Results 41 to 50 of about 18,300 (189)

Oseltamivir Population Pharmacokinetics in the Ferret: Model Application for Pharmacokinetic/Pharmacodynamic Study Design.

open access: yesPLoS ONE, 2015
The ferret is a suitable small animal model for preclinical evaluation of efficacy of antiviral drugs against various influenza strains, including highly pathogenic H5N1 viruses.
Micaela B Reddy   +8 more
doaj   +1 more source

Establishment of Humanized EFNB2/B3 Murine Models for Investigating Nipah Virus Pathogenesis

open access: yesAnimal Research and One Health, EarlyView.
ABSTRACT Nipah virus (NiV) is a zoonotic paramyxovirus classified as a WHO priority pathogen, which causes severe respiratory disease and encephalitis in humans with high mortality. Currently, no licensed vaccines or specific antiviral therapies are available.
Wei Dong   +6 more
wiley   +1 more source

Chronic atrophic endometritis and pyometra in a ferret: A case report

open access: yesAsian Pacific Journal of Reproduction, 2019
The aim of this report was to describe a clinical case of chronic atrophic endometritis as a complication of cystic endometrial hyperplasia-pyometra complex in a non-spayed ferret.
Anton Lazarinov Antonov   +2 more
doaj   +1 more source

Humans are not unique: difficult birth is common in placental mammals

open access: yesBiological Reviews, EarlyView.
ABSTRACT Human childbirth is widely presumed to be uniquely difficult and dangerous compared to birth in other mammals. Tight fetopelvic proportions can result in obstructed labour and contribute to high rates of maternal and neonatal mortality. Ideas summarised under the ‘obstetrical dilemma’ have contributed to this assumption by explaining difficult
Nicole D. S. Grunstra
wiley   +1 more source

Interspecies Transmission of Swine Influenza A Viruses and Human Seasonal Vaccine-Mediated Protection Investigated in Ferret Model

open access: yesEmerging Infectious Diseases, 2023
We investigated the infection dynamics of 2 influenza A(H1N1) virus isolates from the swine 1A.3.3.2 (pandemic 2009) and 1C (Eurasian, avian-like) lineages. The 1C-lineage virus, A/Pavia/65/2016, although phylogenetically related to swine-origin viruses,
Pauline M. van Diemen   +10 more
doaj   +1 more source

Functional validation of driver mutation‐specific uveal melanoma biomarkers: role of COL9A3 in cancer cell plasticity

open access: yesThe Journal of Pathology, EarlyView.
Abstract Uveal melanoma (UM) is a deadly ocular malignancy with well‐described genetic alterations that predict disease outcome. However, our current understanding of the biological underpinnings of high‐risk uveal melanoma progression remains relatively limited. Using RNA expression profiles from 250 patients with UM, we identified 12 novel biomarkers
QCC van den Bosch   +7 more
wiley   +1 more source

Genetic Characterization of Coronaviruses from Domestic Ferrets, Japan

open access: yesEmerging Infectious Diseases, 2014
We detected ferret coronaviruses in 44 (55.7%) of 79 pet ferrets tested in Japan and classified the viruses into 2 genotypes on the basis of genotype-specific PCR. Our results show that 2 ferret coronaviruses that cause feline infectious peritonitis–like
Yutaka Terada   +7 more
doaj   +1 more source

Public Willingness to Pay for Regenerative Agriculture: Socioeconomic Drivers and Perception of Ecosystem Services

open access: yesSustainable Development, EarlyView.
ABSTRACT Agricultural intensification is a key driver of soil erosion, biodiversity loss, and the progressive degradation of ecosystems, increasing the urgency for transformative agricultural models. Regenerative agriculture (RA) has emerged as a promising solution by integrating ecological principles with long‐term economic viability to restore ...
Beatriz Salazar‐Gálvez   +3 more
wiley   +1 more source

A Novel Bioreactor for Reconstitution of the Epithelium and Submucosal Glands in Decellularized Ferret Tracheas

open access: yesCells, 2022
Tracheal grafts introduce the possibility to treat airway pathologies that require resection. While there has been success with engraftment of the surface airway epithelium (SAE) onto decellularized tracheas, there has been minimal advancement in ...
Albert C. Pai   +5 more
doaj   +1 more source

The consequences of host heterogeneity for parasite transmission depend on how host infectiousness is determined

open access: yesJournal of Animal Ecology, EarlyView.
This study proposes two contrasting scenarios for how host infectiousness is determined: recipient dependence and donor dependence. These scenarios fundamentally alter how host heterogeneity shapes parasite transmission, demonstrating that the process by which infectiousness is determined is crucial for understanding the consequences of host ...
Jacob A. Cohen   +3 more
wiley   +1 more source

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