Results 211 to 220 of about 2,478,172 (300)

Identification, fermentation optimization, and biocontrol efficacy of actinomycete YG-5 for the prevention of Alternaria leaf spot disease in star anise. [PDF]

Sci Rep
Pan J, Geng X, Cai Y, Yu Y, Hou Y, Liu Y, Ya C, Liu Q.   +7 more
europepmc   +1 more source

Mitochondrial Protection and Neural Repair via ROS‐Responsive Biomimetic Nanoparticles in Intracerebral Hemorrhage

Advanced Science, EarlyView.
A ROS‐responsive biomimetic nanoparticle platform co‐delivers DIDS and Mdivi‐1 to protect mitochondria and promote neural repair after intracerebral hemorrhage. By targeting LPAR1/VDAC1‐related mitochondrial dysfunction, the nanotherapy reduces oxidative injury, neuronal apoptosis, and blood‐brain barrier disruption, improving neurological recovery and
Ling Gao, Li Peng, Xiaobin Zheng, Cong Tan, Chuang Wang, Qijiang Xiong, Weiming Chen, Zhao Yang   +7 more
wiley   +1 more source

Oral Astilbin Nanogels Modulate Senescence‐Associated CD4+ T Cells and Promote Treg Induction in Aged Mice with Colitis

Advanced Science, EarlyView.
Fluorinated β‐glucan/pectin nanogels enable colon‐targeted oral delivery of astilbin through gastrointestinal protection, β‐glucanase‐responsive release, mucus penetration, and prolonged retention. The released astilbin attenuates senescence‐associated features of CD4+ T cells and promotes Treg responses, while the nanogel matrix modulates the gut ...
Lei Zhao, Xinyun Zhang, Qian Ren, Xue Song, Meifang Zhao, Rongshen Wang, Haocheng Du, Yan Chen, Peigen Xu, Jiangyun Liu, Jian Zhang, Jingjing Ma   +11 more
wiley   +1 more source

Optimization of Trichoderma Fermentation Medium

IOP Conference Series: Materials Science and Engineering, 2019
Sui Ming, Yonglin Guan, Xia Wu, Yang Zhang, Junru Li, Jiachao Rong, Rongqing Zhou, Guoying Li   +7 more
openaire   +1 more source

Rational construction of a high-quality and high-efficiency biosynthetic system and fermentation optimization for A82846B based on combinatorial strategies in Amycolatopsis orientalis. [PDF]

Microb Cell Fact
Zhao X, Zhu C, Gao W, Xie H, Lyu Z, Zhao Q, Li Y.   +6 more
europepmc   +1 more source

3D Bioprinted Blood–Brain–Tumor Barrier Spheroid‐Based In Situ Evaluation of Anticancer Compounds Against Glioblastoma: ROS‐Producing Ruthenium as a Potential Therapeutic Candidate

Advanced Science, EarlyView.
The blood–brain–tumor barrier (BBTB) penetration by anticancer drugs and their effects on glioblastoma (GBM) is assessed using 3D bioprinted‐spheroids. Anticancer drug‐induced U‐87 MG cell death is quantified through in situ imaging of spheroids using a cancer cell death probe. The Ru compound, a partial P‐gp substrate, induces greater tumor‐cell death
Hyunjung Lee, Chan Ho Jeon, Doyun Kim, Minjae Lee, Minji Kwon, Joon Myong Song   +5 more
wiley   +1 more source

Structural Variants in the Human Genome Associated With Gut Microbiome and Blood Metabolic Traits With Potential Causal Links

Advanced Science, EarlyView.
Based on a multi‐omics cohort of 2002 individuals comprising high‐depth whole‐genome and metagenomic sequencing data, blood metabolites, and detailed questionnaires, we identified 138 859 high‐confidence SVs, uncovering 36 significant SV–microbiome associations and 48 SV–blood metabolite associations.
Qun Zhou, Keqing Wang, Junhong Chen, Haoyu Wang, Xinjiang Tan, Xuanlin Huang, Zhiyin Lin, Xun Xu, Xin Jin, Shaoqiao Zhang, Liang Xiao, Yuanqiang Zou, Tao Zhang, Xiaomin Liu   +13 more
wiley   +1 more source

Meningeal Lymphatic LTBR Deficiency Links Spinal Cord Injury to Secondary Brain Pathology

Advanced Science, EarlyView.
Spinal cord injury (SCI) induces remote brain alterations beyond the injured spinal cord. This study links dysfunction of meningeal lymphatic vessels (mLVs) to neuroinflammation and neuronal injury after SCI. LTBR‐mediated lymphatic restoration improves meningeal lymphatic integrity and neurological outcomes, highlighting LTBR as a potential regulator ...
Yi Chen, Yu Tang, Chengpeng Hu, Xiaoyan Duan, LingXia Min, Boya Cong, Chao Ma, Mingliang Tan, Ya Luo, Pengfei Wei, Minpeng Xu, Zhou Feng, Jingming Hou   +12 more
wiley   +1 more source

Ionically Counter‐Programmable Phase‐Separation of Superstable Star‐Biopolyamide Coacervates for Electrothermally‐Responsive Pseudosolid Smart Windows

Advanced Science, EarlyView.
We develop bio‐based, star‐branched polyamides from itaconic acid and cadaverine with tunable lower critical solution temperature (LCST) transitions for dynamic solar modulation. Specific metal ion coordination with pyrrolidone moieties drives precise phase transitions via calcium‐induced salting‐in and sodium‐induced salting‐out mechanisms. Formulated
Jie Liu, Xiaotian Zhu, Jinjian Hou, Jinze Du, Mohammad Asif Ali, Maiko K. Okajima, Tatsuo Kaneko   +6 more
wiley   +1 more source

A Dual‐Delivery System Designed to Overcome EV‐Mediated Ferroptosis Resistance for Efficient Solid Tumor Therapy

Advanced Science, EarlyView.
(A) Establishment and characterization of the osteosarcoma‐targeted dual‐delivery nanoplatform mBAP1/siENO1@LNP‐OTP for simultaneous regulation of BAP1 and ENO1 in tumor cells. (B) After intravenous administration, mBAP1/siENO1@LNP‐OTP preferentially accumulates at tumor sites through OTP‐mediated targeting.
Yechao Shen, Zhenguo Cao, Zenan Wang, Liang Chen, Jiahao Zhang, Linjie Zeng, Boren Tan, Hengyuan Li, Jiashan Lai, Jiangchu Lei, Fanglu Chen, Peng Lin, Zhenxuan Shao, Zhan Wang   +13 more
wiley   +1 more source