Results 91 to 100 of about 9,926 (208)

Silent zone detection in asthma and its relation to T2 inflammation

Egyptian Journal of Chest Disease and Tuberculosis
Objective Study objectives are to detect small airways disease in asthma and to study T2 inflammatory markers (eosinophil count, IgE, phenotyping) in association with small airways disease.
Hala Samaha, Dalia Elhassan, Afnan Tayeb
doaj   +1 more source

Treatable Traits‐Oriented Management in Pre‐COPD With Severe Obstructive Sleep Apnea: A Case Report of Symptomatic and Spirometric Improvement After Integrated Therapy

Respirology Case Reports, Volume 14, Issue 8, August 2026.
This case illustrates a multifactorial treatable traits‐oriented approach in pre‐COPD complicated by severe obstructive sleep apnea. Inhaled triple therapy plus effective CPAP was associated with symptomatic and spirometric improvement over 12 weeks, although causality cannot be inferred from a single case.
Norifumi Kudeken
wiley   +1 more source

Switching from multiple-inhaler triple therapy to single, extra fine-inhaler triple therapy in severe refractory asthma with EGPA: beyond control. Case report and review of the literature

Drugs in Context
Eosinophilic granulomatosis with polyangiitis is a rare systemic vasculitis associated with asthma, eosinophilia and multi-organ involvement. This case report describes a 69-year-old male with severe, poorly controlled asthma who was diagnosed with ...
Francesco Menzella, Marcello Cottini, Silvia Tonin, Lorenzo Corsi, Annamaria Bosi, Andrea Ballarin, Ariel Floriani, Cristina Dartora, Matteo Tacconi, Carlo Lombardi   +9 more
doaj   +1 more source

Endotype Classification of Nonsteroidal Anti‐Inflammatory Drug‐Exacerbated Respiratory Disease According to Chronic Rhinosinusitis Comorbidity

Clinical &Experimental Allergy, EarlyView.
Soyoon Sim, Jieun Seo, Junhyuk Chang, Yoo Seob Shin, Rae Woong Park, Hae‐Sim Park   +5 more
wiley   +1 more source

Dissociated Biologic Responses Across the United Airway: A Case Report of Severe Asthma With Chronic Rhinosinusitis With Nasal Polyps and Eosinophilic Otitis Media

Respirology Case Reports, Volume 14, Issue 8, August 2026.
We report a case of severe asthma with chronic rhinosinusitis with nasal polyps and eosinophilic otitis media that was successfully controlled by switching biologic therapy from dupilumab to mepolizumab. Careful monitoring of disease activity and consideration of biologic switching may help achieve optimal control with currently available biologics ...
Tomoko Tajiri, Naoki Takemoto, Toshiya Minakata, Motohiko Suzuki, Yoshiyuki Ozawa, Hirotsugu Ohkubo   +5 more
wiley   +1 more source

Tezepelumab for early-onset severe allergic asthma with persistent airflow limitation and small airway dysfunction: a treatable traits approach

Drugs in Context
We report the case of an 18-year-old woman with early-onset severe allergic asthma and no other type 2 biomarkers except the presence of IgE, complicated by persistent airflow limitation, air trapping and forced oscillation technique-defined small airway
Francesco Menzella, Claudio Sorino, Carlo Lombardi, Annamaria Bosi, Silvia Tonin, Lorenzo Corsi, Andrea Ballarin, Marcello Cottini   +7 more
doaj   +1 more source

Inhaled N‐Acetylcysteine as a Potential Adjunctive Therapy in Mucus Plug‐Forming Asthma With Irpex lacteus Isolation: A Case Report

Respirology Case Reports, Volume 14, Issue 8, August 2026.
A 68‐year‐old woman with mucus plug‐forming asthma and highly tenacious sputum received repeated administrations of inhaled N‐acetylcysteine, with subsequent rapid sputum improvement and radiographic resolution of mucus plugging. This case suggests that tenacious sputum may represent a treatable trait and that inhaled N‐acetylcysteine may serve as a ...
Yuka Uchida, Yusuke Hirao, Koji Kurokawa, Yukari Ichikawa, Shiho Furusho, Haruhiko Ogawa   +5 more
wiley   +1 more source

Refining mild asthma phenotyping with FeNO: a population-based evaluation

npj Primary Care Respiratory Medicine
The utility of fractional exhaled nitric oxide (FeNO) was evaluated alongside blood eosinophils in phenotyping mild asthma. Inclusion of FeNO improved classification accuracy and calibration in an adapted ISAR-based model; however, its predictive improvement was modest and its susceptibility to transient elevations suggests limited added value for ...
Lim, Charmaine J. M., Breyer, Marie-Kathrin, Wouters, Emiel F. M., Breyer-Kohansal, Robab   +3 more
openaire   +2 more sources

Microenvironment‐Responsive Drug Delivery Systems for Ocular Surface Diseases: Mechanisms, Applications, and Translational Challenges

Small Science, Volume 6, Issue 8, August 2026.
Microenvironment‐responsive drug delivery systems overcome ocular physiological barriers by responding to temperature, pH, ions, reactive oxygen species, and enzymes. This review bridges material design, performance evaluation, and clinical translation, offering actionable insights for treating dry eye disease, infectious keratitis, and corneal ...
Jiamin Liu, Liangbo Chen, Yao Fu, Siyi Zhang   +3 more
wiley   +1 more source

Influência do grupo genético e da alimentação sobre o desempenho de cordeiros em confinamento

Pesquisa Agropecuária Brasileira, 2003
O objetivo deste trabalho foi estabelecer a influência do reprodutor e da alimentação sobre o desempenho de cordeiros em confinamento. O delineamento experimental foi o inteiramente casualizado, com arranjo fatorial 2x4, costituído de dois grupos ...
Barros Nelson Nogueira, Vasconcelos Vânia Rodrigues de, Araújo Marcelo Renato Alves de, Martins Espedito Cezário   +3 more
doaj