Results 111 to 120 of about 1,930,858 (393)

Osteonecrosis of the Femoral Head Caused by Bone Marrow Blockage: A Case Report

Journal of Orthopaedic Surgery, 2006
Interruption of the blood flow may occur in intraosseous arteries within the femoral head. We report a 72-year-old woman who developed osteonecrosis of the femoral head 11 months after surgery involving massive cementing of a segmental distal femoral ...
A Nishimura, M Hasegawa, A Sudo, A Uchida   +3 more
doaj   +1 more source

Morphological and Mechanical Evaluation of the Cancellous Bone in the Rat Femoral Head after Traumatic Osteonecrosis

Journal of Biomechanical Science and Engineering, 2006
Over 7000 patients are suffering from osteonecrosis of the femoral head annually in Japan. The patients have to undergo surgical treatments if the femoral head collapsed. The mechanism of femoral head collapse is still unclear, although morphological and
Go YAMAKO, Kunihiko TOKUNAGA, Reiko TAKANO, Naoto ENDO, Toshiaki HARA   +4 more
doaj   +1 more source

CDK4/6 Inhibition Induces CD8+ T Cell Antitumor Immunity via MIF‐Induced Functional Orchestration of Tumor‐Associated Macrophages

Advanced Science, EarlyView.
CDK4/6 inhibition promotes CD8+ T cell expansion through tumor‐macrophage crosstalk by activating HIF‐1α and enhancing MIF‐CD44/CD74 signaling. This reprograms TAMs to boost MHC‐I antigen presentation, and CDK4/6 inhibitor‐trained M1 TAM supernatant therapy synergizes with low‐dose PD‐1 blockade to restore antitumor immunity.
Lin He, Yuzhong Peng, Lat‐lun Leong, Jingbo Zhou, Dongyang Tang, Weilu Wang, Xiaoran Wu, Josh haipeng Lei, Yongqin Ye, Yangyang Feng, Yunfeng Qiao, Xiangpeng Chu, Di Mu, Qi Zhao, Tzuming Liu, Yan Chen, Paul Kwonghang Tam, Chu‐Xia Deng   +17 more
wiley   +1 more source

Nasal Mucosa‐Derived Extracellular Vesicles as a Systemic Antiaging Intervention

Advanced Science, EarlyView.
This study shows that nasal mucosa‐derived extracellular vesicles (nmEVs) exert systemic anti‐ageing effects in mice by restoring circadian rhythm, suppressing cellular senescence, and improving cognitive function. In aged human bone marrow mesenchymal stem cells, nmEVs reverse senescence‐associated phenotypes and reactivate core clock gene expression.
Wentao Shi, Lu Bian, Mengyuan Yu, Jun Wang, Mingzhu Gao, Liping Shen, Xiao Zhang, Zhiliang Huang, Hong Tang, Long Lv, Yunduan Que, Zengli Miao, Xuechao Wu, Qing Wang, Xiaojie Lu   +14 more
wiley   +1 more source

Fysaire dysplasie van de femurkop bij een jonge golden retriever [PDF]

, 2017
A one-year-old, male, neutered Golden retriever was presented with chronic progressive symptoms of pain and lameness of the hind limbs. Orthopedic examination revealed muscle atrophy of both hind limbs, severe pain reaction at passive extension of the ...
de Bakker, Evelien, Samoy, Yves, Stock, Emmelie, Van der Vekens, Elke, Van Hoof, Kristien   +4 more
core   +1 more source

Efficacy of umbilical cord-derived mesenchymal stem cell-based therapy for osteonecrosis of the femoral head: A three-year follow-up study

Molecular Medicine Reports, 2016
This is a retrospective analysis of the clinical effects of transplant of mesenchymal stem cells (MSCs) derived from human umbilical cord-derived MSCs (hUC-MSCs) for the treatment of osteonecrosis of the femoral head (ONFH).
Chun Chen, Zhiguo Qu, Xiaoguang Yin, Chunyu Shang, Q. Ao, Yongquan Gu, Y. Liu   +6 more
semanticscholar   +1 more source

A Rationally Engineered Spleen‐Tropic One‐Component Lipid‐mRNA Complex (OncoLRC) for Cancer Vaccines

Advanced Science, EarlyView.
OncoLRC, a one‐component lipid‐mRNA complex, enables efficient spleen‐targeted delivery at an exceptionally low lipid‐to‐mRNA mass ratio (1.5:1), robustly activates immune responses, inhibits tumor growth, and synergizes with checkpoint blockade, presenting a next‐generation platform for mRNA vaccines.
Qimeng Yin, Chenchen Zhang, Jiahao Li, Kun Huang, Min Qiu   +4 more
wiley   +1 more source

Metabolic Reprogramming Driven by Trophoblasts and Decidual XCR1+PMN‐MDSC Crosstalk Controls Adverse Outcomes Associated With Advanced Maternal Age

Advanced Science, EarlyView.
The interaction between trophoblasts and decidual polymorphonuclear myeloid‐derived suppressor cells (dPMN‐MDSCs) via the XCL1–XCR1 axis is crucial for fetal development during the third trimester. Disruption of this axis impairs FOXO1 activity and causes metabolic imbalance in dPMN‐MDSCs, contributing to adverse outcomes associated with advanced ...
Meiqi Chen, Yuxiong Guo, Qing Zhao, Jingping Liu, Shuyi Kuang, Zhengcong Huang, Chenlin Lv, Shuxiu Xu, Zekai Zhuang, Anyan Yang, Jing Li, Kai Wu, Yumei He   +12 more
wiley   +1 more source

Autologous concentrated bone marrow injection for precollapse osteonecrosis of the femoral head concurrent with contralateral total hip arthroplasty: protocol for a clinical trial

BMJ Open
Introduction The femoral head contralateral to the collapsed femoral head requiring total hip arthroplasty (THA) often manifests in the precollapse stage of osteonecrosis of the femoral head (ONFH).
Muneaki Ishijima, Ken Yamaji, Naoto Tamura, Naotake Yanagisawa, Hiroshi Ohtsu, Takuma Yamasaki, Yasuhiro Homma, Ken Tashiro, Yoshiki Okada, Yuichi Shirogane, Taiji Watari, Koju Hayashi, Tomonori Baba, Kazufumi Nagata, Naho Fujiwara, Jun Ando   +15 more
doaj   +1 more source

Extensive Recontouring of the Femoral Head with Osteochondral Allografting: A Case Report with Histological and MicroCT Analysis

Case Reports in Orthopedics, 2019
Morphological abnormalities such as cam deformity or growth disturbances can have a detrimental effect on the smooth function of the hip joint. This case reports an attempt to salvage the hip joint of a young patient with a posttraumatic growth ...
Amir A. Jamali, Douglas Rowland, Kristen N. Vandewalker   +2 more
doaj   +1 more source