Results 101 to 110 of about 168,132 (304)

Quantification of neurodegeneration by measurement of brain-specific proteins [PDF]

, 2003
Quantification of neurodegeneration in animal models is typically assessed by time-consuming and observer-dependent immunocytochemistry. This study aimed to investigate if newly developed ELISA techniques could provide an observer-independent, cost ...
Baker, D., Petzold, A., Pryce, G., Thompson, E.J., Keir, G., Giovannoni, G.   +5 more
core  

PIAS3 CircRNA‐Loaded Lipid Nanoparticles Restore ALOX15 SUMOylation to Suppress Cementoblast Ferroptosis and Attenuate Orthodontically Induced Root Resorption

Advanced Science, EarlyView.
Orthodontic compression suppresses PIAS3 expression in cementoblasts, impairing ALOX15 SUMOylation and ubiquitin‐mediated degradation, which leads to ALOX15 accumulation, lipid peroxidation, ferroptosis, and osteoclastogenesis. Local delivery of PIAS3 circRNA‐loaded lipid nanoparticles restores the PIAS3–ALOX15 regulatory pathway, alleviates ...
Yifei Hou, Chongzheng Yan, Xinrui Xu, Zihan Yang, Xinhui Wu, Hongxu Zhao, Xuan Song, Jianing Zhang, Yijing Li, Aohua Yang, Xiamei Lu, Yi Liu   +11 more
wiley   +1 more source

Heavy metal detoxification by recombinant ferritin from Apostichopus japonicus

, 2017
Ferritin fromApostichopus japonicasshowed better ability in heavy metal detoxification than horse spleen ferritin.
Kaixue Si, Yanyan Li, Ling-Zhi Cheong, Jun Zhou, Tinghong Ming, Ye Li, Liping Chen, Chenyang Lu, Xiaoting Qiu, Xiurong Su   +9 more
core   +1 more source

A Robust Deep Temporal Causal Discovery Platform for Single‐Cell Gene Regulatory Network Reconstruction

Advanced Intelligent Discovery, EarlyView.
scTIGER2.0 is a deep‐learning framework that infers gene regulatory networks from single‐cell RNA sequencing data. By integrating correlation, pseudotime ordering, deep learning and bootstrap‐based significance testing, it reduces false positives and reveals directional gene interactions.
Nishi Gupta, Madison Dautle, Shaoqiang Zhang, Yong Chen   +3 more
wiley   +1 more source

Latent Iron Deficiency and Iron Deficiency Anaemia in Hypoferritinemic Patients

Journal of Rawalpindi Medical College, 2014
Background : To find out the frequency of iron deficiency anaemia (IDA) and latent iron deficiency (LID) amongst hypoferritinemic individuals Methods : In this descriptive study individuals (n=1821) who were referred for serum ferritin estimation, for a ...
Masooma Raza
doaj  

Targeting macrophage ferritin heavy chain mitigates ferroptosis and lung injury in experimental acute respiratory distress syndrome

Nature Communications
Ferritin, composed of heavy chain (FTH1) and light chain (FTL) subunits, is a key intracellular iron storage protein, but the origin and biological role of extracellular ferritin (ex-ferritin) remain poorly understood.
William Z. Zhang, Kihwan Kim, Divya Bhatia, Lynne Faherty, Will Simmons, Eleni Kallinos, Sebastian E. Carrasco, Katherine L. Hoffman, Sean Houghton, Chia-Lang Hsu, Leora Haber, Cem Meydan, Christopher E. Mason, Ananda S. Mirchandani, Sarah R. Walmsley, Parag Goyal, Kuei-Pin Chung, Karla V. Ballman, David Redmond, Joseph D. Mancias, Augustine M. K. Choi, Edward J. Schenck, Maria Plataki, Suzanne M. Cloonan   +23 more
doaj   +1 more source

Haptoglobin genotypes, inflammation status and their associations with hemoglobin levels in stage 4 chronic kidney disease patients with anemia [PDF]

Background and aims: Anemia and increased inflammation are the main causes of mortality in chronic kidney disease (CKD) patients. This study was designed to explore the probable relationship of hemoglobin (Hb) with serum haptoglobin (HP), its ...
ارگانی, حسن, حسینی اصل, سید سعید, علی پناه مقدم, رضا, قربانی حق جو, امیر   +3 more
core  

The Presence and Percentage of Circulating Nucleated Red Blood Cells Reveal Distinct Characteristics in Adults With Sickle Cell Disease

American Journal of Hematology, EarlyView.
ABSTRACT Although circulating nucleated red blood cells (cNRBCs) have previously been detected in patients with sickle cell disease (SCD), their prevalence and clinical significance during steady‐state disease have not been established. We retrospectively analyzed 270 adults with an SS or Sβ0‐thalassemia genotype.
Ugo Boccadifuoco, Ivan Lerner, Auria Godard, Luc Darnige, Laure Joseph, Wassim El Nemer, Geoffrey Cheminet, Jean‐Benoit Arlet   +7 more
wiley   +1 more source

The kinetics of haemoglobin and ferritin in longitudinal community patients with iron deficiency or hypoxia

, 2017
Background: Red cell distribution width (RDW) is well recognised as a marker of iron-deficient anaemia, as well as useful to the distinction between some anaemic states.
Richardson, Alice M, Lidbury, Brett A, Badrick, Tony, Arnott, Ashley   +3 more
core   +1 more source

Animal models of anemia of inflammation: Methodological advances, limitations, and translational applications

Animal Models and Experimental Medicine, EarlyView.
Anemia of inflammation is a highly prevalent secondary anemia complicating chronic inflammatory diseases. Current animal models are categorized into sterile inflammation, disease‐specific, and genetically engineered models, with comparative analysis of their modeling principles, characteristic phenotypes, and translational advantages to elucidate core ...
Jiayi Cheng, Xiaodi Zhou, Qian Liu, Zixian Liu, Hao Wu   +4 more
wiley   +1 more source