Results 51 to 60 of about 786,189 (305)
Influence of cutting parameters and tool wear on the surface integrity of cobalt-based Stellite 6 alloy when machined under a dry cutting environment [PDF]
, 2016 The efficiency of a machining process can be measured by evaluating the quality of the machined surface and the tool wear rate. The research reported herein is mainly focused on the effect of cutting parameters and tool wear on the machined surface ...
Alexander Galloway +19 more
core +1 more source
Time after time – circadian clocks through the lens of oscillator theory
FEBS Letters, EarlyView.Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo +2 more
wiley +1 more source
FEBS Letters, EarlyView.Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson +7 more
wiley +1 more source
Processing and Microstructure of WC-CO Cermets by Laser Engineering Net Shaping [PDF]
, 2008 Submicron-sized tungsten carbide-cobalt (WC-Co) powder and nanostructured WC-Co powder were applied to make thick wall samples by the Laser Engineered Net Shaping (LENS®) process.
Lavernia, E. J. +3 more
core +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Study Regarding the Optimization of Milling Parameters for a Minimal Power Consumption [PDF]
Pro Ligno, 2018 Energy consumption has become one of the environmental issues regarding all industries because of the increased development that is recorded in the last years.
Sergiu RACASAN
doaj
Portable machine welding head automatically controls arc [PDF]
, 1967 Portable weld tool makes weld repairs out-of-station and on the side opposite the original weld. It provides full automatic control of the arc voltage, current, wire feed, and electrode travel speed in all welding attitudes.
Oleksiak, C. E., Robb, M. A.
core +1 more source
Price Discovery and the Accuracy of Consolidated Data Feeds in the U.S. Equity Markets
, 2018 Both the scientific community and the popular press have paid much attention to the speed of the Securities Information Processor, the data feed consolidating all trades and quotes across the US stock market.
Bergen-Hill, Tobin A. +9 more
core +1 more source
Molecular Oncology, EarlyView.Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley +5 more
wiley +1 more source