Results 81 to 90 of about 93,738 (352)

LMO7 Suppresses Tumor‐Associated Macrophage Phagocytosis of Tumor Cells Through Degradation of LRP1

Advanced Science, EarlyView.
LMO7 in tumor‐associated macrophages suppresses phagocytosis of tumor cells and limits cytotoxic T lymphocytes infiltration, fostering tumor progression. Mechanistically, LMO7 mediates the ubiquitination and degradation of the phagocytic receptor LRP1, impairing its ability to engulf tumor cells and driving macrophages toward an antitumor phenotype ...
Mengkai Li, Tao Wang, Yuwen Zhong, Zhiming Wang, Wei Li, Zejian Wang, Xinyi Yang, Yu Qiao, Jianfeng Xiang, Wei Gu, Zishu Wang, Lei Sun, Feng Qian   +12 more
wiley   +1 more source

Variation of Proximal Femoral Morphometry in Relation to Total Hip Replacement: A Study on Dry Femora

Pakistan Journal of Medical Research, 2021
Objective: Objective: Considerable variations exist in geometry of proximal femur across populations, which play an important role in total hip replacement surgeries. However, a rigorous characterization of femoral geometry across different geographical
Shabana Ali, Sundus Ambreen, Khalil Ur Rehman   +2 more
doaj   +2 more sources

BONE DENSITY OF THE LUMBAR SPINE L1-L4 AND FEMUR NECK ON CHILDBEARING AGE WOMAN WHO ARE IMPLANT AND NON HORMONAL CONTRACEPTIVES ACCEPTORS.

Journal of Midwifery, 2018
mplant contraception is one type of contraceptive in the form of an implant made of silastik rubber containing the progestin hormone (levonogestrel) attached to the upper arm.
Kuswati Kuswati, Rohmi Handayani
doaj   +1 more source

Bone mechanical properties in healthy and diseased states [PDF]

, 2018
The mechanical properties of bone are fundamental to the ability of our skeletons to support movement and to provide protection to our vital organs.
Hussein, Amira I., Morgan, Elise F., Unnikrishnan, Ginu U.   +2 more
core   +1 more source

CDK4/6 Inhibition Induces CD8+ T Cell Antitumor Immunity via MIF‐Induced Functional Orchestration of Tumor‐Associated Macrophages

Advanced Science, EarlyView.
CDK4/6 inhibition promotes CD8+ T cell expansion through tumor‐macrophage crosstalk by activating HIF‐1α and enhancing MIF‐CD44/CD74 signaling. This reprograms TAMs to boost MHC‐I antigen presentation, and CDK4/6 inhibitor‐trained M1 TAM supernatant therapy synergizes with low‐dose PD‐1 blockade to restore antitumor immunity.
Lin He, Yuzhong Peng, Lat‐lun Leong, Jingbo Zhou, Dongyang Tang, Weilu Wang, Xiaoran Wu, Josh haipeng Lei, Yongqin Ye, Yangyang Feng, Yunfeng Qiao, Xiangpeng Chu, Di Mu, Qi Zhao, Tzuming Liu, Yan Chen, Paul Kwonghang Tam, Chu‐Xia Deng   +17 more
wiley   +1 more source

Increased associated risk of postoperative periprosthetic femur fracture with cementless versus cemented hemiarthroplasty: a nationwide database study of 24,419 femoral neck fractures

OTA International
. Objective:. We evaluated the associated risk of postoperative periprosthetic femur fracture after hemiarthroplasty for the treatment of femoral neck fracture based on stem fixation, cementless compared with cemented. Design:.
Frank Rodgers, MD, Zachary M. Working, MD, Darin Friess, MD, MPH, Jung Yoo, MD, Ryland Kagan, MD   +4 more
doaj   +1 more source

The Organization and Role During Locomotion of the Proximal Musculature of the Cricket Foreleg : I. Anatomy and Innervation [PDF]

, 1986
The structure of the proximal segments of the cricket (Gryllus bimaculatus) foreleg, together with the associated musculature and its innervation are described.
Laurent, Gilles, Richard, Daniel
core  

Development of a test system to analyze different hip fracture osteosyntheses under simulated walking [PDF]

, 2012
The mechanical complications of osteosyntheses after hip fractures are previously investigated by mostly static or dynamic uniaxial loading test systems.
Bachmeier, Samuel, Dendorfer, Sebastian, Füchtmeier, Bernd, Lenich, Andreas, Mayr, Edgar, Nerlich, Michael   +5 more
core   +1 more source

Microglial HVCN1 Deficiency Improves Movement and Survival of SOD1G93A ALS Mice by Enhancing Microglial Migration and Neuroprotection

Advanced Science, EarlyView.
Hydrogen voltage gated channel 1 (HVCN1) is upregulated in microglia of both ALS patients and its mouse model. HVCN1 deficiency enhances microglial migration via suppressing Akt signaling, promotes neurotrophic capacity and motor function, and prolongs survival of the SOD1G93A ALS mice. This study identifies HVCN1 as a novel, promising druggable target
Fan Wang, Ke‐Yu Zhang, Lang‐Jian Zhu, Wei‐Jue Li, Yang Wu, Xiang Gao, Xiao‐Ru Ma, Xiu‐Hua Yin, Jian‐Bin Wu, Xiao‐Kang Ye, Zhao‐Jun Dong, Di‐Xian Wang, Zhe Zhou, Shao‐Dong Wang, Lei Han, Zhi‐Nong Jiang, Jing‐Wei Zhao   +16 more
wiley   +1 more source

The Effect of Cement Placement on Augmentation of the Osteoporotic Proximal Femur

Geriatric Orthopaedic Surgery & Rehabilitation, 2010
Femoroplasty, the augmentation of the proximal femur, has been shown in biomechanical studies to increase the energy required to produce a fracture and therefore may reduce the risk of such injuries.
Edward G. Sutter MS, Simon J. Wall FRCS, Simon C. Mears MD, PhD, Stephen M. Belkoff PhD   +3 more
doaj   +1 more source