Results 51 to 60 of about 580 (130)
PathophysiologyMultiple sclerosis (MS) is a chronic, immune-mediated demyelinating disease of the central nervous system whose heterogeneous clinical, radiological, and biological course has long resisted precise individual-level prediction.
Alireza Minagar, Mohammadali Sahraian
doaj +1 more source
New Mechanisms and Therapeutic Targets in Systemic Lupus Erythematosus
MedComm, Volume 6, Issue 6, June 2025.Systemic lupus erythematosus (SLE) is a multiple organ involved autoimmune disorder with heterogeneous clinical manifestations. Despite hallmark features such as elevated type I interferon and the production of numerous autoantibodies, the underlying pathogenic mechanisms remain elusive.
Jingru Tian +4 more
wiley +1 more source
Bleeding by Bruton Tyrosine Kinase-Inhibitors: Dependency on Drug Type and Disease
, 2021 Bruton tyrosine kinase (Btk) is expressed in B-lymphocytes, myeloid cells and platelets, and Btk-inhibitors (BTKi) are used to treat patients with B-cell malignancies, developed against autoimmune diseases, have been proposed as novel antithrombotic ...
Philipp von Hundelshausen +1 more
core +1 more source
Oxidative Stress in Antigen Processing and Presentation
MedComm – Oncology, Volume 4, Issue 2, June 2025.Reactive oxygen species (ROS) play a crucial role in antigen processing and presentation, essential for linking innate and adaptive immunity. While balanced ROS levels promote immune function, excess ROS can disrupt antigen recognition, resulting in immune dysfunction.
Qinxia Chang +9 more
wiley +1 more source
Mediators of Inflammation, Volume 2025, Issue 1, 2025.Immune thrombocytopenia (ITP) is an autoimmune disorder characterized by a reduced platelet count, resulting in bleeding risks and compromised quality of life. Advances in understanding ITP pathogenesis have revealed critical roles for spleen tyrosine kinase (Syk) and Bruton’s tyrosine kinase (BTK) in Fc receptor (FcR)‐mediated immune pathways, which ...
Amirhossein Heidari +7 more
wiley +1 more source
Formulation, Optimization, and Evaluation of Fenebrutinib-Loaded Niosomal Gel for the Treatment of Rheumatoid Arthritis: A Novel Drug Delivery Approach [PDF]
Rheumatoid arthritis (RA) is a chronic autoimmune disorder characterized by persistent synovial inflammation, cartilage degradation, and systemic complications.
Satinder Kakar +2 more
core
New Therapeutic Approaches for Haemorrhagic Shock [PDF]
, 2022 Trauma is one of the leading causes of death and disability, affecting 6 million people annually worldwide. Haemorrhagic shock (HS), which causes hypoperfusion of organs and ischaemia, accounts for ~40% of trauma-associated deaths.
Patel, N
core +1 more source
Bruton's tyrosine kinase (BTK) mediates B cell receptor and Fc receptor signaling and is a key regulator of autoimmunity and allergy. A series of novel BTK inhibitors (BTKi) are currently in development for non-oncologic indications with covalent ...
Cenni, Bruno +2 more
core +1 more source