Results 21 to 30 of about 309,773 (263)

Pharmacokinetics, Mass Balance, Excretion, and Tissue Distribution of Plasmalogen Precursor PPI-1011

Frontiers in Cell and Developmental Biology, 2022
PPI-1011 is a synthetic plasmalogen precursor in development as a treatment for multiple plasmalogen-deficiency disorders. Previous work has demonstrated the ability of PPI-1011 to augment plasmalogens and its effects in vitro and in vivo, however, the ...
Tara Smith, Kaeli J. Knudsen, Shawn A. Ritchie   +2 more
doaj   +1 more source

Exploring the potential hazard of Mycobacterium avium subspecies paratuberculosis as a cause for Crohn's disease [PDF]

Veterinary World, 2017
Background: Mycobacterium avium subspecies paratuberculosis (MAP) is the causative agent of Johne's disease (JD), or paratuberculosis in ruminants has been suspected to be implicated in the pathogenesis of Crohn's disease (CD) in humans with chronic ...
Sukumar Bharathy, Lakshmanasami Gunaseelan, Kannan Porteen   +2 more
doaj   +1 more source

Extracellular Production of Glutathione by Recombinant Escherichia coli K-12

Microbiology Research, 2023
The goal of this study was to produce a sufficient amount of glutathione in the fermentation medium without the addition of cysteine. This would simplify and reduce the cost of its purification.
Hideyuki Suzuki, Kazuki Nishida, Tatsuya Nakamura   +2 more
doaj   +1 more source

Distribution and Excretion of Arsenic Metabolites after Oral Administration of Seafood-Related Organoarsenicals in Rats

Metals, 2016
Less information is available on the metabolism of organic arsenicals compared to inorganic arsenic in mammals. In the present study, we investigated tissue distribution, metabolism and excretion in rats of organoarsenicals, dimethylarsinic acid (DMAV ...
Yayoi Kobayashi, Seishiro Hirano
doaj   +1 more source

Network pharmacology and molecular docking investigation of Curcuma xanthorrhiza Roxb. rhizome with the mechanisms underlying as the potential drug of eczema treatment

Journal of Advanced Pharmaceutical Technology & Research
A chronic inflammatory dermatosis, eczema, affects more than 12% of the pediatric population and 7.2% of adults. Clinically, it presents with erythematous, scaly, and intensely pruritic lesions.
Yusuf Alif Pratama, Honey Dzikri Marhaeny, Sulistyanengci Winarto, Igansius Agyo Palmado, Muhammad Hermawan Widyananda, Mahardian Rahmadi, Muhammad Taher, Ahmed Abdallah Hasan, Burkhard Kleuser, Junaidi Khotib   +9 more
doaj   +1 more source

Tolerance and Excretion of the Mycotoxins Aflatoxin B1, Zearalenone, Deoxynivalenol, and Ochratoxin A by Alphitobius diaperinus and Hermetia illucens from Contaminated Substrates

Toxins, 2018
This study aimed to investigate the potential accumulation of mycotoxins in the lesser mealworm (Alphitobius diaperinus, LMW) and black soldier fly (Hermetia illucens, BSF) larvae.
Louise Camenzuli, Ruud Van Dam, Theo de Rijk, Rob Andriessen, Jeroen Van Schelt, H. J. (Ine) Van der Fels-Klerx   +5 more
doaj   +1 more source

Investigating Stoichiometric Controls of Nutrient Recycling in Rivers Using the Threespine Stickleback (Gasterosteus aculeatus)

Ecology and Evolution
In freshwater ecosystems, fish play a critical role in regulating the standing stock and turnover rates of biologically important elements such as nitrogen (N) and phosphorus (P).
Sarah R. Rozanski, Emily M. May, Rana W. El‐Sabaawi   +2 more
doaj   +1 more source

Increased Risk of Sarcomas in Children With Congenital Anomalies: Findings From the Genetic Overlap Between Anomalies and Cancer in Kids (GOBACK) Registry Linkage Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Pediatric sarcomas are a heterogeneous group of tumors that contribute disproportionately to cancer mortality in children. Although congenital anomalies are among the strongest known risk factors for childhood cancer, the risk of specific sarcoma subtypes among affected individuals has not yet been thoroughly evaluated. Procedure We
Russ Wolters, Ji Yun Tark, Tiffany M. Chambers, Tania A. Desrosiers, Michael E. Scheurer, Charles Shumate, Wendy N. Nembhard, Mahsa M. Yazdy, Eirini Nestoridi, Amanda E. Janitz, Jean Paul Tanner, Russell S. Kirby, Jason L. Salemi, Yao Yu, Chad D. Huff, Sharon E. Plon, Philip J. Lupo, Jeremy M. Schraw   +17 more
wiley   +1 more source

Association Between Low-Dose Aspirin and Uric Acid in the Elderly: An Observational Retrospective Cross-Sectional Study

International Journal of General Medicine, 2021
Jia-Run Li, Yan Fan, Mei-Lin Liu Department of Geriatrics, Peking University First Hospital, Beijing, 100034, People’s Republic of ChinaCorrespondence: Mei-Lin Liu Tel +86 13910251863Email liumeilin@hotmail.comPurpose: Uric acid is an independent ...
Li JR, Fan Y, Liu ML
doaj  

Therapeutic Apheresis for Intravenous Methylprednisolone‐Refractory Neuromyelitis Optica Spectrum Disorder: Clinical and Radiological Outcomes in a Single‐Center Case Series

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Neuromyelitis optica spectrum disorder (NMOSD) is a relapsing autoimmune disease of the central nervous system. High‐dose intravenous methylprednisolone (IVMP) is the standard first‐line therapy for acute attacks, although some patients remain refractory.
Wataru Horiguchi, Daisuke Katagiri, Takeyuki Watadani, Shunichi Matsuda, Hiroshi Kaneko, Noritoshi Arai   +5 more
wiley   +1 more source