Results 101 to 110 of about 78,479 (285)

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Feedbacks classification.

, 2016
Feedbacks classification.
Yuri Kosinsky (1778548), Andrei Raigorodskii (2145553), Vadim Govorun (2131033), Dmitry Ischenko (2145547), Dmitry Alexeev (1535380), Tatiana Shashkova (2145550), Lev Bogolubsky (2145544), Alexander Tyakht (2131003), Kirill Peskov (2145541), Anna Popenko (2131006)   +9 more
core   +1 more source

Biotic plant-soil feedbacks across temporal scales

, 2013
Synthesis. Based on our synthesis of temporal aspects of plant-soil feedbacks, we suggest three main avenues for future research: (i) how plant-soil feedbacks changes with ontogeny, (ii) how plant and soil organism traits drive temporal variation in ...
Sveriges lantbruksuniversitet., Kardol, Paul,   +1 more
core   +2 more sources

Hysteresis of the Antarctic Ice Sheet With a Coupled Climate‐Ice‐Sheet Model

Geophysical Research Letters
The stability of the Antarctic ice sheet under different fixed CO2 levels and orbital configurations is explored using a coupled climate‐ice sheet model, starting from either a pre‐industrial ice sheet or an ice‐free, isostatically rebounded geometry ...
G. Leloup, A. Quiquet, D. M. Roche, C. Dumas, D. Paillard   +4 more
doaj   +1 more source

Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA

FEBS Open Bio, EarlyView.
PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro, Fernando Lucas Palhano   +1 more
wiley   +1 more source

Irrigation experiments in the lab: trust, environmental variability, and collective action

Ecology and Society, 2015
Research on collective action and common-pool resources is extensive. However, little work has concentrated on the effect of variability in resource availability and collective action, especially in the context of asymmetric access to resources.
Jacopo A. Baggio, Nathan D. Rollins, Irene Pérez, Marco A. Janssen   +3 more
doaj   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

Positive Feedbacks

, 2017
This chapter examines the main mechanisms leading to positive feedbacks, that is, self-reinforcement, such as imitative behavior and herding between investors.
Didier Sornette
core   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

Synthesis of human-nature feedbacks

, 2015
In today’s globalized world, humans and nature are inextricably linked. The coupled human and natural systems (CHANS) framework provides a lens with which to understand such complex interactions.
Jianguo Liu, Vanessa Hull, Mao-Ning Tuanmu   +2 more
core   +1 more source