Results 61 to 70 of about 7,758 (255)
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
BOOK REVIEW: The Encyclopedia of Female Pioneers in Online Learning
Journal of Learning for Development, 2023 Karen Nyangara
doaj +1 more source
« Equal Pay! ». Le combat de la United States Women’s National Team mis en perspective
Football(s)Based on numerous interviews with pioneers of the United States Women's National Team (USWNT) from the 1980s, as well as institutional and academic actors engaged in the fight for gender equality in sport, the article traces the origins of American ...
Jane McManus
doaj +1 more source
Pioneer women in the development of toxicology in Brazil [PDF]
Brazilian Journal of Medical and Biological ResearchWomen have always played an important role in the development of toxicology all over the world. Specifically in Brazil, toxicology has had greater female representation than other countries, but women's participation at high hierarchical levels is low ...
L. Melo, T.S. Melo
doaj +2 more sources
Dorothy Mackay: A Forgotten Female Pioneer in Archaeology
Muzeológia a kultúrne dedičstvo, 2023 In 2022, the author of this paper came across four letters regarding epigraphic documentation of some elite tombs in the Theban necropolis, Egypt, written by Dorothy Mackay and addressed to Alan H. Gardiner, at the archive of the Griffith Institute, University of Oxford.
openaire +2 more sources
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
Alice Salomon (Germany), President 1928/29-1946
Social Work and Society, 2008 Salomon belongs to the known and nevertheless unknown 'pioneers' of social work in the world. She founded one of the first Schools of Social Work (Berlin 1908) and was the first president of the International Association of Schools of Social Work ...
Carola Kuhlmann
doaj +2 more sources