Results 191 to 200 of about 476,865 (415)

Inter-laboratory replicability and sensitivity study of a finite element model to quantify human femur failure load: case of metastases [PDF]

open access: yesarXiv
Metastases increase the risk of fracture when affecting the femur. Consequently, clinicians need to know if the patients femur can withstand the stress of daily activities. The current tools used in clinics are not sufficiently precise. A new method, the CT-scan-based finite element analysis, gives good predictive results. However, none of the existing
arxiv  

Learning-Based Cost Functions for 3D and 4D Multi-Surface Multi-Object Segmentation of Knee MRI: Data from the Osteoarthritis Initiative

open access: yes, 2018
A fully automated knee MRI segmentation method to study osteoarthritis (OA) was developed using a novel hierarchical set of random forests (RF) classifiers to learn the appearance of cartilage regions and their boundaries.
Kashyap, Satyananda   +3 more
core   +1 more source

Iron Deficiency Impairs Dendritic Cell Development and Function, Compromising Host Anti‐Infection Capacity

open access: yesAdvanced Science, EarlyView.
Iron deficiency reduces monocyte dendritic cell progenitor (MDP) numbers by inhibiting migration and proliferation while promoting apoptosis, subsequently reducing downstream common dendritic cell precursors (CDP) and dendritic cell (DC). Impaired DCs enter the lungs via blood circulation, where reduced antigen presentation impairs T‐cell activation ...
Quanzhong Ren   +8 more
wiley   +1 more source

Artesunate Inhibits Neointimal Hyperplasia by Promoting IRF4 Associated Macrophage Polarization

open access: yesAdvanced Science, EarlyView.
This study shows that macrophage interferon regulatory factor 4 (IRF4) improved arterial injury‐induced neointimal hyperplasia by promoting of M2 polarization via up‐regulating krüppel‐like factor 4 (KLF4) in rodent and nonhuman primate models. Notably, artesunate is identified as a potent inducer of IRF4 in macrophages, and proposed as a promising ...
Jinlin Miao   +15 more
wiley   +1 more source

Wearable Systems of Reconfigurable Microneedle Electrode Array for Subcutaneous Multiplexed Recording of Myoelectric and Electrochemical Signals

open access: yesAdvanced Science, EarlyView.
A reconfigurable microneedle electrode array integrated system is developed for minimally invasive and transdermal monitoring of subcutaneous electromyography, reactive oxygen species, and pH values. By assembling discrete thumbtack‐shaped microneedles into an array, the system enables multi‐parameter detection with single‐microneedle resolution.
Zhengjie Liu   +12 more
wiley   +1 more source

The Effects of Locomotion-Induced Shock Loading on Tibiofemoral Bone Stress Response

open access: yes, 2016
Purpose/Hypothesis: Knee osteoarthritis (Coats, Zioupos, & Aspden) is a degenerative joint disease that negatively impacts the quality of life. About 9.3 million people in the U.S. population are affected.
Daun, Karen   +2 more
core  

Osteosarcoma Cell‐Derived Migrasomes Promote Macrophage M2 Polarization to Aggravate Osteosarcoma Proliferation and Metastasis

open access: yesAdvanced Science, EarlyView.
Migrasomes are newly discovered organelles in migrating cells. This study finds that osteosarcoma cell‐derived migrasomes promote the tumor‐promoting phenotype of macrophages and further aggravate osteosarcoma malignant progression via milk fat globule‐EGF factor 8.
Wanshun Liu   +10 more
wiley   +1 more source

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