Results 61 to 70 of about 112,000 (305)

Modern approaches to infertility in male and female

, 2023
Infertility is a major public health concern around the world and is defined as the inability to conceive after 12 months of regular, unprotected sexual activity without the use of contraception.
Slouk, Amit
core  

Does the “delayed start” protocol with gonadotropin-releasing hormone antagonist improve the pregnancy outcome in Bologna poor responders? a randomized clinical trial

Reproductive Biology and Endocrinology, 2018
Background Recently, a novel approach with delaying the start of controlled ovarian stimulation along with gonadotropin-releasing hormone (GnRH) antagonist pretreatment for 7 days after estrogen priming for further suppression of endogenous follicle ...
Mahnaz Ashrafi, Arezoo Arabipoor, Azar Yahyaei, Zahra Zolfaghari, Firouzah Ghaffari   +4 more
doaj   +1 more source

Increasing The Number of Embryos Transferred from Two to Three, Does not Increase Pregnancy Rates in Good Prognosis Patients [PDF]

International Journal of Fertility and Sterility, 2015
Background To compare the pregnancy outcomes after two embryos versus three embryos transfers (ETs) in women undergoing in vitro fertilization (IVF)/intracytoplasmic sperm injection (ICSI) cycles.
Mahnaz Ashrafi, Tahereh Madani, Mina Movahedi, Arezoo Arabipoor, Leili Karimian, Elaheh Mirzaagha, Mohammad Chehrazi   +6 more
doaj   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Introduce an optimal method of ovarian stimulation in the polycystic ovarian syndrome affected: a randomized controlled trial

BMC Women's Health, 2023
Background Currently, optimal method of ovarian stimulation (OS) to in-vitro fertilization (IVF) in the patients with polycystic ovarian syndrome (PCOS) is unknown.
Azar Yahyaei, Samira Vesali, Firouzeh Ghaffari   +2 more
doaj   +1 more source

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

Infertility and its management from a pharmacological perspective

, 2023
Infertility is defined as the inability to conceive after at least 12 months of regular and unprotected sexual intercourse. Infertility is a medical problem of increasing prevalence and is estimated to affect 8-12% of couples of reproductive age ...
Dagsson, Gunnar Þór
core  

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

Molecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel, Izabela Kubiak, Lena Rutkowska, Żaneta Kasprzyk, Łukasz Kępczyński, Michał Bednarek, Dariusz Sobieraj, Jacek Wilkosz, Piotr Kania, Adam Jędrzejczyk, Bogdan Kałużewski, Agnieszka Gach, Tadeusz Kałużewski   +12 more
wiley   +1 more source

Non-syndromic monogenic female infertility

, 2019
Infertility is a significant clinical problem. It affects 8-12% of couples worldwide, about 30% of whom are diagnosed with idiopathic infertility (infertility lacking any obvious cause).
Bertelli, Matteo, Della Morte, Chiara, Garzon S., Bertelli M., Guerri G., Di Renzo, Gian Carlo, Sturla D., Lagana A. S., Sturla, Davide, Casadei, Arianna, Unfer, Vittorio, Casadei A., Barati, Shila, Ghezzi F., Di Renzo G. C., Paolacci S., Marceddu, Giuseppe, Renzo, Gian Carlo Di, Morte, Chiara Della, Guerri, Giulia, Barati S., Maniscalchi, Tiziana, Marceddu G., Laganà, Antonio Simone, Gerli S., Morte C. D., Ghezzi, Fabio, Garzon, Simone, Unfer V., Maniscalchi T., Gerli, Sandro   +30 more
core   +1 more source