Results 41 to 50 of about 78,000 (262)

Maternal feeding styles and the risk of overweight in a cohort of Caribbean infants

Lifestyle Medicine, 2023
Introduction Parental feeding styles in the first years of life may increase childhood overweight risk. There are few studies on this association in children under 2 years.
Amika S. Wright, Marshall K. Tulloch‐Reid, Susan M. Chang, Susan P. Walker   +3 more
doaj   +1 more source

Water Surface Behaviour of Irrawaddy Dolphin Orcaella brevirostris (Owen in Gray, 1866) and Influencing Factors in the Bay of Brunei, Brunei Darussalam

Journal of Marine Science and Engineering, 2022
There is limited information on Irrawaddy dolphins (Orcaella brevirostris) in the Bay of Brunei, Brunei Darussalam. This research was carried out from 2016 to 2018 to determine the water surface behaviour of Irrawaddy dolphins in the bay, the ...
Nurlisa Azizul, Saifullah Arifin Jaaman, Farah Dayana Haji Ismail, Azmi Marzuki Muda, Xuelei Zhang, Hairul Masrini Muhamad, Mohammad Vol Momin, Bohari Abdullah   +7 more
doaj   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Preliminary Observations of Environmental Effects on Immature Whale Shark Surface Feeding Behaviour in Nosy Be, Madagascar

Diversity
Nosy Be in the northwestern Madagascar hosts one of the largest known seasonal feeding aggregations of whale sharks. However, the environmental drivers influencing whale shark surface feeding behaviour in this area remain poorly understood.
Primo Micarelli, Andrea Marsella, Federica Sironi, Isabella Buttino, Stefano Aicardi, Antonio Pacifico, Francesca Ellero, Francesca Romana Reinero   +7 more
doaj   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Erythropoietin modulates hepatic inflammation, glucose homeostasis, and soluble epoxide hydrolase and epoxides in high‐fat diet‐induced obese mice

FEBS Open Bio, EarlyView.
Erythropoietin administration suppresses hepatic soluble epoxide hydrolase (sEH) expression, leading to increased CYP‐derived epoxides. This is associated with a shift in hepatic macrophage polarization characterized by reduced M1 markers and increased M2 markers, along with reduced hepatic inflammation, suppressed hepatic lipogenesis, and attenuated ...
Takeshi Goda, Satoru Sugimoto, Chiharu Cho, Madoka Konishi, Nozomi Inoue, Satoshi Miyagaki, Yasuhiro Kawabe, Takuro Okamura, Masahide Hamaguchi, Hisakazu Nakajima, Michiaki Fukui, Masakazu Shinohara, Tomoko Iehara   +12 more
wiley   +1 more source

Manta munchies: plankton dynamics and feeding behaviour of reef manta rays (Mobula alfredi) around D’Arros Island in the Seychelles

Frontiers in Marine Science
The reef manta ray (Mobula alfredi) is a threatened filter-feeding elasmobranch that requires immediate management and protection across large parts of its range. Despite being well-studied, a detailed understanding of their feeding ecology, which shapes
Dillys K. Pouponeau, Dillys K. Pouponeau, Dillys K. Pouponeau, Joanna L. Harris, Joanna L. Harris, Henriette M.V. Grimmel, Ellie E. Moulinie, Robert W. Bullock, Robert W. Bullock   +8 more
doaj   +1 more source

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

FEBS Open Bio, EarlyView.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen, Qianqian Cui, Zhongyun Lan, Yingjun Wang, Shuaiying Zhao, Wenxuan Feng, Yunfeng Liu, Qiting Huang, Dongna Zhang, Jianfeng Xu   +9 more
wiley   +1 more source