Results 71 to 80 of about 123,800 (265)

Ferritin Degradation by Pneumococcal HtrA, RadA and ClpP Serine Proteases : A Probable Way For Releasing and Acquisition Of Iron

Infection and Drug Resistance, 2020
Mozhgan Kheirandish,1 Behrooz Motlagh,2 Davoud Afshar1 1Department of Microbiology and Virology, School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran; 2Department of Clinical Biochemistry, School of Medicine, Zanjan University of ...
Kheirandish M, Motlagh B, Afshar D
doaj  

Single‐cell atlas of neuroglial dynamics in SNCA‐A53T Parkinson's disease mouse model

Animal Models and Experimental Medicine, EarlyView.
We performed single‐cell RNA sequencing of midbrain and striatal tissues from SNCA‐A53T Parkinson's disease (PD) mice, revealing glia‐enriched PD‐risk gene signatures and disease‐specific subpopulations. Transcriptional dysregulation of key TFs (e.g., Rorb, Foxc1) and enhanced neuroinflammatory signaling (SEMA, CCL, MIF) were identified.
Binqing Qin, Zichu Fu, Xuanxuan Zou, Senmao Chai, Jingjing Weng, Puqing Wang, Xiaodong Sun, Ming Sang   +7 more
wiley   +1 more source

Design and Application of Nanozymes: Current Trends and Cutting‐Edge Breakthroughs

Advanced Science, EarlyView.
Kelong Fan, Hui Wei, Xiyun Yan
wiley   +1 more source

Sappanwood extract modulates hepatic structure–function in hepatomegaly and hepcidin related iron regulatory pathways in a phenylhydrazine induced hemolytic anemia rat model relevant to thalassemia

Animal Models and Experimental Medicine, EarlyView.
Phenylhydrazine (PHZ) induces hemolytic anemia characterized by increased erythrocyte destruction and ineffective erythropoiesis, leading to hepcidin suppression through disruption of the BMP/SMAD signaling pathway. Reduced hepcidin levels enhance intestinal iron absorption and hepatic iron accumulation, leading to hepatic iron overload.
Mohammad Indra Pratama, Ratu Safitri, Desak Made Malini, Mas Rizky A. A. Syamsunarno, Mohammad Ghozali, Madihah Madihah   +5 more
wiley   +1 more source

Assessing Serum Iron and Ferritin Levels in Relation to Smoking Status among Jordanian Adults

Journal of Health Research
Background: Balanced iron and ferritin levels are essential for many biological functions; unfortunately, smoking may disrupt these levels. The objective of this study was to investigate the association between smoking status with serum iron/ferritin ...
Lara M. Al-Natour, Ahmed Salem, Fanar Alsmarat, Lina Al-Zerikat, Tasneem Al-Awaida, Layth Al-Ramahi, Yousef Shawawrah, Mariam Al-Husari   +7 more
doaj   +1 more source

Safety and Feasibility of Magnetic Separation‐Based Blood Purification

Advanced NanoBiomed Research, EarlyView.
We present the preclinical biological safety and translational feasibility of a magnetic nanoparticle‐based extracorporeal blood purification platform for removal of disease‐causing blood factors. ISO 10993‐compliant studies and exaggerated worst‐case exposure models demonstrate efficient nanoparticle extraction (≥99.9%), favorable biocompatibility ...
Carlos A. Mora, Laurine Rijsbergen, Jan Waskowski, Gaelle Clermont, Florian Dingreville, Chandrashekara Vishwanath, Rajesh Karunanithi, Alexander Gogos, Jean‐Claude Metzger, Manuel Baumgartner, Joerg C. Schefold, Inge K. Herrmann   +11 more
wiley   +1 more source

Prognostic implications of serum ferritin levels in non-anemic women with stage 3 chronic kidney disease

Frontiers in Nutrition
IntroductionChronic kidney disease (CKD) is often accompanied by iron deficiency and persistent inflammation, both of which complicate the evaluation of iron metabolism and its clinical relevance.
Min-Tser Liao, Min-Tser Liao, Chien-Lin Lu, Chien-Lin Lu, Yi-Chou Hou, Yi-Chou Hou, Joshua Wang, Kuo-Wang Tsai, Li-Jane Shih, Li-Jane Shih, Chia-Chao Wu, Yi-Chun Wang, Yi-Chun Wang, Kuo-Cheng Lu, Kuo-Cheng Lu   +14 more
doaj   +1 more source

Ursolic Acid Alleviates Orchitis via Modulating Ferroptosis in Peritubular Myoid Cells of Testis

Animal Research and One Health, EarlyView.
Ursolic acid modulates key ferroptosis‐related pathways in the peritubular myoid cells of the testis in forest musk deer. ABSTRACT Chronic stress adversely affects reproductive health, increasing susceptibility to pathologies such as orchitis. Additionally, the maintenance of iron homeostasis is essential for preserving the function of the testicles ...
Yang Wang, Tianqi Jin, Zexin Chen, Ye Gong, Qimin Liu, Zifang Wu, Heran Cao, Yan Li, Yuyan Liu, Tianhao Yang, Zhihong Jiang, Wuzi Dong   +11 more
wiley   +1 more source

Latent Iron Deficiency and Iron Deficiency Anaemia in Hypoferritinemic Patients

Journal of Rawalpindi Medical College, 2014
Background : To find out the frequency of iron deficiency anaemia (IDA) and latent iron deficiency (LID) amongst hypoferritinemic individuals Methods : In this descriptive study individuals (n=1821) who were referred for serum ferritin estimation, for a ...
Masooma Raza
doaj  

A Multifaceted Interplay Among Hemophagocytosis, Interleukin‐18, and Type I Interferon Distinguishes Still Disease From Other Autoinflammatory Diseases

Arthritis &Rheumatology, EarlyView.
Objective The unknown pathophysiology and the lack of specific features for systemic juvenile idiopathic arthritis and adult‐onset Still disease (collectively known as Still disease; SD) delay diagnosis and appropriate treatment. The goal of this study was to identify features and mechanisms that distinguish SD from other systemic autoinflammatory ...
Yvonne M. Mueller, Charlotte Girard, Harmen J. G. van de Werken, Stefan J. Erkeland, Dwin G. B. Grashof, Laurie Vaillant, Renske J. H. den Dekker, Iris van Zuijen, Sharon Veenbergen, Fanny Coffin, Eric Bindels, Yvan Jamilloux, Katerina Laskari, Vassili Soumelis, Bruno Fautrel, Cem Gabay, Peter D. Katsikis   +16 more
wiley   +1 more source