Results 81 to 90 of about 702,880 (318)

Macrophage‐Mediated Transport of Insoluble Indirubin Induces Hepatic Injury During Intestinal Inflammation

open access: yesAdvanced Science, EarlyView.
Plant‐derived bioactive molecules with low solubility and permeability induce hepatocyte injury, though the mechanisms driving their hepatic effects remain poorly understood. This study identifies a novel transport pathway in which poorly soluble indirubin accumulates in the liver via macrophage‐mediated uptake in Peyer's patches, exacerbating hepatic ...
Yiqi Xu   +9 more
wiley   +1 more source

Tuberculosis of the Neck of the Femur [PDF]

open access: yesActa Orthopaedica Scandinavica, 1930
(1930). Tuberculosis of the Neck of the Femur. Acta Orthopaedica Scandinavica: Vol. 1, No. 1-4, pp. 281-289.
openaire   +2 more sources

Bidirectional Interaction Between the Brain and Bone in Traumatic Brain Injury

open access: yesAdvanced Science, EarlyView.
Traumatic brain injury (TBI) disrupts the blood–brain barrier and activates neuroimmune responses, causing metabolic disturbances and long‐term bone mass loss. Concurrent fractures accelerate healing and enhance osteogenesis but disrupt regulatory mechanisms, leading to altered bone dynamics and exacerbating neuroinflammation, complicating recovery ...
Wei Zhang, Jun Zou, Lingli Zhang
wiley   +1 more source

Variation of Proximal Femoral Morphometry in Relation to Total Hip Replacement: A Study on Dry Femora

open access: yesPakistan Journal of Medical Research, 2021
Objective: Objective: Considerable variations exist in geometry of proximal femur across populations, which play an important role in total hip replacement surgeries. However, a rigorous characterization of femoral geometry across different geographical
Shabana Ali   +2 more
doaj   +2 more sources

"Neglected neck of femur fracture: Valgus intertrochanteric osteotomy, rigid internal fixation and cortical bone grafting": Forgotten but useful technique

open access: yesJournal of Orthopedics, Traumatology and Rehabilitation, 2014
Nonunion of fracture neck of femur is still a formidable surgical challenge. We hereby report a case of 23-year-old male who presented to us 6 years after trauma with a fracture neck of the femur with 7 cm shortening. In view of his young age, we treated
Mohan K Puttaswamy, Mukkanna Kudapalli
doaj   +1 more source

BCG‐Derived Outer Membrane Vesicles Induce TLR2‐Dependent Trained Immunity to Protect Against Polymicrobial Sepsis

open access: yesAdvanced Science, EarlyView.
B‐OMVs, nanoscale vesicles derived from BCG, are identified as effective and safe inducers of trained immunity that protect against sepsis. Through TLR2‐mediated metabolic and epigenetic reprogramming of hematopoietic stem cells, B‐OMVs enhance inflammatory response and phagocytic activity.
Yuan Gong   +16 more
wiley   +1 more source

Akkermansia Muciniphila Alleviates Severe Acute Pancreatitis via Amuc1409‐Ube2k‐Foxp3 Axis in Regulatory T Cells

open access: yesAdvanced Science, EarlyView.
Akkermansia depletion correlates with acute pancreatitis (AP) severity. A. muciniphila and its protein Amuc_1409 mitigate pancreatic/systemic inflammation by expanding Tregs and IL‐10. Mechanistically, Amuc_1409 binds Ube2k, inhibiting Foxp3 ubiquitination to stabilize Treg differentiation and IL‐10 production, countering SAP‐induced SIRS/CARS ...
Jinyan Xie   +9 more
wiley   +1 more source

Neck of Femur Fracture among Senior Citizen Managed with Hemiarthroplasty in a Tertiary Care Center in Nepal: An Observational Study

open access: yesJournal of Nepal Medical Association
Introduction: Hemiarthroplasty is recognized as a prominent therapeutic option for neck of femur fracture without preexisting acetabular  pathology; however, there are controversies in the scientific literature regarding this.
Bijay Poudel   +8 more
doaj   +1 more source

Theranostic Toolbox for Neutrophil Functionalization

open access: yesAdvanced Science, EarlyView.
Here, neutrophil‐specific fluorine nanoparticles additionally equipped with either activating or inhibiting peptides for a background‐free 19F MRI‐based nanotheranostic approach are engineered. It is demonstrated that this approach is suitable to visualize and concomitantly direct neutrophil functionality depending on the specific requirements to ...
Pascal Bouvain   +11 more
wiley   +1 more source

REGIONAL VARIATION OF MORPHOMETRIC MEASUREMENTS OF PROXIMAL END OF FEMUR IN COASTAL ANDHRA PRADESH AND ITS CLINICAL IMPLICATION TO IMPROVE SURGICAL OUTCOME

open access: yesNational Journal of Medical Research, 2017
Introduction: The neck of femur is an important modification in human being. The neck-shaft angle and different parameters of neck are clinically important to diagnose pathological conditions of the hip joint and also helpful in the treatment and follow-
Tapati Roy   +3 more
doaj  

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