Results 201 to 210 of about 182,390 (269)

Child exposure to animal feces and zoonotic pathogens in northwest Ecuador: A mixed-methods study. [PDF]

PLoS Negl Trop Dis
Albán V, Ballard AM, Jesser KJ, Lee GO, Eisenberg JNS, Garzon-Chavez D, Trueba G, Caruso BA, Levy K.   +8 more
europepmc   +1 more source

Development of a sustainable water treatment process using biochar as substrate for filtration and coliform removal

The Canadian Journal of Chemical Engineering, EarlyView.
Preparation, modification, and characterization of biochar from woodchips and its application in stream water filtration, evaluated through physicochemical and microbiological analyses. Abstract Global microbial water contamination affects 1.8 billion people, necessitating efficient and sustainable treatment methods.
Tariq Khalil, Muhammad Ishtiaq Ali, Rameesha Abid, Anab Mujtaba, Rabia Asghar, Asif Jamal, Yusuf Tutar, Ahsan Habib, Fakhraddin Yusubov   +8 more
wiley   +1 more source

Hepatitis B Virus in Gabonese Non-Human Primate: Potential Zoonotic Circulation and Long-Term Strain Persistence. [PDF]

Pathogens
Koumba Mavoungou DS, Boundenga L, Lekana-Douki SE, Pendy NML, Moukouama SEK, Kombila LB, Falque G, Mangombi JB, Mouinga-Ondeme A, Dedkov V, Dacheux L, Aghokeng AF, N'dilimabaka N.   +12 more
europepmc   +1 more source

Payload‐Based Clinical Pharmacology Review of Approved Antibody–Drug Conjugates: Commonalities and Considerations for Streamlined Development

Clinical Pharmacology &Therapeutics, EarlyView.
Antibody–drug conjugates (ADCs) combine the specificity of an antibody with the potency of a cytotoxic drug. Thirteen ADCs, utilizing seven unique cytotoxic payloads and targeting 11 distinct antigens, are currently approved by the US Food and Drug Administration as of June 2025, representing a rapidly growing and highly promising class of anticancer ...
Sijie Lu, Qingqing Xiao, Lixuan Qian, Siyuan Sun, Zhu Zhou, Michael Z. Liao, Chunze Li   +6 more
wiley   +1 more source

Winter Grazing in Vineyards Suppresses Pathogens and Promotes Grapevine Health. [PDF]

Plants (Basel)
Cui S, Zhou L, Li D, Song Y, Wu H, Huang X, Jin D, Xiao H, Liu Y.   +8 more
europepmc   +1 more source

Ruxolitinib Pharmacokinetics and Exposure–Toxicity Relationship in Hematologic Malignancies and Immune‐Mediated Diseases: A Prospective Observational Study

Clinical Pharmacology &Therapeutics, EarlyView.
Ruxolitinib pharmacokinetics (PK) has been characterized in clinical trials but remains poorly documented in real‐world practice. This project aimed to investigate ruxolitinib PK in routine clinical practice, identify factors driving its variability, and explore exposure–response relationships to assess the potential role of therapeutic drug monitoring.
Jérémie Tachet, Sara C. Meyer, Francesco Grandoni, Emmanuel Haefliger, Monika Nagy‐Hulliger, Jörg P. Halter, Jakob R. Passweg, David Haefliger, Carine Bardinet, Laurent A. Decosterd, Monia Guidi, François R. Girardin   +11 more
wiley   +1 more source

Serovars, Genetic Relatedness and Antimicrobial Resistance of Non-Typhoidal <i>Salmonella</i> in Poultry and Farm Workers in Southeastern Nigeria. [PDF]

Microorganisms
Okosi IR, Okorie-Kanu OJ, Majesty-Alukagberie L, Eze CM, Anyaoha C, Nwobi OC, Onwumere-Idolor O, Ogunniran TM, Anosa GN, Olubade-Olatokunbo T, Ugboh O, Okafor SC, Okoroafor O, Ikena-Ezeh NH, Okafor UC, Anyanwu MU, Okpala COR.   +16 more
europepmc   +1 more source

Clinical Characterization of Enzyme and Transporter Precipitants to Evaluate Drug–Drug Interactions for Orforglipron, a Small Molecule Glucagon‐Like Peptide‐1 Receptor Agonist

Clinical Pharmacology &Therapeutics, EarlyView.
Orforglipron is an orally administered, small‐molecule glucagon‐like peptide‐1 receptor agonist in clinical development for the treatment of type 2 diabetes and obesity. Orforglipron is a substrate of CYP3A4, organic anion transporting polypeptides (OATPs) 1B/1B3, and P‐glycoprotein (P‐gp); however, precipitants commonly used to define these mechanisms
Bridget L. Morse, David E. Coutant, Xiaosu Ma, Sohini Raha, Keerthan Aithal, Clare Nicoll, Luc R. A. Rougée, Shobha Bhattachar   +7 more
wiley   +1 more source