Results 61 to 70 of about 345,453 (201)
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Feeling The Right Way: Normative influences on people’s use of emotion concepts [PDF]
, 2020 It is generally assumed that emotion concepts merely encode descriptive information about agents’ psychological or bodily states. Recent investigations have challenged this assumption, claiming that the folk concept of happiness also includes information
Diaz Martin, Rodrigo Jesús +4 more
core +2 more sources
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
Kierkegaard: a ambigüidade da imaginação Kierkegaard: the ambiguity of imagination
Trans/Form/Ação, 2003 O tema principal deste trabalho é a compreensão kierkegaardiana da imaginação e a estrutura da dialética da imaginação nos estádios estético e religioso.The main theme of this paper is Kierkegaard´s understanding of the imagination and the structure of ...
Silvia Saviano Sampaio
doaj +1 more source
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
L’immaginario del Made in Italy. Note per un progetto di ricerca
Im@go. A Journal of the Social Imaginary, 2017 In recent years, the “Made in Italy” has become a kind of powerful across-the-board brand able to give Italian products a collective “aura” of quality and prestige.
Fulvio Carmagnola
doaj
Feeling it out : Clark Beaumont [PDF]
, 2014 This catalogue essay was written to accompany Clark Beaumont's 2014 exhibition at Kings Artist Run in Melbourne, 'Feeling It Out'. It contextualises Clark Beaumont's work within a history of women's participation and achievement in modern and ...
Pedersen, Courtney Brook
core
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
FEBS Letters, EarlyView.How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley +1 more source
The Feeling of Alienation in the Namesake by Jhumpa Lahiri [PDF]
, 2014 Alienation is an unavoidable aspect of modern life Nevertheless it is as old as human beings themselves The analysis of the interaction between the two sides the oppressors - the oppressed thesis-antithesis sheds lights on the emergence of ...
A.Vahap(Abdulvahap) SONMEZ +1 more
core