Results 51 to 60 of about 5,378,319 (398)
Comparing the Compensation of Federal and Private-Sector Employees [PDF]
, 2012 [Excerpt] The federal government competes with private-sector employers and state and local governments to attract and retain workers with the talents, skills, and experience that it needs to operate effectively.
Congressional Budget Office
core +1 more source
The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity
Molecular Oncology, EarlyView.Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli +7 more
wiley +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Constitutional Challenges of Creating New Local Government Areas in Nigeria
Commonwealth Journal of Local Governance, 2012 Local government is purposely established by law to provide grassroots development. In federal states, it is usually created by law of the federating units, and in unitary states it is created by central government.
Jude Okafor
doaj +1 more source
Post-Employment, “Revolving Door,” Laws for Federal Personnel [PDF]
, 2014 [Excerpt] Conflict of interest regulations and restrictions on certain private employment opportunities for a federal officer or employee do not necessarily end with the termination of the officer’s or employee’s federal service.
Maskell, Jack
core +2 more sources
HSP70 governs permeability and mechanotransduction in primary human endothelial cells
FEBS Open Bio, EarlyView.HSP70 chemical inhibition reduces endothelial cell proliferation and increases permeability, the latter supported by normal interendothelial junctional protein distribution. HSP70 also plays a role in shear stress response, a hemodynamic force naturally present in blood vessels and correlated with vessel protection.
Andrea Pinto‐Martinez +5 more
wiley +1 more source
Molecular determinants of signal transduction in tropomyosin receptor kinases
FEBS Open Bio, EarlyView.Tropomyosin receptor kinases control critical neuronal functions, but how do the same receptors produce diverse cellular responses? This review explores the structural mechanisms behind Trk signaling diversity, focusing on allosteric modulation and ligand bias.
Giray Enkavi
wiley +1 more source
Pakistan Federal Government [PDF]
, 2012 This document reports on a Public Financial Management and Accountability Assessment (PFMAA) for the Federal Government of Pakistan (GoP). Measured against the six core Public Financial Management (PFM) objectives examined by the assessment, the assessment indicates that there have been ...
Government of Pakistan +4 more
openaire +3 more sources
GMS Journal for Medical EducationAims: Comprehensive provision of general healthcare (i.e. primary care) within the populace is contingent on there being enough general practitioners (GPs) in proximity to patients.
Rass, Simon +2 more
doaj +1 more source
Enhancing federal inter-governmental relations and state building in Somalia
Humanities & Social Sciences Communications, 2023 Federalism is regarded as the ideal strategy for Somalia in forming a power-sharing agreement among Somali clans and a workable solution to the national unity, peace and security.
Mohamed Bile Hashi, Tiberius Barasa
doaj +1 more source