Results 91 to 100 of about 83,212 (276)

Positioning novel biologicals in CKD-mineral and bone disorders [PDF]

, 2017
Renal osteodystrophy (ROD), the histologic bone lesions of chronic kidney disease (CKD), is now included in a wider syndrome with laboratory abnormalities of mineral metabolism and extra-skeletal calcifications or CKD-mineral and bone disorders (CKD-MBD),
Covic, Adrian, Mazzaferro, Sandro, Muci, MARIA LUISA, Pasquali, Marzia, Rotondi, Silverio, Tartaglione, Lida   +5 more
core   +1 more source

A Nanoparticle‐Integrated Complete Manufacturing Pipeline of Chemically Engineered Exosomes

Advanced Science, EarlyView.
We report a novel manufacture technology of chemically engineered exosomes. The four steps of manufacturing, i.e., biogenesis, loading, isolation, and storage, are integrated by the use of a nanoparticle. The manufacture technology incorporates three innovative components, i.e., a new nano‐bio effect, a new composite nanoparticle, and a new isolation ...
Xiaowei Wen, Zixing Xu, Zerun Hao, Yanming Chen, Kai Xie, Haofan Yin, Xueying Wang, Jie Min, Sihan Sun, Baiding Chen, Chengxiu Ling, Mingming Xu, Yizhao Chen, Gang Ruan   +13 more
wiley   +1 more source

Anti‐Shortening Screw for the Prevention of Postoperative Shortening in Displaced Femoral Neck Fractures: A Retrospective Cohort Study

Orthopaedic Surgery
Background Early femoral neck shortening after femoral neck system (FNS) fixation for displaced femoral neck fractures can occur in 22.3%–39.1% of cases, leading to decreased hip joint function.
Dongze Lin, Weipeng Gong, Chaohui Lin, Jiajie Liu, Ke Zheng, Peisheng Chen, Fengfei Lin   +6 more
doaj   +1 more source

A new species of Anadia (Reptilia, Squamata) from the Venezuelan 'Lost World', northern South America [PDF]

, 2011
A new gymnophthalmid lizard of the genus Anadia Gray, 1845 is described from the summit of Abakapá-tepui, Bolívar State, Venezuela, between 2200-2242 m elevation. The new species, Anadia mcdiarmidi sp.
Kok, Philippe J.R., Rivas, Gilson A.
core   +4 more sources

Single‐Cell Atlas of Subchondral Bone Marrow Lesions Reveals Proteostasis Dysfunction as a Druggable Mechanism for Early Osteoarthritis

Advanced Science, EarlyView.
This study reveals that abnormal mechanical stress downregulates the expression of HSP70 and impairs proteasome function in osteoarthritic bone cells, leading to misfolded collagen I accumulation and ER stress. When intracellular proteostasis capacity is exceeded, USP19 mediates the secretion of misfolded proteins into the extracellular space ...
Hailun Xu, Ting He, Yu Qian, Jia Li, Bowei Ni, Xiaojie Xu, Huanbo Wang, Peng Wang, Guoqing Cao, Siqi Ying, Guangyu Ding, Rong Wang, Zenghui Gu, Wei Li, Zhentao Man, Houfeng Zheng, Zhaohua Zhu, Zhen Li, Qingjun Meng, Chao Zheng, Liu Yang   +20 more
wiley   +1 more source

Comparative efficacy of different anti-shortening screws in preventing postoperative shortening in displaced femoral neck fractures: a retrospective cohort study

Journal of Orthopaedic Surgery and Research
Background Femoral neck fractures are common with high complication rates. Postoperative shortening is a significant issue, causing functional decline and increased avascular necrosis risk.
Fengfei Lin, Dongze Lin, Jiajie Liu, Ke Zheng, Chaohui Lin   +4 more
doaj   +1 more source

Cancellous bone and theropod dinosaur locomotion. Part I—an examination of cancellous bone architecture in the hindlimb bones of theropods [PDF]

, 2018
This paper is the first of a three-part series that investigates the architecture of cancellous (‘spongy’) bone in the main hindlimb bones of theropod dinosaurs, and uses cancellous bone architectural patterns to infer locomotor biomechanics in extinct ...
Aamodt, Abel, Adachi, Alexander, Alexander, Alexander, Alexander, Allen, Allen, Allmendinger, Amson, Andrada, Bakker, Bakker, Barak, Barak, Barthel, Batdorf, Batdorf, Bates, Beaupré, Beer, Bell, Ben-Zvi, Bennett, Benson, Bernsen, Bertram, Biewener, Biewener, Biewener, Biewener, Bishop, Bishop, Bishop, Bishop, Bishop, Blob, Blob, Blomberg, Bonnan, Boyle, Brassey, Brusatte, Butcher, Cardozo, Carlson, Carrano, Carrano, Carrano, Carrano, Carrano, Carrano, Carrano, Carrano, Carter, Carter, Chiappe, Chitale, Christen, Christiansen, Christiansen, Christiansen, Christiansen, Clarke, Clemente, Coelho, Coombs, Cowin, Cowin, Cowin, Cowin, Cracraft, Cresswell, Cruz-Orive, Cubo, Cunningham, Cunningham, Currey, Currey, Dacke, Davies, De Ricqlès, Demes, Demes, Demes, DeSilva, Donnell, Doube, Doube, Dunning, D’Anastasio, Elke, Enlow, Fariña, Farke, Farlow, Farlow, Farlow, Frost, Frost, Fyhrie, Garden, Gatesy, Gatesy, Gatesy, Gatesy, Gatesy, Gatesy, Gatesy, Gatesy, Gatesy, Gatesy, Gauthier, Gefen, Georgiou, Giddings, Gillette, Goldstein, Goldstein, Goodwin, Gorissen, Gosman, Gosman, Gross, Grossi, Hackett, Haddrath, Hammer, Harrigan, Havill, Hayes, Heers, Heinrich, Henderson, Heřt, Holtz, Hone, Horner, Horner, Hotton, Huiskes, Huiskes, Hutchinson, Hutchinson, Hutchinson, Hutchinson, Hutchinson, Hutchinson, Hutchinson, Hutchinson, Hutchinson, Hutchinson, Hébert, Hübner, Jacobs, Jacobs, Jang, Jang, Jang, Jarvis, Jetz, Judex, Kabel, Kambic, Kambic, Kamibayashi, Keaveny, Keaveny, Ketcham, Ketcham, Kivell, Koch, Koo, Kowalczyk, Ksepka, Ksepka, Lambers, Landini, Landini, Lane, Lanyon, Lanyon, Lanyon, Lee, Lee, Legendre, Lieberman, Lieberman, Lockley, Lovejoy, Macchiarelli, Maidment, Maidment, Maidment, Main, Main, Mallison, Mallison, Maquer, Martin, Matarazzo, Mazzetta, Middleton, Miller, Mitchell, Mittra, Molnar, Moreno, Morgan-Richards, Mullender, Murray, Nafei, Nafei, Naish, Novas, Odgaard, Odgaard, Odgaard, Ollion, Olmos, Ostrom, Owen, Oxnard, Parfitt, Paul, Paul, Paul, Pauwels, Pearson, Petterson, Phillips, Phillips, Phillips, Pidaparti, Pittman, Podsiadlo, Polk, Pontzer, Pontzer, Prum, Radin, Rafferty, Raichlen, Reid, Reilly, Robling, Robling, Rook, Rubenson, Rudman, Ruimerman, Russell, Ryan, Ryan, Ryan, Ryan, Ryan, Ryan, Ryan, Ryan, Saers, Saparin, Scherf, Scherf, Schulte, Schweitzer, Sereno, Shrout, Singh, Singh, Skedros, Skedros, Skedros, Skerry, Skinner, Smith, Smith, Smith, Stephens, Stoessel, Su, Su, Su, Sues, Sutherland, Sverdlova, Swartz, Takechi, Tanck, Thomas, Thomason, Thomason, Thompson, Thulborn, Thulborn, Tobin, Townsley, Townsley, Tsai, Tsai, Tsegai, Tsegai, Tsubota, Tsubota, Turner, Turner, Turner, Turner, Turner, Ulrich, Van der Meulen, Van der Reest, Van Rietbergen, Van Rietbergen, Vander Sloten, Verner, Volpato, Von Meyer, Wainwright, Wallace, Wallace, Wallace, Wang, Ward, Warton, Weingarten, Weishampel, Wellnhofer, Wilson, Winter, Wolff, Wolschrijn, Yang, Yuri, Zanno   +335 more
core   +3 more sources

Distinct Immunomodulatory Strategies Guide Mesenchymal Stromal/Stem Cell‐Mediated Bone Regeneration

Advanced Science, EarlyView.
Bone regeneration by mesenchymal stem cells is strongly influenced by immune signals. This study shows that priming stem cells with regulatory immune cells or an inflammation‐resolving lipid molecule enhances bone formation through distinct immune pathways.
Salwa Suliman, Carla Alvarez Rivas, Aashish Srivastava, Nora Marek, Kamal Mustafa, Alpdogan Kantarci   +5 more
wiley   +1 more source

Biomechanical effects of FNS on femoral neck fractures based on different reduction quality: finite element analysis

BMC Musculoskeletal Disorders
Background and objective The femoral neck system (FNS) has been extensively studied and applied for the treatment of young patients with femoral neck fractures.
Xu Zhang, Yazhong Zhang, Shaolong Huang, Xiangyu Qi, Wenbo Li, Yongxiang Lv, Ziqiang Zhu   +6 more
doaj   +1 more source

Context‐Dependent Role of GDF15: GDF15+ Tumor‐Associated Macrophages Suppress OSCC Progression by Enhancing Phagocytosis

Advanced Science, EarlyView.
This study identifies GDF15+ TAMs as a cell subset mediating tumor regression after immunotherapy. Macrophage‐intrinsic GDF15 enhances phagocytosis and antigen cross‐presentation to CD8+ T cells through the NF‐κB signaling pathway, thereby inhibiting tumor progression.
Xinyu Zhou, Zhihang Zhou, Houyu Ju, Chaoyang Guo, Fangxing Zhu, Yiyi Zhang, Xu Chen, Tongchao Zhao, Laiping Zhong, Jingzhou Hu   +9 more
wiley   +1 more source