Results 81 to 90 of about 194,437 (305)

Impact of Inflammation on Ferritin, Hepcidin and the Management of Iron Deficiency Anemia in Chronic Kidney Disease

Nutrients, 2018
Iron deficiency anemia (IDA) is a major problem in chronic kidney disease (CKD), causing increased mortality. Ferritin stores iron, representing iron status. Hepcidin binds to ferroportin, thereby inhibiting iron absorption/efflux.
N. Ueda, K. Takasawa
semanticscholar   +1 more source

Ferritinophagy Rewires Carnitine‐Dependent Lipid Metabolism to Inhibit PRRSV and IAV Replication

Advanced Science, EarlyView.
NCOA4‐mediated ferritinophagy reprograms carnitine metabolism by disrupting Fe‐S cluster biogenesis, thereby establishing an iron‐lipid axis that suppresses various viruses, including PRRSV and IAV. However, viruses counteract this mechanism by degrading NCOA4.
Kaifeng Guan, Chenyang Yuan, Zekun Meng, Yanan Wang, Xueying Zhai, Chunjie Huang, Xiang Zhou, Gaiping Zhang   +7 more
wiley   +1 more source

Association of Serum Ferritin Levels with Haematological Parameters in Thalassaemia Major Patients

Journal of Rawalpindi Medical College, 2014
Background: To study the association of serum ferritin levels with haematological parameters in thalassaemia major patients. Methods: A total of 135 patients of thalassemia major were selected for this descriptive, cross sectional study.
Amna Faruqi
doaj  

MiR‐940 Suppresses Ferroptosis by Controlling Expression of Key Regulatory Genes

Advanced Science, EarlyView.
A CRISPR‐based screening identified miR‐940 as a critical suppressor of ferroptosis in cancer. By coordinating the downregulation of pro‐ferroptotic genes with the upregulation of GPX4, miR‐940 establishes a regulatory network that protects against ferroptosis and correlates with poor clinical outcomes in distinct cancer entities.
Andrea Kolak, Juliane Tschuck, Stefanie A. I. Weiß, Daniel Kaemena, Karolin Klimm, Ana Galhoz, Larissa Ringelstetter, Myles Fennell, Juliane Merl‐Pham, Anna Artati, Stefanie Strasser, Ralph Garippa, Michael Witting, Hans Zischka, Joel A. Schick, Stefanie M. Hauck, Michael P. Menden, Michelle Vincendeau, Brent R. Stockwell, Kamyar Hadian   +19 more
wiley   +1 more source

Extracellular vesicles-derived ferritin from lipid-induced hepatocytes regulates activation of hepatic stellate cells

Heliyon
Introduction: and objectives: Extracellular vesicles (EVs) have emerged as key players in intercellular communication within the context of non-alcoholic fatty liver disease (NAFLD).
Mengxue Sun, Min Tang, Yiting Qian, Guannan Zong, Gaowang Zhu, Yan Jiang, Yingjie Mu, Minjun Zhou, Qin Ding, Hao Wang, Fengshang Zhu, Changqing Yang   +11 more
doaj   +1 more source

Correlation of serum ferritin levels, in female patients with chronic diffuse hair loss: A cross sectional study

Indian Journal of Health Sciences and Biomedical Research KLEU, 2017
Context: Iron is involved in critical physiological processes within the hair follicle, suggesting that iron deficiency (ID) could disrupt hair synthesis.
Sridevi Ramachandra Raichur, A M Pandit, Anil Malleshappa   +2 more
doaj   +1 more source

Ferritin Light Chain Confers Protection Against Sepsis-Induced Inflammation and Organ Injury

Frontiers in Immunology, 2019
Despite the prevalence and recognition of its detrimental impact, clinical complications of sepsis remain a major challenge. Here, we investigated the effects of myeloid ferritin heavy chain (FtH) in regulating the pathogenic sequelae of sepsis.
Abolfazl Zarjou, Laurence M. Black, Kayla R. Mccullough, T. Hull, S. Esman, Ravindra Boddu, S. Varambally, D. Chandrashekar, W. Feng, P. Arosio, Maura Poli, J. Balla, Subhashini Bolisetty   +12 more
semanticscholar   +1 more source

A Brain‐Penetrant Nanobody Reveals GSK3β‐Driven Proline‐Directed Phosphorylation as a Master Regulator of Ischemic Neurodegeneration

Advanced Science, EarlyView.
A brain‐targeted nanoparticle enables delivery of a therapeutic nanobody (Nb.29E9) that inhibits pathogenic GSK3β signaling. This intervention restores AMPK/mTORC1/TGFβ homeostasis, attenuates neuroinflammation and oxidative stress, and promotes long‐term functional recovery after ischemic stroke.
Lan Li, Muyang Li, Lei Sun, Ying Yang, Yuanshun Wu, Ziyi Yin, Anni Wang, Peiyang Zhou, Shaoxiang Luo, Jian Chen, Jun Qin, Zhibing Ai, Zilong Yuan, Zhiqiang Dong, Min Zhang   +14 more
wiley   +1 more source

Inflammation is not the cause of an elevated serum ferritin in non-alcoholic fatty liver disease

Annals of Hepatology, 2014
Background. In non-alcoholic fatty liver disease (NALFD), it has often been assumed that an elevation in serum ferritin is likely related to inflammation rather than iron overload.Material and methods.
Melanie D. Beaton, Subrata Chakrabarti, Paul C. Adams   +2 more
doaj   +1 more source

Iron Supply via NCOA4-Mediated Ferritin Degradation Maintains Mitochondrial Functions

Molecular and Cellular Biology, 2019
Iron is an essential nutrient for mitochondrial metabolic processes, including mitochondrial respiration. Ferritin complexes store excess iron and protect cells from iron toxicity.
M. Fujimaki, Norihiko Furuya, S. Saiki, T. Amo, Yoko Imamichi, N. Hattori   +5 more
semanticscholar   +1 more source