Results 41 to 50 of about 1,095,705 (250)

A nonlinear optimal control approach for the pulping process of paper mills

IET Collaborative Intelligent Manufacturing, 2021
The mechanical pulping process is non‐linear and multivariable. To solve the related control problem, the dynamic model of the pulping process undergoes first approximate linearization around a temporary operating point which is updated at each iteration
G. Rigatos, M. Abbaszadeh, G. Cuccurullo, P. Siano   +3 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Robust Feedback Linearization Based Disturbance Observer Control of Quadrotor UAV

IEEE Access
This paper presents a novel Robust Feedback Linearization (RFBL) controller for Quadrotor Unmanned Aerial Vehicle (UAV) when subjected to external disturbances.
Mohammad Sadiq, Rameez Hayat, Kamran Zeb, Ahmed Al-Durra, Zahid Ullah   +4 more
doaj   +1 more source

Design of an Adaptive-Neural Network Attitude Controller of a Satellite using Reaction Wheels

Journal of Applied and Computational Mechanics, 2015
In this paper, an adaptive attitude control algorithm is developed based on neural network for a satellite using four reaction wheels in a tetrahedron configuration.
Abbas Ajorkar, Alireza Fazlyab, Farhad Fani saberi, Mansour Kabganian   +3 more
doaj   +1 more source

Feedback Linearization in Systems with Nonsmooth Nonlinearities [PDF]

, 2016
This paper aims to elucidate the application of feedback linearization in systems having nonsmooth nonlinearities. With the aid of analytical expressions originating from classical feedback linearization theory, it is demonstrated that for a subset of ...
Paoletti, P, Mottershead, JE, Jiffri, S
core   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Feedback linearization and equivalent-disturbance compensation control strategy for piezoelectric stage

Nanotechnology and Precision Engineering
Piezoelectric stages use piezoelectric actuators and flexure hinges as driving and amplifying mechanisms, respectively. These systems have high positioning accuracy and high-frequency responses, and they are widely used in various precision/ultra ...
Tao Huang, Yingbin Wang, Zhihong Luo, Huajun Cao, Guibao Tao, Mingxiang Ling   +5 more
doaj   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Generalized Quadratic Linearization of Machine Models

Journal of Control Science and Engineering, 2011
In the exact linearization of involutive nonlinear system models, the issue of singularity needs to be addressed in practical applications. The approximate linearization technique due to Krener, based on Taylor series expansion, apart from being ...
Parvathy Ayalur Krishnamoorthy, Kamaraj Vijayarajan, Devanathan Rajagopalan   +2 more
doaj   +1 more source