Results 11 to 20 of about 309,773 (263)

Experimental Infection of Captive Red Foxes (Vulpes vulpes) with Mycobacterium bovis

open access: yesMicroorganisms, 2022
In Europe, animal tuberculosis (TB) due to Mycobacterium bovis involves multi-host communities that include cattle and wildlife species, such as wild boar (Sus scrofa), badgers (Meles meles) and red deer (Cervus elaphus).
Céline Richomme   +15 more
doaj   +1 more source

The Widely Conserved ebo Cluster Is Involved in Precursor Transport to the Periplasm during Scytonemin Synthesis in Nostoc punctiforme

open access: yesmBio, 2018
Scytonemin is a dimeric indole-phenol sunscreen synthesized by some cyanobacteria under conditions of exposure to UVA radiation. While its biosynthetic pathway has been elucidated only partially, comparative genomics reveals that the scytonemin operon ...
Kevin Klicki   +5 more
doaj   +1 more source

Pre-Clinical Pharmacokinetic Characterization, Tissue Distribution, and Excretion Studies of Novel Edaravone Oral Prodrug, TEJ-1704

open access: yesPharmaceutics, 2021
Edaravone (3-methyl-1-phenyl-2-pyrazolin-5-one) is a free radical scavenger approved for the treatment of amyotrophic lateral sclerosis, a fatal neuromuscular disease. Edaravone is administered as an intravenous infusion over 60 min for several treatment
Dong Wook Kang   +9 more
doaj   +1 more source

Intracellular Localization during Blood–Brain Barrier Crossing Influences Extracellular Release and Uptake of Fluorescent Nanoprobes

open access: yesNanomaterials, 2023
To improve the efficacy of nanoparticles (NPs) and boost their theragnostic potential for brain diseases, it is key to understand the mechanisms controlling blood–brain barrier (BBB) crossing.
Ornella Muscetti   +4 more
doaj   +1 more source

Efficacy, Pharmacokinetics, Biodistribution and Excretion of a Novel Acylated Long-Acting Insulin Analogue INS061 in Rats

open access: yesDrug Design, Development and Therapy, 2021
Kai Pan,1,2 Xiaolei Shi,2 Kai Liu,3 Ju Wang,2 Yijun Chen1 1State Key Laboratory of Natural Medicines and Laboratory of Chemical Biology, China Pharmaceutical University, Nanjing, Jiangsu Province, 211198, People’s Republic of China; 2Jiangsu Hengrui ...
Pan K, Shi X, Liu K, Wang J, Chen Y
doaj  

Sodium excretion and associated factors in urine samples of African descendants in Alcântara, Brazil: a population based study

open access: yesRenal Failure, 2018
In most countries, salt intake has been excessive and constitutes one of the main risk factors for disease development, especially hypertension. Factors such as age, gender, sedentary lifestyle, smoking, African descent, obesity, dietary habits and ...
Elisângela Milhomem dos Santos   +7 more
doaj   +1 more source

Excretion of Vancomycin-Resistant Enterococci by Wild Mammals

open access: yesEmerging Infectious Diseases, 2002
A survey of fecal samples found enterococcal excretion in 82% of 388 bank voles (Clethrionomys glareolus), 92% of 131 woodmice (Apodemus sylvaticus), and 75% of 165 badgers (Meles meles). Vancomycin-resistant enterococci, all Enterococcus faecium of vanA
David J. P. Mallon   +6 more
doaj   +1 more source

A novel member of the trehalose transporter family functions as an H+-dependent trehalose transporter in the reabsorption of trehalose in Malpighian tubules.

open access: yesFrontiers in Physiology, 2012
In insects, Malpighian tubules are functionally analogous to mammalian kidneys in that they not only are essential to excrete waste molecules into the lumen but also are responsible for the reabsorption of indispensable molecules, such as sugars, from ...
Shingo eKikuta   +5 more
doaj   +1 more source

Pharmacokinetics, Bioavailability, Excretion and Metabolism Studies of Akebia Saponin D in Rats: Causes of the Ultra-Low Oral Bioavailability and Metabolic Pathway

open access: yesFrontiers in Pharmacology, 2021
Background: Akebia saponin D (ASD) has a variety of biological activities and great medicinal potential, but its oral bioavailability is so low as to limit its development.
Pengfei Li   +10 more
doaj   +1 more source

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