of Lycium barbarum Polysaccharides in Rats by FITC-Fluorescence Labeling

Foods, 2021
A high-performance gel permeation chromatography fluorescence detection (HPGPC-FD) method combined with fluorescein isothiocyanate (FITC) labeling was established for the microanalysis of L. barbarum polysaccharides (LBP).
Hui Xia, Chao Yang, Beijia Zhou, Huali Tang, Ligang Yang, Wang Liao, Guiju Sun   +6 more
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Impact of Particle Size on Toxicity, Tissue Distribution and Excretion Kinetics of Subchronic Intratracheal Instilled Silver Nanoparticles in Mice

Toxics, 2022
The unique physicochemical properties of silver nanoparticles (AgNPs) make them useful in a wide range of sectors, increasing their propensity for human exposure, as well as the need for thorough toxicological assessment.
Fernanda Rosário, Jan Creylman, Geert Verheyen, Sabine Van Miert, Conceição Santos, Peter Hoet, Helena Oliveira   +6 more
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Absorption, metabolism, and excretion of [14C]dersimelagon, an investigational oral selective melanocortin 1 receptor agonist, in preclinical species and healthy volunteers

Pharmacology Research & Perspectives, 2023
Dersimelagon (formerly MT‐7117) is a novel, orally administered nonpeptide small molecule selective agonist for melanocortin 1 receptor currently being investigated for the treatment of erythropoietic protoporphyria, X‐linked protoporphyria, and diffuse ...
Minoru Tsuda, Kei Ogawa, Tadashi Endou, Takahiro Goto, Yuko Ogasawara, Akihito Ogasawara   +5 more
doaj   +1 more source

Developmental Pharmacokinetics of Antibiotics Used in Neonatal ICU: Focus on Preterm Infants

Biomedicines, 2023
Neonatal Infections are among the most common reasons for admission to the intensive care unit. Neonatal sepsis (NS) significantly contributes to mortality rates.
Olga I. Butranova, Elena A. Ushkalova, Sergey K. Zyryanov, Mikhail S. Chenkurov   +3 more
doaj   +1 more source