Results 201 to 210 of about 489,827 (389)
These study underscores the pivotal role of neutrophil‐derived myeloid‐related protein 14 (MRP14) in the pathophysiology of acute ischemic stroke (AIS). MRP14 not only disrupts mitochondrial function, thereby inhibiting microglial phagocytosis of neutrophils, but also activates microglial pyroptosis, exacerbating neuroinflammation following AIS ...
Huijuan Jin+10 more
wiley +1 more source
Nailing in Situ of Slipped Proximal Epiphysis of the Femur [PDF]
E Severin
openalex +1 more source
USP8‐Governed MDA5 Homeostasis Promotes Innate Immunity and Autoimmunity
This study reveals that USP8 stabilizes MDA5 via AKT‐mediated phosphorylation (Ser718), enhancing their interaction and MDA5 deubiquitination. USP8 inactivation degrades MDA5, suppressing type I IFN and cytokine production. Pharmacological inhibition of USP8/AKT alleviates MDA5‐driven autoimmunity, demonstrating the USP8‐MDA5 axis as a therapeutic ...
Qimin Zhang+9 more
wiley +1 more source
Early diagnosis and treatment of low-grade myofibroblastic sarcoma in the left distal femur: a case report and literature review. [PDF]
Hu X+6 more
europepmc +1 more source
Fractures of Neck of Femur: Treatment and Results [PDF]
Ernest W Hey Groves
openalex +1 more source
This study develops a cartilage‐targeted DNA origami system (OCS) that protects and delivers si‐Stat3 to chondrocytes. OCS reduces MMP13 expression, enhances extracellular matrix stability, and lowers oxidative stress while improving cell survival. In vivo, OCS decreases cartilage degradation biomarkers and promotes tissue repair factors, demonstrating
Qi Lv+8 more
wiley +1 more source
Multiple osteofibrous dysplasia combined with femoral fracture with proximal femur shepherd's crook and femoral pseudojoint formation: case report and literature review. [PDF]
Wang Z, Qin S, Wang T, Wang J.
europepmc +1 more source
cmExoaCD11b induced the repolarization of immunosuppressive M2 macrophages into pro‐inflammatory M1 phenotype, thereby promoting the proliferation and activation of CD8+ T cells and reversing the immunosuppressive state of the tumor microenvironment.
Man Sun+14 more
wiley +1 more source