Results 11 to 20 of about 14,572 (209)

Greater locus coeruleus vulnerability in atypical clinicopathologic forms of Alzheimer's disease. [PDF]

Alzheimers Dement
Abstract INTRODUCTION The locus coeruleus (LC) degenerates early in Alzheimer's disease (AD). However, the extent of rostrocaudal degeneration across clinicopathologic heterogeneity remains underexplored in AD. METHODS Using digital pathology, we quantified LC neuronal density and area at three neuroanatomic levels in a large AD series.
Dunlop SR, Matchett BJ, Mannsbart AF, Al-Shaikh FSH, Peng Z, Rothberg DM, Tranovich JF, Duara R, Uribe IV, Gondrez J, Carter RE, Ferman TJ, Day GS, Graff-Radford NR, Dickson DW, Grinberg LT, Murray ME.   +16 more
europepmc   +2 more sources

Longitudinal 123I‐FP‐CIT SPECT Analysis Using DaTQUANT Software in Autopsy Confirmed Dementia with Lewy Bodies Patients [PDF]

Alzheimers Dement
Abstract Background Dementia with Lewy Bodies (DLB) has been overlooked or misdiagnosed as Alzheimer's disease (AD) dementia due to its frequent concomitant AD pathology with Lewy Body Disease (LBD) pathology. Although autopsy confirmation has been the gold standard for the precise diagnosis of DLB, time‐course 123I‐FP‐CIT SPECT (DaT‐SPECT) findings in
Miyagawa T, Przybelski S, Vernon C, Min H, Forsberg L, Fields J, McCarter S, Ferman T, Ramanan V, Graff‐Radford J, Jones D, Savica R, Reichard R, Parisi J, Nguyen A, Dickson D, Murray M, Day G, Graff‐Radford N, St. Louis E, Jain M, Kantarci K, Lowe V, Boeve B.   +23 more
europepmc   +4 more sources

Association between visual hallucinations and α-synuclein oligomers in patients with dementia with Lewy bodies. [PDF]

Alzheimers Dement
Abstract INTRODUCTION Visual hallucinations (VHs) represent one of the core clinical features of dementia with Lewy bodies (DLB); however, their underlying pathology remains unclear. METHODS We employed proximity ligation assay (PLA) and phosphorylated α‐synuclein (αSYN) immunohistochemistry to compare αSYN oligomers and Lewy‐related pathology across ...
Sekiya H, Franke L, Ono D, DeTure M, Ross OA, Day GS, Lachner C, Graff-Radford NR, McLean PJ, Ferman TJ, Dickson DW.   +10 more
europepmc   +2 more sources

Association between Human Leukocyte Antigen Alleles and Neuropathological Outcomes in Lewy Body Disease. [PDF]

Ann Neurol
Objective Lewy body disease (LBD) is a complex neurodegenerative disorder characterized by the accumulation of misfolded α‐synuclein in the brain. Neuroinflammation has long been implicated in LBD pathogenesis, and recent genetic studies in Parkinson's disease (a clinical manifestation of LBD) have shown consistent association with the human leukocyte ...
Gavrielatos M, Heckman MG, Soto-Beasley AI, Blumenfeld SG, Hou X, Koga S, Murray ME, Kasanuki K, Ono D, Fiesel FC, Uitti RJ, Fields JA, Botha H, Ramanan VK, Kantarci K, Lowe VJ, Jack CR, Ertekin-Taner N, Gibbs JR, Traynor BJ, Dalgard CL, Savica R, Graff-Radford J, Petersen RC, Reichard RR, Graff-Radford NR, Ferman TJ, Boeve BF, Wszolek ZK, Springer W, Gan-Or Z, Mignot E, Scholz SW, Dickson DW, Ross OA.   +34 more
europepmc   +2 more sources

Imperfect Synthetic Controls. [PDF]

J Appl Econ (Chichester Engl)
ABSTRACT The synthetic control method assumes the existence of a perfect synthetic control, which cannot exist if the outcomes are functions of transitory shocks with nonzero asymptotic variance and may not exist even in expectation for the treated unit. This paper first shows the benefits of estimating synthetic controls for all units.
Powell D.
europepmc   +2 more sources

NODDI reveals white matter microstructural changes in isolated REM sleep behavior disorder [PDF]

Alzheimers Dement
Abstract Background Isolated REM sleep behavior disorder (iRBD) is a parasomnia that reflects an evolving α‐synucleinopathy disorder, providing an opportunity to study early pathological changes. While diffusion tensor imaging (DTI) studies have shown white matter changes in iRBD, Neurite Orientation Dispersion and Density Imaging (NODDI) may offer ...
Mak E, Przybelski S, Reid R, Fought A, Schwarz C, Vemuri P, Jack C, Nie Y, De La Cruz H, Avidan A, Bliwise D, Campbell M, Criswell S, Davis A, Duff K, Martens K, Elliot J, Ferman T, Fields J, Forsberg L, Gagnon J, Gan‐Or Z, Howell M, Hu M, Hu X, Huddleston D, Kotzbauer P, Langley J, Lim M, Locke J, Lowe V, McCarter S, McLeland J, Miglis M, Mignot E, Miyagawa T, Neilson L, Nichols K, Pelletier A, Ross O, Schenck C, Wolfgang S, St. Louis E, Trotti L, Videnovic A, Xiong C, Postuma R, Ju Y, Boeve B, Kantarci K.   +49 more
europepmc   +2 more sources

Substantia Nigra Iron Deposition in Lewy Body Disease: A Magnetic Resonance Imaging and Neuropathology Study. [PDF]

Mov Disord
Abstract Objective To compare iron deposition in the substantia nigra (SN) as measured with quantitative susceptibility mapping (QSM) on antemortem magnetic resonance imaging (MRI) between individuals with and without Lewy‐related pathology at autopsy. Methods We performed a retrospective cohort study including 54 participants who underwent autopsy and
Diaz-Galvan P, Przybelski SA, Lesnick TG, Murray ME, Nguyen A, Reichard RR, Dickson DW, Ono D, Senjem ML, Schwarz CG, Gunter J, Lowe V, Forsberg LK, Fields JA, Savica R, Graff-Radford J, Ramanan VK, Jones D, Botha H, St Louis EK, Knopman D, Day GS, Graff-Radford N, Kremers W, Petersen RC, Jack CR, Ferman TJ, Boeve BF, Kantarci K.   +28 more
europepmc   +2 more sources

Whole-brain patterns of 1H-magnetic resonance spectroscopy imaging in Alzheimer's disease and dementia with Lewy bodies [PDF]

, 2016
Acknowledgements We thank Craig Lambert for his help in processing the MRS data. The study was funded by the Sir Jules Thorn Charitable Trust (grant ref: 05/JTA) and was supported by the National Institute for Health Research (NIHR) Newcastle Biomedical ...
Blamire, A. M., Hayes, L., He, J., O'Brien, J. T., Su, L., Watson, R.   +5 more
core   +2 more sources

MAGNA CARTA (BÜYÜK FERMAN) BİR MAGNA SANCTA (BÜYÜK KUTSAL) MI

Journal of International Social Research, 2018
exaly   +3 more sources

Human Rights Revisionism and the Canadian Parliamentary Coalition to Combat Antisemitism [PDF]

, 2011
This article focuses on the Canadian Parliamentary Coalition to Combat Antisemitism (CPCCA): a self-appointed group of parliamentarians dedicated to extinguishing what it calls “the new antisemitism.” Working from a Gramscian perspective, we identify key
Cairns, James, Ferguson, Susan
core   +3 more sources