Results 161 to 170 of about 94,542 (298)

Toxicokinetic modelling of the synthetic cannabinoid 5F‐MDMB‐P7AICA and its main metabolite in pigs following pulmonary administration

British Journal of Clinical Pharmacology, EarlyView.
Aims Since their emergence on the drug market, synthetic cannabinoids (SC) are still gaining increasing importance in forensic toxicology. The representatives of the so‐called new psychoactive substances have in common that they have not undergone preclinical safety studies. Hence, knowledge on toxicokinetic (TK) data is sparse.
Adrian A. Doerr, Christiane Dings, Omar Zaher, Frederike Nordmeier, Nadja Walle, Matthias W. Laschke, Michael D. Menger, Peter H. Schmidt, Markus R. Meyer, Thorsten Lehr, Nadine Schaefer   +10 more
wiley   +1 more source

Cancer pain: current practice and emerging targets

British Journal of Pharmacology, EarlyView.
Cancer pain (CP) arises from a complex interplay between the tumour and its microenvironment. Many patients experience a mixed pain phenotype that encompasses nociceptive, neuropathic and neuroinflammatory mechanisms, and vary across tumour type and disease stage. Despite decades of intensive research, the mainstay of cancer pain treatment is still non‐
Yi Ye, Marcin Chwistek, Zhiting Gong, Vanessa Uzonwanne, Xiaojie Shi, Arpad Szallasi   +5 more
wiley   +1 more source

Fentanyl Detection in Biological Samples From Individuals Reporting Synthetic Cannabinoid Use in São Paulo, Brazil. [PDF]

Drug Alcohol Rev
Endo LG, de Oliveira RA, Miziara ID, Yonamine M, Castaldelli-Maia JM, Leyton V, Bombana HS.   +6 more
europepmc   +1 more source

Effects of fentanyl on pain and motor behaviors following a collagenase-induced intracerebral hemorrhage in rats

, 2016
Laurence Saine,1 Pierre Hélie,2 Pascal Vachon1 1Department of Veterinary Biomedicine, Faculty of Veterinary Medicine, 2Department of Pathology and Microbiology, Faculty of Veterinary Medicine, University of Montreal, Saint-Hyacinthe, Quebec ...
Vachon P, Saine L, Hélie P
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In silico prediction of novel effective combinational treatment of chronic pain in individual patients: A joint white paper of the H2020 QSPainRelief consortium

British Journal of Pharmacology, EarlyView.
Abstract Opioids are prescribed widely for chronic pain despite well‐recognised risks and variable long‐term benefit, reflecting the lack of effective alternatives for many patients. Combination therapies offer a promising strategy to enhance efficacy whilst reducing side effects.
André Mouraux, Solenn Gousset, Beltrán Alvarez, Monica Baiula, Wouter Bakker, Andrea Bedini, Monir Bertayli, Divakar Budda, Robert Carr, Elisabetta Cuna, Óscar Díaz, Nina Donner, Jesús Giraldo, Geert‐Jan Groeneveld, Berfin Gülave, David Guydan, Hemme Hijma, Rafael Maldonado, Pedro Renault, Carlos Rinaudo, Jeroen Elaissaiss‐Schaap, Athan Spiros, Sara Stoeber, Petri Takkala, Daan van Valkengoed, Coen van Hasselt, Elizabeth (Liesbeth) CM de Lange   +26 more
wiley   +1 more source

The c‐Src inhibitor eCF506 diminishes opioid tolerance and reduces β‐arrestin2 recruitment

British Journal of Pharmacology, EarlyView.
Morphine activation of μ receptors causes tolerance through c‐Src activation and β‐arrestin2 recruitment. c‐Src inhibition or degradation reduces β‐arrestin2 recruitment, μ receptor endocytosis, while causing receptor upregulation, all likely contributing to reduced morphine tolerance.
Samuel Singleton, Fraser Nunn, Erika Lace, Álvaro Lorente‐Macías, Rachel Toth, Asier Unciti‐Broceta, Tim G. Hales   +6 more
wiley   +1 more source

Fentanyl Exposure Is Associated with Adverse Respiratory Outcomes in Ventilated Preterm Neonates: A Retrospective Matched Cohort Study. [PDF]

J Clin Med
Di Chiara M, Laccetta G, De Nardo MC, Dito L, Terrin G.   +4 more
europepmc   +1 more source

Effect of Membrane Perforations With and Without Collagen Membrane Coverage in Vertical Ridge Augmentation: An Experimental Pilot In Vivo Study

Clinical Oral Implants Research, EarlyView.
ABSTRACT Objectives Given the proposed bioactive role of collagen membranes, we aimed to evaluate whether the perforation size of titanium‐reinforced dPTFE membranes, with or without an additional collagen membrane, influences outcomes of vertical alveolar ridge augmentation (VARA).
Istvan A. Urban, Sándor Farkasdi, Muhammad H. A. Saleh, Monica Lopez, Fernando Muñoz, Gabor Varga, Mauricio G. Araujo, Fabio Vignoletti   +7 more
wiley   +1 more source

Longitudinal patterns of fentanyl utilisation (medical versus illicit sources) in the United States 2015-2023: a retrospective cohort study. [PDF]

EClinicalMedicine
Lee S, Song W, Bates DW, Urman RD, Zhang P.   +4 more
europepmc   +1 more source

Analgesia postoperatoria con fentanyl transdérmico (25 μgr/hora vs. 50 μgr/hora) en pacientes sometidas a histerectomía abdominal

, 2014
El Fentanyl es un opioide sintético cuya administración transdérmica puede ser empleado para el control de dolor crónico y agudo. Objetivo: Comparar la administración de Fentanyl transdérmico 25 μgr/h Vs.
Rocha Terceros, Raquel Rocío, Torres Escalona, José Gregorio   +1 more
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