Results 141 to 150 of about 188,238 (387)

Translational Modeling as a Tool to Evaluate the Effectiveness of Nalmefene in a Community Setting: A Critical Perspective

open access: yes
Clinical Pharmacology &Therapeutics, EarlyView.
Celine M. Laffont   +2 more
wiley   +1 more source

Impaired Volume Regulation and Electrophysiology of Astrocytes In Situ in a Mouse Model for Megalencephalic Leukoencephalopathy With Subcortical Cysts

open access: yesGlia, EarlyView.
Cell culture studies show disrupted astrocyte physiology in the leukodystrophy MLC. Are intact astrocytes similarly affected? This study on astrocytes in MLC mouse brain slices confirms and extends in vitro studies on altered astrocyte physiology. ABSTRACT Electrical signaling, driven by ion fluxes between intra‐ and extracellular compartments, is ...
Sven Kerst   +5 more
wiley   +1 more source

Molecular dynamics of fentanyl bound to μ-opioid receptor

open access: yesJournal of Molecular Modeling, 2019
The molecular dynamics simulations of fentanyl complexed with the μ-opioid receptor (μOR) were studied using both inactive 4DKL and active 5C1M opioid receptor crystal structures.
Piotr F. J. Lipiński   +3 more
semanticscholar   +1 more source

Market Analysis of Synthetic Drugs: Amphetamine-type Stimulants, New Psychoactive Substances [PDF]

open access: yes, 2017
An estimated quarter of a billion people, or around 5 per cent of the global adult population, used drugs at least once in 2015. Even more worrisome is the fact that about 29.5 million of those drug users, or 0.6 per cent of the global adult population ...

core  

Analysis of Fentanyl and 18 Novel Fentanyl Analogs and Metabolites by LC-MS-MS, and report of Fatalities Associated with Methoxyacetylfentanyl and Cyclopropylfentanyl.

open access: yesJournal of Analytical Toxicology, 2018
Methoxyacetylfentanyl and cyclopropylfentanyl are two of the newest illicit opioids that are infiltrating the heroin market. Methoxyacetylfentanyl and cyclopropylfentanyl were reported by the Drug Enforcement Administration (DEA) in their third quarter ...
Melissa F. Fogarty   +2 more
semanticscholar   +1 more source

COMPARISON OF EPIDURAL AND INTRAVENOUS FENTANYL PATIENT-CONTROLLED ANALGESIA AFTER CESAREAN SECTION UNDER EPIDURAL ANESTHESIA WITH CHLOROPROCAINE [PDF]

open access: yes, 1997
This study compared two methods of postcesarean fentanyl patient- controlled analgesia (PCA). Fentanyl was administered intravenously (PCAI) or epidurally (PCAE) following cesarean section under epidural chloroprocaine anesthesia. Twenty-one ASA I and II
Larsen, Kim M.
core   +1 more source

The challenge of perioperative pain management in opioid-tolerant patients [PDF]

open access: yes, 2017
The increasing number of opioid users among chronic pain patients, and opioid abusers among the general population, makes perioperative pain management challenging for health care professionals.
Bifulco, F   +9 more
core   +2 more sources

Research progress on the depth of anesthesia monitoring based on the electroencephalogram

open access: yesIbrain, Volume 11, Issue 1, Page 32-43, Spring 2025.
Electroencephalogram (EEG) can noninvasive, continuous, and real‐time monitor the state of brain electrical activity, and the monitoring of EEG can reflect changes in the depth of anesthesia (DOA). The development of artificial intelligence can enable anesthesiologists to extract, analyze, and quantify DOA from complex EEG data.
Xiaolan He, Tingting Li, Xiao Wang
wiley   +1 more source

Neuroinflammation and Neurometabolomic Profiling in Fentanyl Overdose Mouse Model Treated with Novel β-Lactam, MC-100093, and Ceftriaxone

open access: yesToxics
Opioid-related deaths are attributed to overdoses, and fentanyl overdose has been on the rise in many parts of the world, including the USA. Glutamate transporter 1 (GLT-1) has been identified as a therapeutic target in several preclinical models of ...
Mohammed S. Alasmari   +12 more
doaj   +1 more source

Postoperative pain after MiniLap percutaneous versus standard laparoscopic salpingo‐oophorectomy: A propensity‐matched study

open access: yesInternational Journal of Gynecology &Obstetrics, EarlyView.
Abstract Objective The aim of this study was to compare postoperative outcomes in patients undergoing standard laparoscopic salpingo‐oophorectomy versus those using the MiniLap percutaneous surgical system, aiming to demonstrate the non‐inferiority of this ultra‐minimally invasive surgical technique compared to the current gold standard.
Stefano Restaino   +17 more
wiley   +1 more source

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