De la oncología a la neurología: terapias dirigidas con inhibidores de BTK y sus avances en esclerosis múltiple. [PDF]
La tirosina quinasa de Bruton (BTK) es una enzima esencial en la señalización de BCR y en la regulación de células inmunitarias, como microglía y linfocitos B.
Ortiz Couvet, Nerea
core
Recent advances in the development of anti-rheumatic drugs [PDF]
Introducere. Afecţiunile reumatice reprezintă un grup eterogen de maladii cronice pentru care tratamentul definitiv este necunoscut. Cu toate acestea, descoperirile recente în patogenia complexă a acestor maladii au deschis noi oportunităţi în elaborarea
Guriuc, Anastasia
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Targeting Bruton's Tyrosine Kinase (BTK) in Autoimmunity: Achievements, Opportunities and Challenges. [PDF]
Drug Des Devel TherTorke S, Dybowski S, Weber MS.
europepmc +1 more source
Involvement of Btk in Cardiovascular Disease and Its Therapeutic Targeting
Btk (Bruton's tyrosine kinase), a Tec-family kinase initially recognized for its role in B-cell signaling, has emerged as a critical player in thrombosis and cardiovascular disease.
Weber, Christian +5 more
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Comparison of variably specific Bruton tyrosine kinase inhibitors on platelet aggregation mediated by Fcγ receptor (FcγR) IIa, glycoprotein VI, and platelet endothelial aggregation receptor (PEAR) 1: implications for Bruton tyrosine kinase inhibitors as antithrombotic therapy. [PDF]
Res Pract Thromb HaemostKartika T +4 more
europepmc +1 more source
Bruton's Tyrosine Kinase Inhibitors in Multiple Sclerosis. [PDF]
DrugsLambe J, Fox RJ.
europepmc +1 more source
Population Pharmacokinetic Analysis of Fenebrutinib in Patients with Relapsing Multiple Sclerosis
Population Pharmacokinetic Analysis of Fenebrutinib in Patients with Relapsing Multiple SclerosisAnita Moein +5 more
openaire +1 more source
Correction to "Comprehensive Characterization of Bruton's Tyrosine Kinase Inhibitor Specificity, Potency, and Biological Effects: Insights into Covalent and Noncovalent Mechanistic Signatures". [PDF]
ACS Pharmacol Transl SciDarragh AC +5 more
europepmc +1 more source
Background Multiple sclerosis (MS) is an immune-mediated central nervous system disorder characterized by recurrent local neurological deficits and progressively accumulating neurodegenerative damage.
ZOU, YUANYUAN
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An Assessment of Kinase Selectivity, Enzyme Inhibition Kinetics and in Vitro Activity for Several Bruton Tyrosine Kinase (BTK) Inhibitors. [PDF]
ACS Pharmacol Transl SciCorrionero A +16 more
europepmc +1 more source