Results 81 to 90 of about 17,402 (231)

Aspects of zone-like identity and holotomographic tracking of human stem cell-derived liver sinusoidal endothelial cells

Frontiers in Cell and Developmental Biology
IntroductionLiver sinusoidal endothelial cells (LSEC) are specialized endothelial cells with unique metabolic and barrier functions adapted to the needs of the liver sinusoid.
Mikel Amirola-Martinez, Mikel Amirola-Martinez, Thomas Combriat, Thomas Combriat, Katharina Ferencevic, Ingrid Wilhelmsen, Ingrid Wilhelmsen, Andrea Dalmao-Fernandez, Andrea Dalmao-Fernandez, Petter Angell Olsen, Petter Angell Olsen, Justyna Stokowiec, Aleksandra Aizenshtadt, Aleksandra Aizenshtadt, Stefan Krauss, Stefan Krauss   +15 more
doaj   +1 more source

Gut microbiota dysbiosis in the inflammatory pathogenesis of diabetic retinopathy

VIEW, EarlyView.
This graphical abstract illustrates how gut dysbiosis drives diabetic retinopathy through the gut‐retina axis, a process unfolding in three interconnected stages. First, in the gut, a decrease in beneficial bacteria and an increase in pro‐inflammatory taxa compromise the intestinal barrier, causing a “leaky gut” that allows LPS to translocate into the ...
Junyan Hu, Jingxiang Zhong
wiley   +1 more source

Decreased Production of Tissue Plasminogen Activator in Endothelial Cells From Nasal Polyps

World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT Introduction Previous studies have demonstrated that chronic rhinosinusitis with nasal polyps (CRSwNP) is characterized by excessive fibrin deposition which is related to impaired production of tissue plasminogen activator(t‐PA) by epithelial cells.
Qian‐Qian Zhang, Chen Zhang, Jia‐Ni Chen, Fu‐Ying Cheng, Yi‐Zhang Wang, Shi‐Rui Xue, Huan Wang, De‐Hui Wang, Xi‐Cai Sun, Li Hu   +9 more
wiley   +1 more source

A New Model of Feeding Biomechanics Based on Tied‐Arch Principles

Integrative Zoology, EarlyView.
This new biomechanical model explains the major stress and strain patterns generated through the cranium during biting. The model proposes that the cranium resolves bite‐induced reaction forces through arcs of compressive stress that span the cranial structure between biting teeth and both jaw joints.
D. Rex Mitchell
wiley   +1 more source

From haemostasis to immunity: The expanding frontiers of platelet biology

British Journal of Haematology, EarlyView.
Platelets are versatile cells whose functions extend far beyond haemostasis and thrombosis, actively regulating innate and adaptive immunity, angiogenesis, lymphangiogenesis, liver regeneration, atherosclerosis and tumour metastasis. This demonstrates their central role in various physiological processes and multiple life‐threatening diseases ...
Xun Grace Wu, Nicole Tomei, Heyu Ni
wiley   +1 more source

Renal‐vascular axis: unmasking its role in vascular endothelial growth factor‐inhibitor vascular toxicity in cancer patients

British Journal of Pharmacology, EarlyView.
Abstract Vascular toxicity is a growing concern in cancer patients receiving vascular endothelial growth factor inhibitor (VEGFi) therapy, posing a significant threat to patient prognosis. While the primary mechanism of VEGFi‐induced vascular toxicity is linked to redox‐sensitive reactions that disrupt vascular tone, leading to hypertension and ...
Grace Whelan, Karla B. Neves
wiley   +1 more source

Therapeutic access points: The roles of circumventricular organs in drug delivery and metabolic regulation

British Journal of Pharmacology, EarlyView.
The current obesity drug landscape, dominated by GLP‐1 receptor agonists and emerging multi‐agonist therapies, has reinforced that long‐term weight loss is achieved in large part through central mechanisms that suppress appetite and reshape energy balance.
Ines Martinez‐Corral, Nicholas Monaco, Daniel I. Brierley, Monica Imbernon   +3 more
wiley   +1 more source

Shifting Concepts in Esthetic‐Zone Implant Therapy: Reflections From a 15‐Year Institutional Registry

Journal of Periodontal Research, EarlyView.
This registry‐based analysis provides a longitudinal overview of implant therapy within the maxillary esthetic zone over a 15‐year period. The data suggest three developments: (1) increasing integration of digital workflows through CAIS; (2) a cautious tendency toward earlier implant placement protocols; (3) a gradual reduction in simultaneous guided ...
Miha Pirc, Eugenia Settecase, Margherita Giorgia Liguori, Tobias Janson, Ronald Ernst Jung, Tim Joda   +5 more
wiley   +1 more source

Biologically‐Oriented Alveolar Ridge Preservation (BARP) in Intact and Compromised Extraction Sockets

Journal of Periodontal Research, EarlyView.
The Biologically‐oriented Alveolar Ridge Preservation (BARP) is an innovative technique characterized by the stratification of different biomaterials (collagen sponge and xenograft) at intact and compromised sockets. In both groups, the hard and soft tissue modification (bone width, bone height, tissue profile, and hard tissue composition) was limited.
Mattia Pramstraller, Roberto Farina, Anina Nives Zuercher, Ronald Ernst Jung, Mike Barbeck, Marco Fracasso, Alberto Sclip, Leonardo Trombelli   +7 more
wiley   +1 more source

Clinical practices in the management of cervical Hansen type I intervertebral disc herniation among veterinary neurologists in North America and Europe

Journal of Small Animal Practice, EarlyView.
Objectives To describe current clinical practices in the management of cervical Hansen type I intervertebral disc herniation among American College of Veterinary Internal Medicine/European College of Veterinary Neurology neurologists. Materials and Methods An anonymous web‐based survey was distributed via professional listservs between October and ...
A. Mondino, M. Riobó, N. J. Olby, S. Moore, P. J. Early   +4 more
wiley   +1 more source