Results 131 to 140 of about 188,238 (387)

Ultra-High-Performance Liquid Chromatography-Tandem Mass Spectrometry Assay for Quantifying Fentanyl and 22 Analogs and Metabolites in Whole Blood, Urine, and Hair

Frontiers in Chemistry, 2019
Recently, synthetic opioid-related overdose fatalities, led by illicitly manufactured fentanyl and analogs, increased at an alarming rate, posing a global public health threat.
F. Busardò, J. Carlier, R. Giorgetti, A. Tagliabracci, R. Pacifici, M. Gottardi, S. Pichini   +6 more
semanticscholar   +1 more source

Novel Vaccine That Blunts Fentanyl Effects and Sequesters Ultrapotent Fentanyl Analogues

Molecular Pharmaceutics, 2020
Active immunization is an emerging potential modality to combat fatal overdose amid the opioid epidemic. In this study, we described the design, synthesis, formulation, and animal testing of an efficacious vaccine against fentanyl.
Rodell C. Barrientos, E. Bow, C. Whalen, Oscar B. Torres, A. Sulima, Z. Beck, A. Jacobson, K. Rice, G. Matyas   +8 more
semanticscholar   +1 more source

Fentanyl self-testing outside supervised injection settings to prevent opioid overdose: Do we know enough to promote it? [PDF]

, 2018
Since 2013, North America has experienced a sharp increase in unintentional fatal overdoses: fentanyl, and its analogues, are believed to be primarily responsible.
Australian Injecting & Illicit Drug Users League, Catherine R. McGowan, Centers for Disease Control and Prevention, Ciccarone, Ciccarone, Ciccarone, Clark, Compton, Cressman, Daniulaityte, European Monitoring Centre for Drugs and Drug Addiction, Fairbairn, Frank, Friedman, Gladden, Harris, Human Rights Watch, Johns Hopkins Bloomberg School of Public Health, Jozaghi, Lucy Platt, Lysyshyn, Magdalena Harris, Marshall, Massey, McGowan, Messac, Mounteney, Murray, Neira-Leon, O'Donnell, Quest, Rhodes, Rhodes, Rhodes, Rhodes, Schneider, Seth, Shaheen, Socias, Stewart, The Vancouver Sun, Tim Rhodes, United Nations Office on Drugs and Crime, United States Drug Enforcement Administration, United States Drug Enforcement Administration, Vivian Hope, Winstock   +46 more
core   +2 more sources

Infant Death due to Cannabis Ingestion

Drug Testing and Analysis, EarlyView.
ABSTRACT A child died in the emergency room of a local hospital a few hours after ingesting a substance the color of cork and the consistency of earth. At home, a modest amount of resinous substance was found. At the hospital, the child exhibited alterations in walking, balance, and consciousness.
Donata Favretto, Antonello Cirnelli, Roberto Pertile, Raffaella Stimamiglio, Clara Cestonaro, Oriana Cuman, Anna Pagliaro, Fabio Mattiazzi, Cristina Basso, Maddalena Galeazzi   +9 more
wiley   +1 more source

A comparative study of intravenous fentanyl, oral pregabalin, and a combination of both for attenuation of hemodynamic response to laryngoscopy and tracheal intubation

MRIMS Journal of Health Sciences
Background Responses due to laryngoscopy and endotracheal intubation have an effect on blood pressure, heart rate, catecholamines, and oxygen demand of myocardium. These transient changes may affect those with known cardiovascular disease.
Sarayu Ramamurthy, Guruprasad Bettaswamy
doaj   +1 more source

Harm reduction measures employed by people using opioids with suspected fentanyl exposure in Boston, Baltimore, and Providence

Harm Reduction Journal, 2019
BackgroundExposure to potent synthetic opioids such as illicitly manufactured fentanyl (IMF) has fueled the escalating overdose crisis in the USA, particularly in the east coast.
Saba Rouhani, J. Park, Kenneth B Morales, Traci C. Green, S. Sherman   +4 more
semanticscholar   +1 more source

Therapeutic and Prophylactic Vaccines to Counteract Fentanyl Use Disorders and Toxicity.

Journal of Medicinal Chemistry, 2020
The incidence of fatal overdoses has increased worldwide due to the widespread access to illicit fentanyl and its potent analogues. Vaccines offer a promising strategy to reduce the prevalence of opioid use disorders (OUDs) and to prevent toxicity from ...
Christine Robinson, Valeria Gradinati, F. Hamid, C. Baehr, B. Crouse, Saadyah E. Averick, M. Kovaliov, D. Harris, S. Runyon, F. Baruffaldi, M. Lesage, S. Comer, Marco Pravetoni   +12 more
semanticscholar   +1 more source

Opioids Delay Healing of Spinal Fusion: A Rabbit Posterolateral Lumbar Fusion Model [PDF]

, 2018
Background Context Opioid use is prevalent in the management of pre- and postoperative pain in patients undergoing spinal fusion. There is evidence that opioids downregulate osteoblasts in vitro, and a previous study found that morphine delays the ...
Briley, Karen C., Himed, Khaled, Jain, Nikhil, Khan, Safdar N., Phillips, Frank M., Toth, Jeffrey M.   +5 more
core   +1 more source

Identification of the Novel Synthetic Opioid N‐Pyrrolidino Isotonitazene at an Australian Drug Checking Service

Drug Testing and Analysis, EarlyView.
Close collaboration between an Australian drug checking service and an affiliated university laboratory identifies and characterises the novel synthetic opioid N‐pyrrolidino isotonitazene in an expected oxycodone sample presented by a member of the public.
Blake Curtis, Douglas J. Lawes, David Caldicott, Malcolm D. McLeod   +3 more
wiley   +1 more source

High willingness to use rapid fentanyl test strips among young adults who use drugs

Harm Reduction Journal, 2018
BackgroundSynthetic opioid overdose mortality among young adults has risen more than 300% in the USA since 2013, primarily due to the contamination of heroin and other drugs with illicitly manufactured fentanyl.
Maxwell S Krieger, Jesse L. Yedinak, J. Buxton, Mark Lysyshyn, E. Bernstein, J. Rich, Traci C. Green, Scott E. Hadland, B. Marshall   +8 more
semanticscholar   +1 more source