Results 51 to 60 of about 659,413 (250)

The IRE1‐XBP1s Axis Drives Inflammatory Osteolysis by Regulating a 5‐HT Dependent Endogenous Anti‐Autophagy Mechanism

Advanced Science, EarlyView.
A previously unrecognized IRE1‐XBP1s‐Slc6a4 signaling axis links endoplasmic reticulum stress to serotonin metabolism, autophagy, and inflammatory osteoclastogenesis. By promoting intracellular serotonin uptake and reducing endogenous 3‐methyladenine accumulation, this pathway accelerates inflammatory bone destruction and provides a promising ...
Pengchao Yang, Binxiang Zhu, Yuzhi He, Yang Tian, Honglei Kang, Shian Hu, Pengju Wang, Yong Xu, Zhuowei Lei, Peijun Qi, Hao Yang, Yang Lin, Yimin Dong, Feng Li, Hanfeng Guan   +14 more
wiley   +1 more source

The design, manufacture and analysis of a new implant for fracture fixation in human and veterinary orthopaedic surgery: the bone fastenerod [PDF]

, 2002
Fracture fixation in humans and animals has troubled surgeons and scientists since first it was attempted right up to the present day. At every milestone of achievement in the understanding and practice of fracture repair there has remained a significant
McCartney, William T.
core   +2 more sources

Association of schizophrenia with fracture‐related femoral neck displacement: A cross‐sectional retrospective study

PCN Reports
Aim Fracture‐related femoral neck displacement is more likely in patients with schizophrenia because of delayed diagnosis, as these patients frequently have less severe fracture‐associated subjective symptoms.
Yukiyo Inoue, Akihiro Tokushige, Takeshi Kinjyo, Shinichiro Ueda   +3 more
doaj   +1 more source

Single Stage Hemiarthroplasty Bipolar Surgical Procedure in 1 year Neglected Femoral Neck Fracture with 4cm Limb Shortening: A Case Report

Orthopaedic Journal of Sports Medicine, 2020
The neglected femoral neck fractures in young adults have always presented a difficult problem with high rates of non-union and avascular necrosis. In developing countries many of these fractures present late, often as a result of delayed referral or ...
I Wayan Suryanto Dusak MD, I Dewa Gede Bracika Damma Prasada MD   +1 more
doaj   +1 more source

Femoral Shaft Fracture Associated with Ipsilateral Femoral Neck or Intertrochanteric Fracture

, 1995
The segmental fracture of the femur usually was caused by severe force and often accompanied with marked damage of the soft tissue and associated fractures of the other bones.
신규호
core   +1 more source

YAP1‐Driven Pathogenic Fibro‐Adipogenic Progenitors Secrete IL‐6 and FGF21 to Mediate Muscle‐Bone Crosstalk and Promote Bone Loss

Advanced Science, EarlyView.
Fibro‐adipogenic progenitors (FAPs) in atrophic muscle undergo YAP1‐driven pathogenic activation, secreting IL‐6 and FGF21 as bone‐catabolic myokines that mediate muscle‐bone crosstalk and promote bone loss. Genetic or pharmacological targeting of this YAP1‐FAP‐myokine axis rescues skeletal deterioration, identifying FAP‐derived myokines as therapeutic
Xiaoyu Cai, Tao Xu, Rui Ma, Weikun Meng, Shutao Gao, Yakefu Abulizi, Alafate Kahaer, Chuanhui Xun, Maierdan Maimaiti, Rui Cao, Weidong Liang, Polati Maimaiti, Qiang Deng, Jun Sheng, Ting Wang, Mingchong Liu, Weibin Sheng   +16 more
wiley   +1 more source

Trifocal femur fracture: Where should one begin? A case report and literature review

Trauma Case Reports
Introduction: Ipsilateral, non-contiguous femoral fractures involving the femoral neck, shaft, and distal articular region are extremely rare and typically result from high-energy trauma.
Gianluca Cera, Giovanni Longo, Michele Dell'Orfano, Daniele De Meo, Francesco Maria Milella, Roberta Pica, Filippo Laurenti   +6 more
doaj   +1 more source

Pseudoaneurysm of the proximal superficial femoral artery following blunt trauma in a footballer: A rare case report

Clinical Case Reports, 2022
Pseudoaneurysm of superficial femoral artery without any femoral fracture following blunt trauma is a rare clinical entity. Most cases of pseudoaneurysm of superficial femoral artery present to the hospital following penetrating injury, femoral fracture,
Krishna Gopal Shrestha, Amrit Pokhrel, Bikash Jang Kshetri, Sanjiv Bastakoti, Govinda Raj Pandey   +4 more
doaj   +1 more source

Gαi1/3 Are Essential for BMP2‐Induced Osteogenesis by Bridging BMP Receptors to the Gab1 Signaling Complex

Advanced Science, EarlyView.
The Gαi1/3 protein is a crucial connecting protein closely related to the signal transduction process of bone formation‐related cytokines such as BMP2. Gαi1/3 mediates downstream signaling pathways such as Smads and MAPK by binding to adaptor proteins like Gab1, thereby promoting the osteogenic effect of BMSCs.
Huajian Shan, Chaowen Bai, Yifei Zhu, Chenyang Xu, Sonngtao Li, Qize Sun, Chang She, Jinyu Bai, Cong Cao, Yitian Yang, Xiaozhong Zhou   +10 more
wiley   +1 more source

Traumatic anterior hip dislocation with associated bilateral femoral fractures in a child: a case report and review of the literature

The Pan African Medical Journal, 2019
Traumatic anterior hip dislocation is rare, because the hip joint is a highly stable joint. It is extremely rare for the anterior hip dislocation with combined bilateral femoral fracture in children.
Zongbing Cao, Dong Zhu, Chen Li, Yan-Hui Li, Lei Tan   +4 more
doaj   +1 more source