Results 41 to 50 of about 2,052,375 (260)

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

open access: yesFEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

open access: yesMolecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Tenth Scientific Biennial Meeting of the Australasian Virology Society—AVS10 2019

open access: yesViruses, 2020
The Australasian Virology Society (AVS) aims to promote, support and advocate for the discipline of virology in the Australasian region. The society was incorporated in 2011 after 10 years operating as the Australian Virology Group (AVG) founded in 2001,
Karla J. Helbig   +29 more
doaj   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

open access: yesMolecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge   +17 more
wiley   +1 more source

Five Students of San Antonio Female College

open access: yes, 1915
Photograph of five students from San Antonio Female College, taken around 1915. They are identified on the back of the photograph as: [back row, left to right] Ann DePraslin, Lois Goddard, Viola Drew; [front row, left to right] Frances Lyles, Helen ...
San Antonio Female College
core   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

open access: yesMolecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura   +19 more
wiley   +1 more source

Allá en el setenta y tantos (1945). Female Pioneers in Argentinian Cinema

open access: yesRevista de Medicina y Cine / Journal of Medicine and Movies, 2016
This paper recovers an exceptional homage paid by Argentinian cinema in 1945 to three medical pioneers of that country: Élida Passo, Cecilia Grierson and Elvira Rawson Guiñazú.
Alberto Enrique D’OTTAVIO CALLEGARI
doaj  

Women in Dentistry: From Historical Milestones to Leadership in the Sustainable Development Goals of the 2030 Agenda

open access: yesAdministrative Sciences
This review offers a historical overview of the role of women in the modern dental profession, tracing their journey from the earliest pioneers to the present day and highlighting their significant achievements.
Rocío Trinidad Velázquez-Cayón   +1 more
doaj   +1 more source

A Political End to a Pioneering Career: Marianne Beth and the Psychology of Religion

open access: yesReligions, 2011
Although forgotten in both Religionswissenschaft (the Science of Religion) and psychology, Marianne Beth (1880-1984), initially trained as a lawyer and already in 1928 called a “leading European woman”, must be considered as one of the female pioneers of
Jacob A. Belzen
doaj   +1 more source

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

open access: yesMolecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens   +6 more
wiley   +1 more source

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