Results 91 to 100 of about 78,479 (285)

Late Pliocene lakes and soils: a global data set for the analysis of climate feedbacks in a warmer world [PDF]

open access: yes, 2014
The global distribution of late Pliocene soils and lakes has been reconstructed using a synthesis of geological data. These reconstructions are then used as boundary conditions for the Hadley Centre General Circulation Model (HadCM3) and the BIOME4 ...
H. J. Dowsett   +17 more
core   +2 more sources

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

open access: yesMolecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez   +5 more
wiley   +1 more source

Atmospheric radiative feedbacks associated with transient climate change and climate variability

open access: yes, 2010
This study examines in detail the 'atmospheric' radiative feedbacks operating in a coupled General Circulation Model (GCM). These feedbacks (defined as the change in top of atmosphere radiation per degree of global surface temperature change) are due to ...
Colman, Robert A., Power, Scott B.
core   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim   +17 more
wiley   +1 more source

Deforestation-induced runoff changes dominated by forest-climate feedbacks

open access: yes
Large-scale deforestation alters water availability through its direct effect on runoff generation and indirect effect through forest-climate feedbacks. However, these direct and indirect effects and their spatial variations are difficult to separate and
Zhou, S, Ma, S, Song, J, Yu, B
core   +1 more source

Root-exuded benzoxazinoids can alleviate negative plant–soil feedbacks [PDF]

open access: yes
- Plants can suppress the growth of other plants by modifying soil properties. These negative plant–soil feedbacks are often species-specific, suggesting that some plants possess resistance strategies.
Erb, Matthias   +2 more
core   +2 more sources

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

open access: yesFEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz   +6 more
wiley   +1 more source

Deforestation Could Push Amazonia Close to a Tipping Point Under Future Climate Change

open access: yesGeophysical Research Letters
We use a coupled land‐surface‐atmosphere single‐column model to examine the effects of deforestation and changed advective moisture flux (AMF) on the Amazonian system.
László Hunor Hajdu   +3 more
doaj   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

open access: yesFEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj   +3 more
wiley   +1 more source

COMPUTER TECHNOLOGIES IN LINE STRUCTURE ROUTING

open access: yesРоссийский технологический журнал, 2017
Under study are two approaches to creating computer programs for computer-aided design of linear structures trails. The first approach, which realised in the existing CAD of linear structures, is not focused on the optimization of the design decisions ...
V. I. Struchenkov
doaj   +1 more source

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