Results 81 to 90 of about 83,212 (276)

A non-synonymous coding change in the CYP19A1 gene Arg264Cys (rs700519) does not affect circulating estradiol, bone structure or fracture [PDF]

, 2011
Background The biosynthesis of estrogens from androgens is catalyzed by aromatase P450 enzyme, coded by the CYP19A1 gene on chromosome 15q21.2. Genetic variation within the CYP19A1 gene sequence has been shown to alter the function of the enzyme.
Wang, J.Z., Deogan, M.S., Lewis, J.R., Chew, S., Mullin, B.H., McNab, T.J., Wilson, S.G., Ingley, E., Prince, R.L.   +8 more
core   +3 more sources

Postoperative Stress Accelerates Atherosclerosis Through Inflammatory Remodeling of the HDL Proteome and Impaired Reverse Cholesterol Transport

Advanced Science, EarlyView.
The study shows that noncardiac surgical inflammation rapidly disrupts HDL function and cholesterol efflux in mice and human patients. Impaired reverse cholesterol transport after surgery drives rapid lipid accumulation, NETosis, and apoptosis within atherosclerotic plaques.
Dominique M. Boucher, Victoria Lorant, Valerie Rochon, Abigail Carter, Cameron Stotts, My‐Anh Nguyen, Thomas Laval, Christina Emerton, Nathan Joyce, Nysa Vinayak, Marlena Scaffidi, David Cook, Katey J. Rayner, Rebecca C. Auer, Scott M. Gordon, Mireille I. Ouimet   +15 more
wiley   +1 more source

Candidate gene analysis of femoral neck trabecular and cortical volumetric bone mineral density in older men. [PDF]

, 2010
In contrast to conventional dual-energy X-ray absorptiometry, quantitative computed tomography separately measures trabecular and cortical volumetric bone mineral density (vBMD).
Barrett-Connor, Elizabeth, Cauley, Jane A, Ensrud, Kristine E, Ferrell, Robert E, Hoffman, Andrew R, Kammerer, Candace M, Klei, Lambertus, Lang, Thomas F, Lewis, Cora, Moffett, Susan P, Nestlerode, Cara S, Orwoll, Eric S, Osteoporotic Fractures in Men (MrOS) Study Group, Roeder, Kathryn, Yerges, Laura M, Zmuda, Joseph M   +15 more
core  

Observation of short-term curative effect of femoral neck system for femoral neck fracture in adults [PDF]

, 2022
Abstract Purpose The femoral neck system is a potentially effective implant for treating femoral neck fractures, However, there are few studies on the postoperative outcomes. This study aimed to evaluate short-term curative effect of FNS for femoral neck fracture in adults.
shoujin tian, jianfei ge, xiaolong lin, wei zhang, su liu, xiaolei sheng   +5 more
openaire   +1 more source

LMO7 Suppresses Tumor‐Associated Macrophage Phagocytosis of Tumor Cells Through Degradation of LRP1

Advanced Science, EarlyView.
LMO7 in tumor‐associated macrophages suppresses phagocytosis of tumor cells and limits cytotoxic T lymphocytes infiltration, fostering tumor progression. Mechanistically, LMO7 mediates the ubiquitination and degradation of the phagocytic receptor LRP1, impairing its ability to engulf tumor cells and driving macrophages toward an antitumor phenotype ...
Mengkai Li, Tao Wang, Yuwen Zhong, Zhiming Wang, Wei Li, Zejian Wang, Xinyi Yang, Yu Qiao, Jianfeng Xiang, Wei Gu, Zishu Wang, Lei Sun, Feng Qian   +12 more
wiley   +1 more source

Nonanatomical reduction of femoral neck fractures in young patients treated with femoral neck system: a retrospective cohort study

BMC Musculoskeletal Disorders, 2023
Purpose Negative buttress reduction should be avoided in the treatment of femoral neck fractures (FNFs) using conventional fixation. As the femoral neck system (FNS) has been recently developed and utilized widely to treat FNFs, the association of ...
Qilong Jiang, Yang Liu, Xinwen Bai, Yu Deng, Yong Cao, Chengxiang Yu, Qizhi Song, Yan Li   +7 more
doaj   +1 more source

Automated recognition and post-coordination of complex clinical terms [PDF]

, 2011
One of the key tasks in integrating guideline-based decision support systems with the electronic patient record is the mapping of clinical terms contained in both guidelines and patient notes to a common, controlled terminology.
Gooch, P., Roudsari, A.
core  

Psychiatric illness predicts poor outcome after surgery for hip fracture: a prospective cohort study [PDF]

, 2000
Background. Hip fracture is common in the elderly. Previous studies suggest that psychiatric illness is common and predicts poor outcome, but have methodological weaknesses. Further studies are required to address this important issue. Methods.
Holmes, J., House, A.
core   +1 more source

CDK4/6 Inhibition Induces CD8+ T Cell Antitumor Immunity via MIF‐Induced Functional Orchestration of Tumor‐Associated Macrophages

Advanced Science, EarlyView.
CDK4/6 inhibition promotes CD8+ T cell expansion through tumor‐macrophage crosstalk by activating HIF‐1α and enhancing MIF‐CD44/CD74 signaling. This reprograms TAMs to boost MHC‐I antigen presentation, and CDK4/6 inhibitor‐trained M1 TAM supernatant therapy synergizes with low‐dose PD‐1 blockade to restore antitumor immunity.
Lin He, Yuzhong Peng, Lat‐lun Leong, Jingbo Zhou, Dongyang Tang, Weilu Wang, Xiaoran Wu, Josh haipeng Lei, Yongqin Ye, Yangyang Feng, Yunfeng Qiao, Xiangpeng Chu, Di Mu, Qi Zhao, Tzuming Liu, Yan Chen, Paul Kwonghang Tam, Chu‐Xia Deng   +17 more
wiley   +1 more source

Comparison of the clinical efficacy of a femoral neck system versus cannulated screws in the treatment of femoral neck fracture in young adults

BMC Musculoskeletal Disorders, 2021
Background To compare the clinical efficacy of a femoral neck system (FNS) and cannulated screws (CS) in the treatment of femoral neck fracture in young adults.
Changjun He, Yao Lu, Qian Wang, Cheng Ren, Ming Li, Mingyi Yang, Yibo Xu, Zhong Li, Kun Zhang, Teng Ma   +9 more
doaj   +1 more source