Results 131 to 140 of about 2,490 (179)

Pharmacokinetics of fenbendazole in dogs

Journal of Veterinary Pharmacology and Therapeutics, 1990
McKellar, Q.A., Harrison, P., Galbraith, E.A. & Inglis, H. Pharmacokinetics of fenbendazole in dogs. J. vet. Pharmacol. Therap. 13, 386–392.Fenbendazole was administered to dogs at a dose rate of 20 mg/kg body weight on a single occasion in gelatin capsules, on 5 consecutive days in feed, and on a single occasion as an alginate suspension.
Q A, McKellar, P, Harrison, E A, Galbraith, H, Inglis   +3 more
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Pharmacokinetics of Fenbendazole in Sheep

American Journal of Veterinary Research, 1981
SUMMARY Concentrations of fenbendazole and its sulfoxide, oxfendazole, and sulfone metabolites were determined in 6 sheep after oral administration of fenbendazole (10 mg/kg of body weight). Mean peak concentrations in plasma of fenbendazole, oxfendazole, and sulfone of 0.15, 0.29, and 0.17 μg/ml occurred 24, 30, and 36 hours after administration ...
S E, Marriner, J A, Bogan
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Disposition of fenbendazole in the goat

American Journal of Veterinary Research, 1987
SUMMARY The disposition of fenbendazole was studied in goats after oral or iv administration. Plasma concentration vs time profiles were determined for fenbendazole and all of its metabolites. The total excretion of the drug and its metabolites in urine and feces was also measured for 6 days.
C R, Short, S A, Barker, L C, Hsieh, S P, Ou, L E, Davis, G, Koritz, C A, Neff-Davis, R F, Bevill, I J, Munsiff, G C, Sharma   +9 more
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Disposition of fenbendazole in cattle

American Journal of Veterinary Research, 1987
SUMMARY Fenbendazole (fbz) was administered to cattle iv and orally in a crossover design. Plasma concentration vs time profiles were reported for fbz and its major metabolites, the sulfoxide (oxfendazole) and the sulfone. The total excretion of fbz and its metabolites in urine and feces was also measured for 6 days after administration.
C R, Short, S A, Barker, L C, Hsieh, S P, Ou, T, McDowell, L E, Davis, C A, Neff-Davis, G, Koritz, R F, Bevill, I J, Munsiff   +9 more
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Disposition of fenbendazole in the rabbit

Research in Veterinary Science, 1988
The disposition of fenbendazole was studied in rabbits following either oral or intravenous administration. The major metabolites appearing in plasma were fenbendazole sulphoxide (oxfendazole) and fenbendazole sulphone. Calculation of the total urinary and faecal elimination of the drug and of its known metabolites showed that only 40 per cent of the ...
C R, Short, S A, Barker, L C, Hsieh, S P, Ou, T, McDowell   +4 more
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Safety of fenbendazole in swine

American Journal of Veterinary Research, 1983
SUMMARY The safety of fenbendazole, an anthelmintic for use in swine, was tested by feeding 0, 25, 75, or 125 mg of fenbendazole/kg of body weight for 5 days. A dose-related transient leukopenia developed on day 7, but values returned to base line on day 15. In the groups fed 75 or 125 mg, sorbitol dehydrogenase activity increased on day 3 but returned
R H, Hayes, F W, Oehme, H, Leipold
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Uptake of Fenbendazole by Grazing Sheep with Access to Feed-Blocks Containing Fenbendazole

British Veterinary Journal, 1983
SUMMARY The concentrations of fenbendazole and oxfendazole, its principal metabolite, were measured in the plasma of sheep grazing marginal upland pasture with access to high-energy feed-blocks medicated with fenbendazole. Only one of 18 sheep appeared to consume an inadequate dose of fenbendazole.
J A, Bogan, S E, Marriner
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Evaluation of the safety of fenbendazole in cats

American Journal of Veterinary Research, 2000
Abstract Objective—To evaluate the safety of fenbendazole in domestic cats. Animals—28 six- to seven-month old domestic shorthair cats. Procedure—Cats were randomly assigned to 1 of 3 treatment groups or a control group (n = 7/group). Cats in the treatment groups were given fenbendazole at a dosage of 50, 150, or 250 mg/kg,
R D, Schwartz, A R, Donoghue, R B, Baggs, T, Clark, C, Partington   +4 more
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Efficacy of fenbendazole against tapeworms in calves

American Journal of Veterinary Research, 1983
SUMMARY Forty-five commercial-grade Angus calves naturally infected with tapeworms (Moniezia sp) were used in 2 controlled experiments to evaluate the cestocidal efficacy of 3 dosage levels of fenbendazole, methyl-5-(phenylthio) -2-benzimidazolecarbamate. In the 1st trial, 15 calves were divided into 3 groups of 5 each. One group served as nonmedicated
H, Ciordia, J A, Stuedemann, H C, McCampbell   +2 more
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Resistance of Cooperia curticei against fenbendazole

Research in Veterinary Science, 1986
Resistance of Cooperia curticei against fenbendazole was demonstrated in The Netherlands. Experimental infection of lambs followed by intraruminal injection of 5 mg kg-1 showed a 100 per cent survival of the C curticei population. With an in vitro egg development assay LC50 values between 0.23 and 0.38 micrograms ml-1 thiabendazole were found.
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