Results 71 to 80 of about 3,037,859 (309)

Ameliorative Effects of Moringa oleifera Supplementation on Metabolic, Oxidative, and Reproductive Alterations Induced by Feed Restriction in Female Rats [PDF]

Journal of Applied Veterinary Sciences
Nutritional stress such as feed restriction can negatively affect metabolic balance, oxidative status, and reproductive function, particularly in females. Moringa oleifera is a natural supplement rich in antioxidants and bioactive compounds that may help
Manal Bakeer, Aya Hendawy
doaj   +1 more source

Soursop leaf extract increases neuroglia and hepatic degeneration in female rats [PDF]

Universa Medicina, 2015
Background Soursop leaf contains annonaceous acetogenins and alkaloids. The acetogenins act as inhibitors of mitochondrial complex I, suppress ATP production and cause cell degeneration, whereas the alkaloids act as neurotoxins.
Ety Sari Handayani, Zainuri Sabta Nugraha, Ika Fidianingsih, Prilly Raleka Pahlevawati   +3 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

PALM DATE KERNELS AS UNCONVENTIONAL FUNCTIONAL FOOD INGREDIENT OF NATURAL PHYTOESTROGEN IMPROVING HEALTH OF MENOPAUSES FEMALE RATS

Journal of Productivity and Development, 2008
This study was conducted to fined out probable benefit of palm date kernels phoenix dactylifera  representing natural estrogen since for  menopausal rats( 205± 2g each) .Kernel, of two varieties of ripe palm date were used, which were Amhat and Zaghlool .
Asmaa Moath, Tarek Abd El-Rahman, Mohamed Ali   +2 more
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Effect of long-term inorganic nitrate administration on myocardial ischemia-reperfusion injury in ovariectomized rats

Frontiers in Pharmacology
Introduction: Menopause is associated with reduced nitric oxide (NO) bioavailability and lower tolerance against myocardial ischemia-reperfusion (IR) injury.
Sajad Jeddi, Nasibeh Yousefzadeh, Maryam Zarkesh, Khosrow Kashfi, Asghar Ghasemi   +4 more
doaj   +1 more source

SHELL Part of Nucleus Accumbens and Its Laterality Has Important Role in Response to Chronic Stress in Female Rats [PDF]

Brazilian Archives of Biology and Technology
The nucleus accumbens shell (NAcSh) plays a role in appetitive and negative motivation with sex differences in responses. NAcSh and its laterality in metabolic and hormonal responses to chronic stress in female rats is evaluated via transient ...
Tahereh-Sadat Javadifar, Mehdi Amirikia, Nahid Sarahian, Mohammad-Ali Ketabi, Hedayat Sahraei, Mohammad Nasehi, Mohammad-Reza Zarrindast   +6 more
doaj   +2 more sources