Results 61 to 70 of about 2,157,838 (290)

Optimizing dog population control strategies in Thailand using mathematical and economic modeling.

PLoS Neglected Tropical Diseases
A mathematical model was constructed to investigate dog population dynamics and explore the impact of population management and rabies prevention. We aimed to evaluate cost-effective sterilization and vaccination strategies for dog population control and
Weerakorn Thichumpa, Anuwat Wiratsudakul, Saranath Lawpoolsri, Yanin Limpanont, Weerapong Thanapongtharm, Lauren M Smith, Sarawut Maneewong, Wirichada Pan-Ngum   +7 more
doaj   +1 more source

Discovery and Optimization of AMT‐676, a CDH17‐Targeting ADC for the Treatment of Advanced Gastrointestinal Cancers

Advanced Science, EarlyView.
AMT‐676 is a novel antibody‐drug conjugate targeting CDH17, an adhesion molecule uniquely exposed on gastrointestinal tumor surfaces. Engineered with an optimized exatecan payload, it demonstrates profound tumor regression and a robust bystander effect across diverse preclinical models.
Ying‐nan Wang, Dan‐yun Ruan, Jing Shi, Yue Huang, Hui Sheng, Ya‐ling Huang, Linjie Ma, Lijun Wang, Caiwei Chen, Yixuan Wang, Yue Zhang, Yi Shen, Qing Zhang, Jianjian Zhang, Yanfang Tang, Jin‐ling Zhang, Jia‐jia Hu, Chen‐yi Wu, Jia‐ying Chen, Xun Meng, Shu‐Hui Liu, Feng Wang   +21 more
wiley   +1 more source

Targeting the CRYAB/β‐Catenin Axis with an MMP‐9‐Responsive Hydrogel Disrupts CTC Clusters to Suppress Progression of Hepatocellular Carcinoma after Radiofrequency Ablation

Advanced Science, EarlyView.
The graphical abstract illustrates that sublethal thermal stress after iRFA upregulates the chaperone CRYAB in residual HCC cells, which stabilizes β‐catenin and drives a dual pathological program, including EMT and N2‐TAN polarization, thereby leading to heterotypic CTC cluster formation. The MMP‐9‐responsive hydrogel (XB@Gel) delivers XAV‐939 and BMS‐
Hui Chen, Danni Yang, Songying Pi, Yuhan Liu, Hongbin Huang, Feile Ye, Yuhong Lin, Zhongzhen Su, Yongquan Huang   +8 more
wiley   +1 more source

Non‐Invasively Quantitative Raman Imaging for Calculation of Lymphatic Transport Kinetics of Micelles in Mice

Advanced Science, EarlyView.
Non‐invasively quantitative Raman imaging with stacking‐induced charge transfer‐enhanced Raman scattering (SICTERS) enables accurate measurement of concentrations and pharmacokinetic modeling of lymphatic transport of micelles in mice. This platform allows dynamic analysis of nanoparticle transport and underpins the design of effective lymph node ...
Yunlu Li, Hongzheng Lin, Sheng Yu, Yunhui Liao, Teng Huang, Zeyu Xiao, Wei Lu   +6 more
wiley   +1 more source

Implementation of opportunistic salpingectomy for ovarian cancer prevention: Analyzing clinical practice and key characteristics

Acta Obstetricia et Gynecologica Scandinavica
Introduction Ovarian cancer (OC) is the most lethal gynecologic cancer, often diagnosed at an advanced stage due to nonspecific symptoms and lack of effective screening.
Charlotte Fisch, Malou E. Gelderblom, Brigitte Slangen, Angèle L. M. Oei, Alexandra A. vanGinkel, Huy Ngo, Joanne deHullu, Jurgen Piek, Rosella Hermens   +8 more
doaj   +1 more source

Study of sexual functioning and disorder in women before and after tubal sterilization (tubectomy)

Indian Journal of Psychiatry, 2017
Introduction: Sexual relationship is a basis for mental health and continuity of the healthy generation. There are very few studies on the female sexual functioning, especially in India.
Shweta Patil Kunkeri, T. S. Sathyanarayana Rao, Chittaranjan Andrade   +2 more
doaj   +1 more source

Postpartum sterilization: a five years retrospective study [PDF]

, 2018
Background: Female sterilization, which is also called tubal ligation or tubal occlusion, is a surgical procedure which aims at permanent contraception.
Sivanandan, Kotteeswari Palanisamy, Sengottian, Eswari, Dhanapal, Mohana, Murugesan, Praveena   +3 more
core   +1 more source

An Injectable, Self‐Expanding Hemostatic Foam for Field‐Compatible Postpartum Hemorrhage Management

Advanced Science, EarlyView.
Postpartum hemorrhage is the leading cause of maternal death worldwide, yet many treatments are hard to use outside well‐equipped hospitals. This work introduces an easy‐to‐use device that rapidly delivers a degradable foam into the uterus. The foam stops bleeding through pressure and clotting support, offering a practical option for low‐resource ...
Charlotte Meyer, Noël Strasser, Ilakkiya Ravindrarajah, Elsa Wrenger, Kristian Ivkovic, Jan Ševčík, Sima Šarčević, Lenka Červenková, Jáchym Rosendorf, Václav Liška, Alexandre H. Anthis, Thomas Rduch, Inge K. Herrmann   +12 more
wiley   +1 more source

Evaluation of a patient decision aid for opportunistic salpingectomy and salpingectomy as sterilization method to prevent ovarian cancer

Acta Obstetricia et Gynecologica Scandinavica
Introduction A patient decision aid on opportunistic salpingectomy and salpingectomy as a sterilization method has been developed to provide uniform counseling and reduce practice variation.
Malou E. Gelderblom, Charlotte Fisch, Jurgen M. J. Piek, Laura A. M. vanLieshout, Justine Briet, Lauren Bullens, Sjors F. P. J. Coppus, Inge Ebisch, Alexandra A. vanGinkel, Rafli van deLaar, Natascha deLange, Marloes Maassen, Huy Ngo, Angele L. M. Oei, Brenda Pijlman, Brigitte Slangen, Regina The, Dineke Smedts, Caroline Vos, Joanna IntHout, Joanne A. deHullu, Rosella P. M. G. Hermens   +21 more
doaj   +1 more source

Quality of care in sterilization services at the public health facilities in India: A multilevel analysis.

PLoS ONE, 2020
Female sterilization is the most popular contraceptive method among Indian couples, and the public sector is the major source of sterilization services in the country.
Vinod Joseph K J, Arupendra Mozumdar, Hemkhothang Lhungdim, Rajib Acharya   +3 more
doaj   +1 more source