Results 41 to 50 of about 1,518,423 (359)
A subset of MMR‐proficient colon cancers responds to neoadjuvant immunotherapy
Molecular Oncology, EarlyView.Tan et al. reveal that a distinct subset of early‐stage pMMR colon cancers can respond to neoadjuvant immunotherapy. In the NICHE‐2 trial, responders (26%) were characterized by chromosomal instability, TP53 mutations, and proliferative cell‐cycle programs, whereas nonresponders showed metabolic and stromal reprogramming with TGF‐β‐driven ...
Eleonora Piumatti +3 more
wiley +1 more source
Romanian and Hungarian Fiscal Systems. Regulations and Fiscal Apparatus
Bulletin of the Transilvania University of Braşov: Series VII: Social Sciences, Law, 2020 Romania and Hungary had to face the challenges determined by the transition to the new political, economic, and social systems and to set up fiscal systems and fiscal administrations to ensure the public revenues necessary to cover public expenditures.
R. Ciobanu, Z. Varga
doaj +1 more source
Molecular Oncology, EarlyView.Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon +9 more
wiley +1 more source
INSTITUTIONAL CHANGE AS A STRATEGIC OPTION IN THE ACTIVITY OF THE STATE TAX SERVICE [PDF]
Economica, 2021 The latest processes, which take place in the socio-economic and political system of the country, determine the State Tax Service to be much more transparent and dynamic in its activity.
Igor TURCANU
doaj
The relationship between non-audit service fees and audit fees in the banking sector in Malaysia [PDF]
, 2006 The issue of audit fees and non-audit fees charged by the audit firms has been discussed regularly in accounting and auditing literature. Recently, due to the corporate scandals in United States, the issue is discussed together with a host of revelations
Che Ahmad, Ayoib +2 more
core +1 more source
The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity
Molecular Oncology, EarlyView.Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli +7 more
wiley +1 more source
Scientific Reports, 2022 Flexible endoscopic evaluation of swallowing (FEES) is considered the gold standard in diagnosing oropharyngeal dysphagia. Recent advances in deep learning have led to a resurgence of artificial intelligence-assisted computer-aided diagnosis (AI-assisted
Weihao Weng +3 more
doaj +1 more source
Cutaneous Melanoma Drives Metabolic Changes in the Aged Bone Marrow Immune Microenvironment
Aging and Cancer, EarlyView.Melanoma, the deadliest form of skin cancer, increasingly affects older adults. Our study reveals that melanoma induces changes in iron and lipid levels in the bone marrow, impacting immune cell populations and increasing susceptibility to ferroptosis.
Alexis E. Carey +12 more
wiley +1 more source
Analysis of Local Taxes in the European Union [PDF]
Ovidius University Annals: Economic Sciences Series, 2016 The fiscal system can be used as a tool for economic life regulation, for the state interventionin the economy in order to eliminate the imbalances in different periods of economic life.
Oana Oprisan +2 more
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BMJ Open, 2023 Objectives Patients missing their scheduled appointments in specialist healthcare without giving notice can undermine efficient care delivery. To reduce patient non-attendance and possibly compensate healthcare providers, policy-makers have noted the ...
Eli Feiring, Joar Røkke Fystro
doaj +1 more source