Results 61 to 70 of about 494,639 (307)

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Seasonal change in the daily timing of behaviour of the common vole, Microtus arvalis [PDF]

, 1984
1. Seasonal effects on daily activity patterns in the common vole were established by periodic trapping in the field and continuous year round recording of running wheel and freeding activity in cages exposed to natural meteorological conditions.
AD Rijnsdorp, CCK Leuze, CN Rowsemitt, CS Pittendrigh, DM Madison, DM Osterberg, E Erkinaro, E Erkinaro, E Erkinaro, ES Nyholm, FA Chute, G Londo, GJ Kenagy, I. Hoogenboom, J Aschoff, J Bovet, J Kikkawa, J. H. Dallinga, JA Robitaille, K Ostermann, KD Taylor, L Hansson, LA Maynard, LE Brown, LL DeKock, LL Stebbins, M. Schoenmakers, OP Pearson, RUG/RIJP Raptor-group, S Daan, S Daan, S. Daan, TB Herman, TCR White, U Lehmann, U Lehmann, W Bäumler   +36 more
core   +3 more sources

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

The distribution of estuarine fish larvae: nutritional condition and co-occurrence with predators and prey [PDF]

, 2000
Fish larvae were collected monthly between March and September 1997 in the Mira and Guadiana estuaries (southern Portugal). Hydrological parameters were registered and zooplankton samples were obtained simultaneously. Densities of fish larvae (ind.100 m(-
Antunes, Baier, Bailey, Bain, Battini, Bergeron, Blaxter, Brodeur, Buckley, Bulow, Bulow, Buskey, Caldarone, Canino, Canino, Chícharo, Chícharo, Chícharo, Conover, Conway, Costa, Crecco, Crecco, Crecco, DeVries, Eduardo Esteves, Esteves, Ferreira, Fives, Fortier, Frank, Frank, Frank, Hjort, Hjort, Holmes, Houde, Houde, Hugie, Hunter, Hunter, Hunter, J.Pedro Andrade, Knox, Lasker, Laurence, M.Alexandra Chícharo, Martin, Matsakis, McGurk, Mclusky, Moller, Newell, Omori, Palmer, Palomera, Pepin, Pestana, Peterson, Purcell, Purcell, Robinson, Russell, Ré, Ré, Saville, Scheidegger, Schneider, Sinclair, Sinclair, Smith, Snedecor, SPSS, Stein, Suthers, Taggart, Teresa Pina, Thiel, Todd, Turner, van der Veer, Wyatt, Zar   +82 more
core   +2 more sources

Preliminary Observations of Environmental Effects on Immature Whale Shark Surface Feeding Behaviour in Nosy Be, Madagascar

Diversity
Nosy Be in the northwestern Madagascar hosts one of the largest known seasonal feeding aggregations of whale sharks. However, the environmental drivers influencing whale shark surface feeding behaviour in this area remain poorly understood.
Primo Micarelli, Andrea Marsella, Federica Sironi, Isabella Buttino, Stefano Aicardi, Antonio Pacifico, Francesca Ellero, Francesca Romana Reinero   +7 more
doaj   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Reducing cross-sucking of group housed calves by an environmental enriched building design [PDF]

, 2007
Group housing is a natural and economic way of raising calves. One major disadvan-tage of group housing calves is the occurrence of cross-sucking as an abnormal behaviour. The main objective of our study on organic calf housing was the reduction of cross-
Georg, Heiko, Ude, Gracia
core  

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

The 5-HT2C receptor agonist, lorcaserin, and the 5-HT6 receptor antagonist, SB-742457, promote satiety; a microstructural analysis of feeding behaviour [PDF]

, 2015
RATIONALE: Whilst the FDA-approved anorectic, lorcaserin and various 5-hydroxytryptamine (5-HT)6 receptor antagonists reduce feeding, a direct assessment of their impact upon feeding behaviour is less clear. We therefore examined the action of lorcaserin
Alison J. Cooper, Nicholas M. Barnes, Suzanne Higgs   +2 more
core   +2 more sources