Results 51 to 60 of about 77,750 (320)

Hyperviscous Diabetic Bone Marrow Niche Impairs BMSCs Osteogenesis via TRPV2‐Mediated Cytoskeletal‐Nuclear Mechanotransduction

Advanced Science, EarlyView.
Diabetic bone marrow exhibits pathological ECM hyperviscosity that activates TRPV2‐mediated Ca2⁺ influx, leading to perinuclear F‐actin disassembly, nuclear deformation, and chromatin condensation. This cytoskeletal‐nuclear decoupling suppresses osteogenic differentiation of BMSCs.
Yao Wen, Xinhui Zheng, Jieliu Li, Minyu He, Dongqi Fan, Xingyu Zhu, Qiming Zhai, Liangjing Xin, Tao Chen   +8 more
wiley   +1 more source

New technology: clinical efficacy of intracapsular decompression and supported hollow screw treatment for Garden IV femoral neck fractures

European Journal of Medical Research
Background The management of Garden IV femoral neck fractures presents a formidable challenge. This study aimed to assess the safety and efficacy of a novel technological approach for treating Garden IV femoral neck fractures, involving intracapsular ...
Zhaofeng Jia, Tinghui Xiao, Yimiao Lin, Wenjun Huang, Peizhi Deng, Jiandong Lin, Shiyuan Lin, Jiwu Cheng, Fengting Cui, Xinjia Hu, Xiaoming Zhang   +10 more
doaj   +1 more source

Failure after operative repair is higher for ballistic femoral neck fractures than for closed, blunt-injury fractures: a multicenter retrospective cohort study

Trauma Surgery & Acute Care Open
Introduction The purpose of this study was to describe the outcomes after operative repair of ballistic femoral neck fractures. To better highlight the devastating nature of these injuries, we compared a cohort of ballistic femoral neck fractures to a ...
Ranjan Gupta, Henry Tout Shu, Diane Ghanem, Davis L. Rogers, Oscar Covarrubias, Paul Izard, Jacques Hacquebord, Philip Lim, Greg M. Osgood, Babar Shafiq   +9 more
doaj   +1 more source

Ipsilateral Acetabular and Femoral Neck and Shaft Fractures

Case Reports in Orthopedics, 2015
Floating hip injuries and ipsilateral femoral neck and shaft fractures are rare. Additionally, the simultaneous occurrence of these injuries is extremely rare, and only one case report of the simultaneous occurrence of these injuries has been published ...
Hideto Irifune, Suguru Hirayama, Nobuyuki Takahashi, Eichi Narimatsu   +3 more
doaj   +1 more source

The relationship between adiposity, bone density and microarchitecture is maintained in young women irrespective of diabetes status [PDF]

, 2017
Background: The relationship between bone health and adiposity and how it may be affected in people with chronic metabolic conditions is complex. Methods: 17 women with Type 1 diabetes mellitus (T1DM) and 9 age-matched healthy women with a median ...
Abdalrahaman, N., Ahmed, S.F., Drummond, R., Foster, J.E., Lindsay, R.S., Mccomb, C., McKay, G.A., Perry, C.G.   +7 more
core   +1 more source

SLC2A3‐Mediated Lactate Metabolism Promotes Lung Cancer Bone Metastasis by Modulating P53 Lactylation and Immune Evasion

Advanced Science, EarlyView.
SLC2A3 derived lactate promotes metastasis through p53 lactylation at K120 and osteoclast differentiation. Pharmacological inhibition of SLC2A3 upregulates PD‐1 expression on CD8+ T cells via lactate induced p53 lactylation, which modulates immune evasion. ABSTRACT Bone metastasis is a devastating consequence of lung cancer.
Yi Ding, Yuying Tian, Wenjie Ren, Xianglin Hu, Mengjuan Li, Bei Liu, Chen chen, Yunhan Lu, Lei Li, Wangjun Yan, Kun Li   +10 more
wiley   +1 more source

Dual-energy computed tomography may reduce delayed diagnosis of occult hip fractures: Experiences at a single center

SAGE Open Medicine
Objectives: Early surgical intervention within 48 h is critical for reducing mortality and morbidity in patients with hip fractures. However, occult hip fractures are often missed, leading to treatment delays.
Hirotaka Kawakami, Hiromi Sasaki, Junichi Kamizono, Yuki Yasutake, Kana Yamada, Suguru Saho, Takehiro Kawauchi, Noboru Taniguchi   +7 more
doaj   +1 more source

Superior short-term outcomes of FNS in combination with a cannulated screw in treating femoral neck fractures

BMC Musculoskeletal Disorders, 2023
Background This study aimed to evaluate the clinical efficacy of the femoral neck system alone or in combination with a cannulated screw compared with other internal fixation methods for treating femoral neck fractures.
Min Su, Zexing He, Nianlai Huang, Xiaocong Lin, Kaibin Fang, Zhangsheng Dai   +5 more
doaj   +1 more source

Identification of a Force‐Induced Sox9+Acan+ Transitional Subpopulation Linked to FGF2–FGFR2–ERK Signaling in Orthodontic Bone Remodeling

Advanced Science, EarlyView.
Mechanical loading induces a previously unrecognized Sox9+Acan+ transitional mesenchymal cell population in the periodontal ligament that promotes osteoclastogenesis via the FGF2–FGFR2–ERK axis. Targeting this mechanoresponsive stromal population using a localized GelMA@siRNA delivery strategy attenuates pathological osteoclast overactivation and root ...
Miao Tan, Minyu He, Mingrui Zong, Qiya Tang, Yinan Liu, Jiaju Deng, Shun Huang, Xiaoxiao Lei, Jie Li, Lan Huang   +9 more
wiley   +1 more source

Dynamic compression locking system versus multiple cannulated compression screw for the treatment of femoral neck fractures: a comparative study

BMC Musculoskeletal Disorders, 2020
Background Femoral neck fractures are one of the problems in clinical treatment. The prognosis is uncertain. Currently, No internal fixation method is superior to other internal fixation methods in the treatment of femoral neck fractures.
Dong-Ping Shu, Ya-Ping Xiao, Ming-Jian Bei, Tao Ji, Yong-Jun Peng, Bing Ma, Shao-Gang Li   +6 more
doaj   +1 more source