Results 181 to 190 of about 48,682 (293)

Beyond the Known and Established Neurodegenerative Effects: Roles of APOE Across a Wide Spectrum of Pathophysiological Condition

open access: yesMedComm, Volume 7, Issue 6, June 2026.
APOE is widely recognized for its role in neurodegeneration and cardiovascular disease, but its different genotypes also influence body composition, affecting obesity, bone density, and muscle mass, through their central role in lipid transport and metabolism.
Miriam Frosina   +5 more
wiley   +1 more source

Reduced‐Dose Dabrafenib–Trametinib for BRAF V600E–Mutant Lung Adenocarcinoma in a Very Elderly Patient With ECOG PS 2

open access: yesRespirology Case Reports, Volume 14, Issue 6, June 2026.
We describe a very elderly patient with ECOG performance status 2 who initially declined systemic therapy because of concerns about adverse events but later achieved symptom improvement and sustained disease control with reduced‐dose dabrafenib and trametinib.
Shun Suyama   +5 more
wiley   +1 more source

Guidelines for Essential Trauma Care: Second Edition (2026)

open access: yesWorld Journal of Surgery, Volume 50, Issue 6, Page 1409-1450, June 2026.
Injury is a major cause of death and disability globally, with the highest burden in low‐ and middle‐income countries (LMICs). Strengthening the organization and planning for trauma care (care of the injured) can improve care and lower mortality. In 2004, the International Association for Trauma Surgery and Intensive Care (IATSIC) and the World Health ...
Charles Mock   +41 more
wiley   +1 more source

Trends in femoral neck fracture-related mortality in the United States: A nationwide retrospective study from 1999 to 2023. [PDF]

open access: yesMedicine (Baltimore)
Faheem MSB   +6 more
europepmc   +1 more source

Developing and Designing an Evidence‐Informed Serratus Anterior Plane Block Education Program for Emergency Medicine

open access: yesEmergency Medicine Australasia, Volume 38, Issue 3, June 2026.
ABSTRACT Objective The aim of this paper is to describe the methods and processes used to develop a theory‐informed, dedicated serratus anterior plane block (SAPB) education and training program for Emergency Medicine clinicians. Methods This program was informed by Kern's six‐step approach to curriculum development.
Christopher Partyka   +4 more
wiley   +1 more source

Senescent BMSC‐Derived Thbs1 Drives Inflammaging and Impairs Bone Regeneration by Suppressing PINK1/Parkin‐Mediated Mitophagy in Macrophages

open access: yesAging Cell, Volume 25, Issue 6, June 2026.
Aging BMSC‐derived Thbs1 activates the macrophage TGF‐β/Smad3 pathway to transcriptionally repress Pink1, impairing mitophagy and causing mitochondrial ROS accumulation. This redox imbalance drives M1 polarization and IL‐6 secretion. IL‐6 feeds back to BMSCs via the JAK/STAT3 pathway to inhibit osteogenesis and upregulate Thbs1, establishing a self ...
Yifeng Xing   +15 more
wiley   +1 more source

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