Results 81 to 90 of about 106,955 (321)

Morphological and Mechanical Evaluation of the Cancellous Bone in the Rat Femoral Head after Traumatic Osteonecrosis

Journal of Biomechanical Science and Engineering, 2006
Over 7000 patients are suffering from osteonecrosis of the femoral head annually in Japan. The patients have to undergo surgical treatments if the femoral head collapsed. The mechanism of femoral head collapse is still unclear, although morphological and
Go YAMAKO, Kunihiko TOKUNAGA, Reiko TAKANO, Naoto ENDO, Toshiaki HARA   +4 more
doaj   +1 more source

The Cerebrospinal Fluid Secretion Rate Increases in Awake and Freely Moving Rats but Differs With Experimental Methodology

Advanced Science, EarlyView.
CSF dynamics are vital for neurological health. Yet accurate quantification of CSF rates is challenging. Using a novel technique in awake, freely moving rats, significantly higher secretion rates are found than in anesthetized rats. The findings highlight the importance of awake models and the adaptability of methods for studying CSF changes influenced
Trine L. Toft‐Bertelsen, Beatriche L. Edelbo, Annette B. Steffensen, Sara D. Lolansen, Jonathan H. Wardman, Dennis B. Jensen, Nanna MacAulay   +6 more
wiley   +1 more source

Construction of hybrid 1D‐0D networks for efficient and accurate blood flow simulations

International Journal for Numerical Methods in Fluids, Volume 95, Issue 2, Page 262-312, February 2023., 2023
A set of coupling equations to appropriately couple nonlinear 1D and lumped‐parameter (0D) models for blood flow in compliant vessels is defined. Then, a methodology for the high‐order numerical coupling between 1D and 0D vessels through hybrid junctions is proposed.
Beatrice Ghitti, Pablo J. Blanco, Eleuterio F. Toro, Lucas O. Müller   +3 more
wiley   +1 more source

A CLDN18.2‐Targeted Nanoplatform Manipulates Magnetic Hyperthermia Spatiotemporally for Synergistic Immunotherapy in Gastric Cancer

Advanced Science, EarlyView.
CLDN18.2 is a highly selective biomarker exposed in gastric cancer. A CLDN18.2‐specific antibody 1D5 conjugated fluorescence‐magnetic nanoparticle is developed for image‐guided precision theragnostics. Under the assistance of sensitive FMI and deep‐penetrating MPI for tracing and timing the optimal nanoparticle dosage, combining α‐PD1 therapy with ...
Xueying Wang, Hui Hui, Jing Han, Ting Guo, Yiding Wang, Lin Meng, Cong Chen, Jie He, Xiaoyong Guo, Fuyu Zhong, Hong Du, Jie Tian, Xiaofang Xing, Yang Du, Jiafu Ji   +14 more
wiley   +1 more source

Increasing the angle between caudal screw and the transverse plane may aggravate the risk of femoral head necrosis by deteriorating the fixation stability in patients with femoral neck fracture

European Journal of Medical Research
Necrosis of the femoral head is the main complication in femoral neck fracture patients with triangle cannulated screw fixation. Instant postoperative fixation instability is a main reason for the higher risk of femoral head necrosis.
Jian Zhang, Shengyu Wan, Xiaozhong Luo, Caidong Zhang, Chao Wu, Lipeng He, Jingchi Li   +6 more
doaj   +1 more source

Engineering the Immune Response to Biomaterials

Advanced Science, EarlyView.
This paper reviews immune responses to biomaterials, stages of evolution in relation to managing these responses ranging from preventing to modulating them. It also discusses state‐of‐the‐art strategies to modulate these responses and modes of their delivery.
Abolfazl Salehi Moghaddam, Mehran Bahrami, Einollah Sarikhani, Rumeysa Tutar, Yavuz Nuri Ertas, Faleh Tamimi, Ali Hedayatnia, Clotilde Jugie, Houman Savoji, Asma Talib Qureshi, Muhammad Rizwan, Chima V. Maduka, Nureddin Ashammakhi   +12 more
wiley   +1 more source

An objective analysis of composite free flap donor site morbidity in head and neck surgery: Prospective series

Head &Neck, Volume 45, Issue 2, Page 398-408, February 2023., 2023
Abstract Background A poor evidence basis exists regarding the objective donor site morbidity associated with osseous free flap harvest. This study prospectively assessed the objective donor site morbidity associated with osseous free flap harvest for the fibula, scapula, and iliac crest (DCIA) donor sites.
Joshua Russell, Glen Volker, Declan McGarvey, Catherine Sharpe, Omar Breik, Scott C. Borgna, Kelsey Pateman, Martin Batstone   +7 more
wiley   +1 more source

Extensive Recontouring of the Femoral Head with Osteochondral Allografting: A Case Report with Histological and MicroCT Analysis

Case Reports in Orthopedics, 2019
Morphological abnormalities such as cam deformity or growth disturbances can have a detrimental effect on the smooth function of the hip joint. This case reports an attempt to salvage the hip joint of a young patient with a posttraumatic growth ...
Amir A. Jamali, Douglas Rowland, Kristen N. Vandewalker   +2 more
doaj   +1 more source

Mannose‐Glycated Metal‐Phenolic Microcapsules Orchestrate Phenotype Switch of Macrophages for Boosting Tumor Immunotherapy

Advanced Science, EarlyView.
Immunomodulatory metal‐phenolic microcapsules (mMPMs) is developed in this study that leverages dopamine‐modified hyaluronic acid and FeIII assemble on mannose‐glycated bovine serum albumin microbubbles. mMPMs effectively promote macrophage internalization and M1 polarization, enhancing pro‐inflammatory responses.
Xin Tan, Renwang Sheng, Weikun Li, Yinghua Tao, Zonghao Liu, Ning Yang, Syeda Safia Hashmi, Feiling Feng, Fangzhou Liu, Liqin Ge   +9 more
wiley   +1 more source

Development of MDM2‐Targeting PROTAC for Advancing Bone Regeneration

Advanced Science, EarlyView.
This work presents a creative pipeline for developing MDM2‐targeting PROTACs (MDM2‐PROTACs) for application in bone regeneration. The developed PROTACs (CL144 and CL174) are validated for their degradation efficiency and osteogenic effects in human BMSCs.
Sol Jeong, Jae‐Kook Cha, Wasim Ahmed, Jaewan Kim, Minsup Kim, Kyung Tae Hong, Wonji Choi, Sunjoo Choi, Tae Hyeon Yoo, Hyun‑Ju An, Seung Chan An, Jaemin Lee, Jimin Choi, Sun‐Young Kim, Jun‐Seok Lee, Soonchul Lee, Junwon Choi, Jin Man Kim   +17 more
wiley   +1 more source