Results 31 to 40 of about 35,060 (232)
Prospecting the protein design landscape
FEBS Letters, EarlyView.This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona +4 more
wiley +1 more source
A Persistence Detector for Metabolic Network Rewiring in an Animal
Cell Reports, 2019 Summary: Biological systems must possess mechanisms that prevent inappropriate responses to spurious environmental inputs. Caenorhabditis elegans has two breakdown pathways for the short-chain fatty acid propionate: a canonical, vitamin B12-dependent ...
Jote T. Bulcha +8 more
doaj +1 more source
Nature Communications, 2021 HIF1alpha is reported to drive tumourigenesis through activating glycolysis. Here, the authors show that HIFAL, the HIF1alpha antisense long non-coding RNA, and HIF1alpha form a positive feed-forward loop which is essential for HIF1a-mediated metabolic ...
Fang Zheng +13 more
doaj +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Development of a 3-PRR Precision Tracking System with Full Closed-Loop Measurement and Control
Sensors, 2019 A 3-PRR (three links with each link consisting of a prismatic pair and two rotating pairs) parallel platform was designed for application in a vacuum environment.
Ling-bo Xie +2 more
doaj +1 more source
microRNA-Mediated Encoding and Decoding of Time-Dependent Signals in Tumorigenesis
Biomolecules, 2022 microRNAs, pivotal post-transcriptional regulators of gene expression, in the past decades have caught the attention of researchers for their involvement in different biological processes, ranging from cell development to cancer.
Simone Tealdi +3 more
doaj +1 more source
FEBS Open Bio, EarlyView.The presence of biotin‐binding avidin proteins in fish and their biological significance are poorly characterized. We cataloged fish avidins and demonstrate that they are widely present and evolutionarily conserved. We created avd knockout zebrafish and show that zebavidin is dispensable for development and that resistance of avd knockout embryos in ...
Anni K. Saralahti +5 more
wiley +1 more source
Robustness Analysis for Sundry Disturbed Open Loop Dynamics Using Robust Right Coprime Factorization
AxiomsIn this paper, the robustness of a system with sundry disturbed open loop dynamics is investigated by employing robust right coprime factorization (RRCF).
Yuanhong Xu, Mingcong Deng
doaj +1 more source
Noise decomposition principle in a coherent feed-forward transcriptional regulatory loop
Frontiers in Physiology, 2016 Coherent feed-forward loops exist extensively in realistic biological regulatory systems, and are common signaling motifs. Here, we study the characteristics and the propagation mechanism of the output noise in a coherent feed-forward transcriptional ...
Ming Yi
doaj +1 more source
Statecharts for gene network modeling. [PDF]
PLoS ONE, 2010 State diagrams (stategraphs) are suitable for describing the behavior of dynamic systems. However, when they are used to model large and complex systems, determining the states and transitions among them can be overwhelming, due to their flat ...
Yong-Jun Shin, Mehrdad Nourani
doaj +1 more source